Search results for "Multivariate Analysis"

showing 10 items of 1076 documents

THE PURPOSING OF NEW COMPOUNDS OR THE RE-PURPOSING OF OLD DRUGS BY MEANS OF MULTIVARIATE ANATYSIS ON MOLECULAR DESCRIPTORS

2010

RE-PURPOSINGMULTIVARIATE ANALYSISMOLECULAR DESCRIPTORS
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An Open-Label Trial of 12-Week Simeprevir plus Peginterferon/Ribavirin (PR) in Treatment-Naïve Patients with Hepatitis C Virus (HCV) Genotype 1 (GT1)

2016

Background: Shortening duration of peginterferon-based HCV treatment reduces associated burden for patients. Primary objectives of this study were to assess the efficacy against the minimally acceptable response rate 12 weeks post-treatment (SVR12) and safety of simeprevir plus PR in treatment-naïve HCV GT1 patients treated for 12 weeks. Additional objectives included the investigation of potential associations of rapid viral response and baseline factors with SVR12. Methods: In this Phase III, open-label study in treatment-naïve HCV GT1 patients with F0-F2 fibrosis, patients with HCV-RNA 12-week regimen. Conclusions: Overall SVR12 rate (66%) was below the target of 80%, indicating that sho…

RNA virusesMale0301 basic medicineSimeprevirDecision AnalysisPsychologie appliquéelcsh:MedicineHepacivirusmedicine.disease_causeTherapy naivechemistry.chemical_compoundMathematical and Statistical Techniques0302 clinical medicineRecurrenceSimeprevirlcsh:SciencePathology and laboratory medicineMultidisciplinaryHepatitis C virusPharmaceuticsHepatitis CMedical microbiologyViral LoadMiddle AgedSciences bio-médicales et agricolesPEGINTERFERON/RIBAVIRINHepatitis C3. Good healthTreatment OutcomeResearch DesignVirusesPhysical SciencesRegression AnalysisEngineering and TechnologyFemale030211 gastroenterology & hepatologyPathogensManagement EngineeringBiologieViral loadStatistics (Mathematics)HumanResearch ArticleAdultmedicine.medical_specialtyGenotypeClinical Research DesignHepatitis C virusResearch and Analysis MethodsMicrobiologyAntiviral AgentsYoung Adult03 medical and health sciencesDrug TherapyVirologyRibavirinmedicineHumansddc:610Statistical MethodsAgedAntiviral AgentMedicine and health sciencesHepaciviruFlavivirusesbusiness.industryRibavirinDecision Treeslcsh:ROrganismsViral pathogensBiology and Life Sciencesmedicine.diseaseFibrosisVirologyHepatitis virusesMicrobial pathogensClinical trial030104 developmental biologychemistryFamily medicineMultivariate Analysislcsh:QAdverse EventsbusinessMathematicsViral Transmission and InfectionDevelopmental BiologyPLOS ONE
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The role of PNI to predict survival in advanced hepatocellular carcinoma treated with Sorafenib

2020

Background and aims The present study aims to investigate the role of the prognostic nutritional index (PNI) on survival in patients with advanced hepatocellular carcinoma (HCC) treated with sorafenib. Methods This multicentric study included a training cohort of 194 HCC patients and three external validation cohorts of 129, 76 and 265 HCC patients treated with Sorafenib, respectively. The PNI was calculated as follows: 10 × serum albumin (g/dL) + 0.005 × total lymphocyte count (per mm3). Univariate and multivariate analyses were performed to investigate the association between the covariates and the overall survival (OS). Results A PNI cut-off value of 31.3 was established using the ROC an…

RNA virusesMaleEtiologyCancer TreatmentHepacivirusKaplan-Meier EstimateBiochemistryCohort StudiesWhite Blood CellsMathematical and Statistical TechniquesRetrospective StudieAnimal CellsAdult; Aged; Aged 80 and over; Antineoplastic Agents; Carcinoma Hepatocellular; Cohort Studies; Female; Humans; Italy; Kaplan-Meier Estimate; Liver Neoplasms; Lymphocyte Count; Male; Middle Aged; Prognosis; Retrospective Studies; Serum Albumin; Sorafenib; Nutrition AssessmentMedicine and Health Sciences80 and overLymphocytesPathology and laboratory medicineAged 80 and overHepatitis C virusLiver DiseasesStatisticsQLiver NeoplasmsRMedical microbiologyMiddle AgedSorafenibPrognosisOncologyItalyLiver NeoplasmPhysical SciencesVirusesMedicineFemalePathogensCellular TypesHumanResearch ArticleAdultHepatitis B virusCarcinoma HepatocellularImmune CellsScienceImmunologyAntineoplastic AgentsGastroenterology and HepatologySerum Albumin ...Research and Analysis MethodsCarcinomasMicrobiologyAlbuminsGastrointestinal TumorsHumansLymphocyte CountStatistical MethodsSerum AlbuminAgedRetrospective StudiesBlood CellsAdult Aged 80 and over Antineoplastic Agents Carcinoma Hepatocellular Cohort Studies Female Humans Italy Kaplan-Meier Estimate Liver Neoplasms Lymphocyte Count Male Middle Aged Prognosis Retrospective Studies Serum Albumin Sorafenib Nutrition AssessmentBiology and life sciencesFlavivirusesCarcinomaViral pathogensOrganismsCancers and NeoplasmsProteinsHepatocellularHepatocellular CarcinomaCell Biologyprognostic nutritional index (PNI) hepatocellular carcinoma (HCC) sorafenib. survival mRECISTHepatitis virusesMicrobial pathogensNutrition AssessmentMultivariate AnalysisCohort StudieMathematics
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Home-based HIV testing: Using different strategies among transgender women in Argentina.

2019

Background In Argentina, HIV prevalence among transgender women (TGW) has been reported at 34%. The stigma is one of the most important factors limiting their access to healthcare services. The aims of this study were to compare different HIV testing methodologies, to determine the factors associated with HIV diagnosis and to determine the feasibility of a home-based HIV testing service for TGW. Methods A multidisciplinary team performed home-based HIV testing interventions in four cities of Argentina. Participants self-identified as TGW, older than 14 years and with a negative or unknown HIV status. Blood samples were screened by two rapid tests (RT), one based on antibodies (Determine™ HI…

RNA virusesMultivariate analysisEpidemiologyPsychological interventionSocial SciencesHIV InfectionsLogistic regressionPathology and Laboratory MedicineTransgender womenGeographical locations0302 clinical medicineImmunodeficiency VirusesSociologyMedicine and Health Sciences030212 general & internal medicineYoung adultEnzyme-Linked Immunoassayseducation.field_of_studyMultidisciplinarySchoolsQRvirus diseasesHIV diagnosis and managementMedical MicrobiologyHIV epidemiologyViral PathogensVirusesMedicineInfectious diseasesFemalePathogens0305 other medical scienceViral loadResearch ArticleAdultmedicine.medical_specialtySciencePopulationArgentinaSexually Transmitted DiseasesHiv testingViral diseasesResearch and Analysis MethodsTransgender PersonsMicrobiologyEducation03 medical and health sciencesYoung AdultInternal medicineRetrovirusesmedicineHumanseducationImmunoassaysMicrobial Pathogens030505 public healthbusiness.industryLentivirusOrganismsBiology and Life SciencesHIVSouth AmericaDiagnostic medicineLogistic ModelsMultivariate AnalysisImmunologic TechniquesFeasibility StudiesReagent Kits DiagnosticPeople and placesbusinessPloS one
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Portal Vein Thrombosis Relevance on Liver Cirrhosis: Italian Venous Thrombotic Events Registry

2016

Portal vein thrombosis may occur in cirrhosis; nevertheless, its prevalence, and predictors are still elusive. To investigate this issue, the Italian Society of Internal Medicine undertook the “Portal vein thrombosis Relevance On Liver cirrhosis: Italian Venous thrombotic Events Registry” (PRO-LIVER). This prospective multicenter study includes consecutive cirrhotic patients undergoing Doppler ultrasound examination of the portal area to evaluate the prevalence and incidence of portal vein thrombosis over a 2-year scheduled follow-up. Seven hundred and fifty-three (68 % men; 64 ± 12 years) patients were included in the present analysis. Fifty percent of the cases were cirrhotic outpatients.…

RegistrieLiver CirrhosisMaleCirrhosisHepatocellular carcinoma030204 cardiovascular system & hematologyGastroenterology0302 clinical medicineEsophageal varicesPrevalenceMedicineProspective StudiesRegistriesProspective cohort studyMultivariate AnalysiVenous ThrombosisPortal VeinAnticoagulants; Esophageal varices; Hepatocellular carcinoma; Liver failure; Splanchnic venous thrombosis; Emergency Medicine; Internal MedicineMiddle AgedPortal vein thrombosisVenous thrombosisSplanchnic venous thrombosis Anticoagulants Liver failure Hepatocellular carcinoma Esophageal varicesSplanchnic venous thrombosisItalyLiverEmergency MedicineFemale030211 gastroenterology & hepatologymedicine.symptomSettore SECS-S/01 - StatisticaHumanmedicine.medical_specialtyLiver CirrhosiSocio-culturaleEsophageal varicesAsymptomatic03 medical and health sciencesAnticoagulants Esophageal varices Hepatocellular carcinoma Liver failure Splanchnic venous thrombosisInternal medicineInternal MedicineHumansAgedHepatologyEsophageal varicebusiness.industryAnticoagulantLiver failureAnticoagulants; Esophageal varices; Hepatocellular carcinoma; Liver failure; Splanchnic venous thrombosis;AnticoagulantsSplanchnic venous thrombosimedicine.diseaseSurgeryProspective StudieSplanchnic venous thrombosis Anticoagulants Liver failure Hepatocellular carcinoma Esophageal varicesMultivariate AnalysisUpper gastrointestinal bleedingComplicationbusinessJournal of Hepatology
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Antibiotic use and associated factors in a large sample of hospitalised older people

2019

Objectives: The aims of this study were to assess (i) the prevalence of antibiotic use, (ii) factors associated with their use and (iii) the association with in-hospital mortality in a large sample of hospitalised older people in Italy.Methods: Data were obtained from the 2010-2017 REPOSI register held in more than 100 internal medicine and geriatric wards in Italy. Patients aged >= 65 years with at least one antibiotic prescription during their hospitalisation were selected. Multivariable logistic regression models were used to determine factors associated with antibiotic use.Results: A total of 5442 older patients were included in the analysis, of whom 2786 (51.2%) were prescribed anti…

RegistrieMale0301 basic medicineAntibioticsLogistic regression0302 clinical medicineDrug Prescription80 and overPrevalenceImmunology and AllergyLS4_4Hospital MortalityRegistries030212 general & internal medicineMultivariate AnalysiRespiratory Tract InfectionsAged 80 and overAnti-Bacterial AgentsHospitalizationItalyAntibiotic useFemaleHumanMicrobiology (medical)medicine.medical_specialtyLogistic ModelInternal medicine wardmedicine.drug_class030106 microbiologyImmunologySocio-culturaleDrug PrescriptionsMicrobiologyOdds03 medical and health sciencesAntibiotic resistanceAnti-Bacterial AgentmedicineAntibiotic use; Internal medicine ward; Older people; Aged; Aged 80 and over; Anti-Bacterial Agents; Drug Prescriptions; Female; Geriatric Assessment; Hospital Mortality; Hospitalization; Humans; Italy; Logistic Models; Male; Multivariate Analysis; Prevalence; Registries; Respiratory Tract InfectionsHumansMedical prescriptionAntibiotic useGeriatric AssessmentAgedbusiness.industryConfidence intervalLogistic ModelsAntibiotic use Internal medicine ward Older peopleMultivariate AnalysisEmergency medicineOlder peopleOlder peoplebusinessAntibiotic use; Internal medicine ward; Older peopleJournal of Global Antimicrobial Resistance
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Mortality rate and risk factors for gastrointestinal bleeding in elderly patients

2019

Abstract Background Gastrointestinal bleeding (GIB) is burdened by high mortality rate that increases with aging. Elderly patients may be exposed to multiple risk factors for GIB. We aimed at defining the impact of GIB in elderly patients. Methods Since 2008, samples of elderly patients (age ≥ 65 years) with multimorbidity admitted to 101 internal medicine wards across Italy have been prospectively enrolled and followed-up (REPOSI registry). Diagnoses of GIB, length of stay (LOS), mortality rate, and possible risk factors, including drugs, index of comorbidity (Cumulative Illness Rating Scale [CIRS]), polypharmacy, and chronic diseases were assessed. Adjusted multivariate logistic regressio…

RegistrieMaleSettore MED/09 - Medicina Interna030204 cardiovascular system & hematologySeverity of Illness Index0302 clinical medicineRisk Factors80 and over030212 general & internal medicineHospital MortalityProspective StudiesRegistriesProspective cohort studyMultivariate AnalysiAged 80 and overDiverticulosisMortality rateDiverticulosiGastric ulcerAnemiaAnemia; Anticoagulant; Antiplatelet drug; Diverticulosis; Gastric ulcer; Multimorbidity; Internal MedicineItalyPlatelet aggregation inhibitorFemaleGastrointestinal HemorrhageAntiplatelet drugHumanGastrointestinal bleedingmedicine.medical_specialtyLogistic ModelAnemiaSocio-culturaleAnemia Anticoagulant Antiplatelet drug Diverticulosis Gastric ulcer Multimorbidity03 medical and health sciencesInternal medicineSeverity of illnessInternal MedicinemedicineHumansAnemia; Anticoagulant; Antiplatelet drug; Diverticulosis; Gastric ulcer; Multimorbidity; Aged; Aged 80 and over; Female; Gastrointestinal Hemorrhage; Hospital Mortality; Humans; Italy; Length of Stay; Logistic Models; Male; Multivariate Analysis; Platelet Aggregation Inhibitors; Prospective Studies; Registries; Risk Factors; Severity of Illness Index; MultimorbidityAgedPolypharmacybusiness.industryPlatelet Aggregation InhibitorRisk FactorAnemia; Anticoagulant; Antiplatelet drug; Diverticulosis; Gastric ulcer; MultimorbidityAnticoagulantMultimorbidityAnemia Anticoagulant Antiplatelet drug Diverticulosis Gastric ulcer Multimorbidity Aged Aged 80 and over Female Gastrointestinal Hemorrhage Hospital Mortality Humans Italy Length of Stay Logistic Models Male Multivariate Analysis Platelet Aggregation Inhibitors Prospective Studies Registries Risk Factors Severity of Illness Index MultimorbidityLength of Staymedicine.diseaseComorbidityProspective StudieLogistic ModelsMultivariate AnalysisbusinessPlatelet Aggregation Inhibitors
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Incidence and prognostic factors related to major adverse cerebrovascular events in patients with complex aortic diseases treated by the chimney tech…

2018

Abstract Objective Endovascular aneurysm repair (EVAR) with the chimney technique (ch-EVAR) has been used for the treatment of aortic aneurysms as an alternative approach to fenestrated endografting or open repair. Nonetheless, the need for an upper extremity arterial access may contribute to a higher risk for periprocedural cerebrovascular events. This study reports on the perioperative cerebral and major adverse cardiac and cerebrovascular events (MACCE) after ch-EVAR. Methods The PERICLES registry (PERformance of the chImney technique for the treatment of Complex aortic pathoLogiES) is an international, retrospective multicenter study evaluating the performance of ch-EVAR for the treatme…

RegistrieMaleTime Factorsmedicine.medical_treatment030204 cardiovascular system & hematologySettore MED/22 - Chirurgia VascolareEndovascular aneurysm repair0302 clinical medicineRetrospective StudieRisk FactorsCause of DeathCarotid artery diseaseOdds RatioRegistries030212 general & internal medicineMultivariate AnalysiStrokeCause of deathAged 80 and overIncidenceEndovascular ProceduresAtrial fibrillationchimney technique; stroke; aortic archMiddle AgedStrokeHeart DiseaseTreatment OutcomeIschemic Attack TransientCerebrovascular DisorderCardiologyFemaleCardiology and Cardiovascular MedicineHumanAdultmedicine.medical_specialtyAcute coronary syndromeLogistic ModelTime FactorHeart DiseasesOperative TimeAortic DiseasesBlood Vessel Prosthesis Implantation03 medical and health sciencesInternal medicinemedicineHumanscardiovascular diseasesAgedRetrospective StudiesEndovascular ProcedureChi-Square Distributionbusiness.industryRisk FactorOdds ratioPerioperativeAortic Diseasemedicine.diseaseSurgeryCerebrovascular DisordersLogistic ModelsMultivariate AnalysisSurgerybusiness
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Corporate Governance Effects on Firm Performance: a Literature Review

2021

The objective of this paper is to analyze the results of recent empirical research concerning the impact of corporate governance on firm performance and reflect potential research design problems which lead to inconsistent results. By means of a literature review including all articles of academic journal data bases with a journal quality rating of at least a C-rating in the VHB Journal Rating or above ‘3’ in the ABS Academic Journal Rating, respectively, the recent empirical research articles are analyzed regarding their main results. Two main groups of studies are identified: studies on company level to determine the impact of single corporate governance variables such as board size, chai…

Research designMultivariate analysisbusiness.industryCorporate governance05 social sciencesAccountingEmpirical researchQuality ratingMultiple time dimensions0502 economics and businessEconomicsGeneral Earth and Planetary Sciences050207 economicsbusiness050203 business & managementGeneral Environmental ScienceRegional Formation and Development Studies
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Characterization of the alcoholic fraction of vegetable oils by derivatization with diphenic anhydride followed by high-performance liquid chromatogr…

2008

Abstract Aliphatic and triterpene alcohols present in vegetable oils have been identified and determined by HPLC using UV–vis and MS detection after previous derivatization with diphenic anhydride. The alcoholic fraction was obtained by saponification, extraction and TLC (according to the European Union official procedure). Derivatization was performed in tetrahydrofuran in the presence of suspended grinded urea, which increases the reaction rate and yield. Derivatized extracts were chromatographed on a C8 column using gradient elution with acetonitrile/water mixtures containing 0.1% acetic acid, with UV–vis followed by negative-ion mode MS detection. Using linear discriminant analysis of t…

Resolution (mass spectrometry)Fraction (chemistry)Chemical FractionationSensitivity and SpecificityBiochemistryHigh-performance liquid chromatographyMass SpectrometryAnalytical ChemistryAcetic acidchemistry.chemical_compoundPlant Oilsmedia_common.cataloged_instanceEuropean unionDerivatizationChromatography High Pressure Liquidmedia_commonChromatographyEsterificationOrganic ChemistryExtraction (chemistry)Reproducibility of ResultsGeneral MedicineModels ChemicalchemistryAlcoholsMultivariate AnalysisDibenzoxepinsSaponificationJournal of Chromatography A
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