Search results for "Multivariate analysis"

showing 10 items of 1076 documents

Clinical approach to the analysis of causes of death in the first two years of life of very‐low‐birthweight infants in a multicentre setting

1997

Mortality in the first 2 years of 634 very-low-birthweight infants admitted to eight neonatal intensive care units in Italy, and the factors associated with the net probability of death from each cause, were studied by means of the Cox proportional hazard model. A clinical classification of the causes of death was used. Overall mortality was 33.7% (intercentre range 12.6-52.9%). The highest cause-specific mortality rates were observed for respiratory problems, intra-ventricular haemorrhage (IVH) and infections (14.5%, 6.3% and 5.7% respectively). The leading causes of death were respiratory problems and IVH in the first week of life, infections from the second week up to the end of the firs…

MalePediatricsmedicine.medical_specialtyEpidemiologyInfant Premature DiseasesCongenital AbnormalitiesRisk FactorsCause of DeathIntensive Care Units NeonatalIntensive careOdds RatiomedicineHumansInfant Very Low Birth WeightLife TablesProspective StudiesProspective cohort studyProportional Hazards ModelsCause of deathProportional hazards modelbusiness.industryMortality rateInfant NewbornGestational ageOdds ratiomedicine.diseaseItalyBronchopulmonary dysplasiaMultivariate AnalysisPediatrics Perinatology and Child HealthFemalebusinessPaediatric and Perinatal Epidemiology
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Epidemiology and Characteristics of Episodic Breathlessness in Advanced Cancer Patients. An Observational Study

2016

Abstract Context Episodic breathlessness is a relevant aspect in patients with advanced cancer. Objectives The aim of this study was to assess the different aspects of this clinical phenomenon. Methods A consecutive sample of patients with advanced cancer admitted to different settings for a period of six months was surveyed. The presence of background breathlessness and episodic breathlessness, their intensity (numerical scale 0–10), and drugs used for treatment were collected. Factors inducing episodic breathlessness and its influence on daily activities were investigated. Results Of 921 patients, 29.3% ( n  = 269) had breathlessness and 134 patients (49.8%) were receiving drugs for backg…

MalePediatricsmedicine.medical_specialtyPalliative careActivities of daily livingTime FactorsEpisodic breathlessneSettore MED/41 - AnestesiologiaContext (language use)advanced cancer; dyspnea; Episodic breathlessness; opioids; palliative care; Anesthesiology and Pain Medicine; Neurology (clinical); Nursing (all)2901 Nursing (miscellaneous)DiseaseComorbidityepisodic breathlessness; advanced cancer; dyspnea; opioids; palliative care03 medical and health sciencesPulmonary Disease Chronic Obstructive0302 clinical medicineNeoplasmsEpidemiologyActivities of Daily LivingmedicinePrevalenceHumansadvanced cancer030212 general & internal medicineKarnofsky Performance StatusGeneral NursingNursing (all)2901 Nursing (miscellaneous)Agedpalliative careEpisodic breathlessnessbusiness.industryEpisodic breathlessness; advanced cancer; dyspnea; opioids; palliative careopioidsCardiovascular Agentsrespiratory systemMiddle Ageddyspneamedicine.diseaseComorbidityAnesthesiology and Pain Medicine030220 oncology & carcinogenesisCardiovascular agentMultivariate AnalysisopioidObservational studyFemaleNeurology (clinical)business
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Predictors of clinical events occurring during hospital stay among elderly patients admitted to medical wards in Italy.

2016

Abstract Background Clinical events occurring during hospital stay are independent predictors of prolonged hospitalization, in-hospital mortality and readmission among elderly patients admitted to medical wards. Purpose To identify predictors of intercurrent clinical events (ICE) during hospital stay among the main demographic, functional and clinical characteristics assessed at hospital admission in a multicenter sample of elderly inpatients in Italy. Methods This observational prospective cohort study was conducted in 66 internal and geriatric medicine hospital wards in 2010. It enrolled 1267 inpatients aged 65 years or older living at home before hospitalization. Multivariable Poisson re…

MalePediatricsmedicine.medical_specialtySettore MED/09 - Medicina InternaFevermedicine.medical_treatmentWater-Electrolyte ImbalanceRisk AssessmentUrinary catheterizationBody Temperature03 medical and health sciencessymbols.namesake0302 clinical medicineRisk FactorsInternal MedicinemedicineOdds RatioHumans030212 general & internal medicinePoisson regressionPoisson DistributionProspective StudiesProspective cohort studyAgedGeriatricsAged 80 and overbusiness.industry030503 health policy & servicesAnemiaArrhythmias CardiacProton Pump InhibitorsOdds ratioPneumoniamedicine.diseaseComorbidityHospitalizationItalyRelative riskEmergency medicineMultivariate AnalysisUrinary Tract InfectionssymbolsElderly Intercurrent clinical events Adverse events REPOSI HospitalizationObservational studyFemale0305 other medical sciencebusinessUrinary CatheterizationImmunosuppressive AgentsEuropean journal of internal medicine
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Comparing Long-Acting Antipsychotic Discontinuation Rates Under Ordinary Clinical Circumstances: A Survival Analysis from an Observational, Pragmatic…

2021

Background Recent guidelines suggested a wider use of long-acting injectable antipsychotics (LAI) than previously, but naturalistic data on the consequences of LAI use in terms of discontinuation rates and associated factors are still sparse, making it hard for clinicians to be informed on plausible treatment courses. Objective Our objective was to assess, under real-world clinical circumstances, LAI discontinuation rates over a period of 12 months after a first prescription, reasons for discontinuation, and associated factors. Methods The STAR Network ‘Depot Study’ was a naturalistic, multicentre, observational prospective study that enrolled subjects initiating a LAI without restrictions …

MalePediatricsrespectively)0302 clinical medicineDelayed-Action PreparationBrief Psychiatric Rating ScalePharmacology (medical)he STAR Network ‘Depot Study’ prospectively followed 394 subjects initiating treatment with long-acting injections (LAIs) of antipsychotics under naturalistic conditions for 12 months. LAI discontinuation was frequent in everyday clinical practice in ItalyOriginal Research ArticleProspective StudiesProspective cohort studytreatmentMental DisordersHazard ratiowhereas more than half of participants initiating risperidone LAI and olanzapine LAI discontinued during the 12 months of follow-up (51.4 and 62.5%Psychiatric Status Rating ScaleMiddle Agedside efectsPsychiatry and Mental healthItalyMental DisorderFemalehe STAR Network ‘Depot Study’ prospectively followed 394 subjects initiating treatment with long-acting injections (LAIs) of antipsychotics under naturalistic conditions for 12 months. LAI discontinuation was frequent in everyday clinical practice in Italy occurring in almost 40% of the entire sample; side efects participant refusal to continue LAIs and LAIs no longer being required were the most frequently reported reasons for discontinuation. Paliperidone LAI and aripiprazole LAI were the least discontinued medications (33.9 and 35.4% respectively) whereas more than half of participants initiating risperidone LAI and olanzapine LAI discontinued during the 12 months of follow-up (51.4 and 62.5% respectively). In multivariate analysis being prescribed olanzapine LAI and poor medication adherence at baseline were signifcantly associated with higher discontinuation risk.HumanAntipsychotic Agentsmedicine.drugPsychopathologyAdultmedicine.medical_specialtyDiscontinuationFollow-Up StudieMedication Adherence03 medical and health sciencesmedicineHumansPaliperidoneAdverse effectSettore MED/25 - Psichiatriadiscontinuation ratesPsychiatric Status Rating Scalesrespectively). In multivariate analysisbusiness.industryLong-Acting Antipsychoticlong-acting injectable antipsychoticsSurvival AnalysisConfidence intervalparticipant refusal to continue LAIs and LAIs no longer being required were the most frequently reported reasons for discontinuation. Paliperidone LAI and aripiprazole LAI were the least discontinued medications (33.9 and 35.4%030227 psychiatryDiscontinuationProspective StudieAntipsychotic Agentoccurring in almost 40% of the entire sampleDelayed-Action PreparationsNeurology (clinical)business030217 neurology & neurosurgerybeing prescribed olanzapine LAI and poor medication adherence at baseline were signifcantly associated with higher discontinuation riskFollow-Up Studies
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Systolic Blood Pressure Variation and Mean Heart Rate Is Associated With Cognitive Dysfunction in Patients With High Cardiovascular Risk

2015

Abstract— Elevated systolic blood pressure (SBP) correlates to cognitive decline and incident dementia. The effects of heart rate (HR), visit to visit HR variation, and visit to visit SBP variation are less well established. Patients without preexisting cognitive dysfunction (N=24 593) were evaluated according to mean SBP, SBP visit to visit variation (coefficient of variation [standard deviation/mean×100%], CV), mean HR, and visit to visit HR variation (HR-CV) in the Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial and the Telmisartan Randomized Assessment Study in ACE Intolerant Subjects with Cardiovascular Disease. Cognitive function was assessed with min…

MalePredictive Value of TestAngiotensin-Converting Enzyme InhibitorsBlood PressureBenzimidazoleBenzoatesRamiprilRetrospective StudieHeart RateRisk FactorsCardiovascular DiseaseTelmisartanCognitive declineMultivariate AnalysiRandomized Controlled Trials as TopicAged 80 and overmedicine.diagnostic_testIncidenceMiddle AgedstrokeAntihypertensive Agentmyocardial infarctionCardiovascular DiseasesHypertensionCardiologyDrug Therapy CombinationFemaleHumanmedicine.drugRamiprilmedicine.medical_specialtyBenzoateFollow-Up StudieCognition DisorderPredictive Value of TestsInternal medicineHeart rateInternal MedicinemedicineHumansDementiaAntihypertensive AgentsAgedRetrospective StudiesMini–Mental State Examinationbusiness.industryRisk FactorAngiotensin-Converting Enzyme InhibitorOdds ratiomedicine.diseaseConfidence intervalBlood pressureMultivariate AnalysisPhysical therapyBenzimidazolesCognition DisordersbusinessFollow-Up StudiesHypertension
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Predictors of survival in patients with advanced hepatocellular carcinoma who permanently discontinued sorafenib

2015

Treatment with sorafenib of patients with advanced hepatocellular carcinoma is challenged by anticipated discontinuation due to tumor progression, liver decompensation, or adverse effects. While postprogression survival is clearly determined by the pattern of tumor progression, understanding the factors that drive prognosis in patients who discontinued sorafenib for any reason may help to improve patient management and second-line trial design. Patients consecutively admitted to three referral centers who were receiving best supportive care following permanent discontinuation of sorafenib for any reason were included. Postsorafenib survival (PSS) was calculated from the last day of treatmen…

MalePredictive Value of TestGastroenterologyCohort StudiesAntineoplastic AgentProspective StudiesProspective cohort studyMultivariate AnalysiLiver NeoplasmsHepatitis CMiddle AgedSorafenibItalyLiver NeoplasmHepatocellular carcinomaFemaleSurvival Analysimedicine.drugHumanSorafenibNiacinamidePhenylurea Compoundmedicine.medical_specialtyCarcinoma HepatocellularDrug-Related Side Effects and Adverse ReactionsSettore MED/12 - GASTROENTEROLOGIAReproducibility of ResultAntineoplastic AgentsRisk AssessmentPredictive Value of TestsInternal medicinemedicineHumansNeoplasm InvasivenessSurvival analysisAgedNeoplasm StagingNeoplasm InvasiveneAnalysis of VarianceHepatologyPerformance statusbusiness.industryPhenylurea CompoundsPatient SelectionCarcinomaSettore MED/09 - MEDICINA INTERNAReproducibility of ResultsHepatocellularHepatologymedicine.diseaseSurvival AnalysisSurgeryDiscontinuationProspective StudieWithholding TreatmentMultivariate AnalysisCohort StudiebusinessDrug-Related Side Effects and Adverse Reaction
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Inhibition of Proteasomal Glucocorticoid Receptor Degradation Restores Dexamethasone-Mediated Stabilization of the Blood–Brain Barrier After Traumati…

2013

To establish the molecular background for glucocorticoid insensitivity, that is, failure to reduce edema formation and to protect blood-brain barrier integrity after acute traumatic brain injury.Controlled animal study.University research laboratory.Male C57Bl/6N mice.Mechanical brain lesion by controlled cortical impact.Our study demonstrates that 1) proteasomal glucocorticoid receptor degradation is established in brain endothelial cells after traumatic brain injury as a form of posttranslational glucocorticoid receptor modification; 2) inhibition of the proteasomal degradation pathway with bortezomib (0.2 mg/kg) in combination with the glucocorticoid dexamethasone (10 mg/kg) by subcutane…

MaleProteasome Endopeptidase ComplexTraumatic brain injuryBlotting WesternBrain EdemaPharmacologyReal-Time Polymerase Chain ReactionCritical Care and Intensive Care MedicineBlood–brain barrierSensitivity and SpecificityDexamethasoneStatistics NonparametricBortezomibMiceRandom AllocationReceptors GlucocorticoidGlucocorticoid receptorReference ValuesmedicineAnimalsRNA MessengerReceptorDexamethasonebusiness.industryBortezomibmedicine.diseaseBoronic AcidsImmunohistochemistryMice Inbred C57BLBlotDisease Models Animalmedicine.anatomical_structureBlood-Brain BarrierBrain InjuriesPyrazinesMultivariate AnalysisBlood Gas AnalysisbusinessGlucocorticoidmedicine.drugCritical Care Medicine
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A happiness degree predictor using the conceptual data structure for deep learning architectures

2017

Abstract Background and Objective: Happiness is a universal fundamental human goal. Since the emergence of Positive Psychology, a major focus in psychological research has been to study the role of certain factors in the prediction of happiness. The conventional methodologies are based on linear relationships, such as the commonly used Multivariate Linear Regression (MLR), which may suffer from the lack of representative capacity to the varied psychological features. Using Deep Neural Networks (DNN), we define a Happiness Degree Predictor (H-DP) based on the answers to five psychometric standardized questionnaires. Methods: A Data-Structure driven architecture for DNNs (D-SDNN) is proposed …

MalePsychometricsmedia_common.quotation_subjectEmotionsHappiness050109 social psychologyHealth Informatics02 engineering and technologyModels PsychologicalMachine learningcomputer.software_genrePredictive Value of TestsSurveys and QuestionnairesBayesian multivariate linear regressionAdaptation Psychological0202 electrical engineering electronic engineering information engineeringCIENCIAS DE LA COMPUTACION E INTELIGENCIA ARTIFICIALHumans03.- Garantizar una vida saludable y promover el bienestar para todos y todas en todas las edades0501 psychology and cognitive sciencesDimension (data warehouse)HappinessHappiness-Degree Predictor (H-DP)media_commonMathematicsArtificial neural networkbusiness.industryPsychological researchDeep learning05 social sciencesSocial SupportDeep learningOutcome (probability)Computer Science ApplicationsData-structure driven deep neural network (D-SDNN)Cross-Sectional StudiesMultivariate AnalysisHappinessORGANIZACION DE EMPRESASFemale020201 artificial intelligence & image processingArtificial intelligencePositive psychologybusinessMATEMATICA APLICADAcomputerAlgorithmsMedical InformaticsStress PsychologicalSoftware
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High-resolution computed tomography quantitation of emphysema is correlated with selected lung function values in stable COPD

2012

<b><i>Background:</i></b> The literature shows conflicting results when high-resolution computed tomography (HRCT) scores of emphysema were correlated with different indices of airflow obstruction. <b><i>Objectives:</i></b> We correlated HRCT scores of emphysema with different indices of airflow obstruction. <b><i>Methods:</i></b> We performed HRCT of the chest in 59 patients, all smokers or ex-smokers, with stable chronic obstructive pulmonary disease of different severity [GOLD stages I–IV; mean age ± SD 67.8 ± 7.3 years; pack/years 51.0 ± 34.6; percent predicted forced expiratory volume in 1 s (FEV<sub>1</su…

MalePulmonary and Respiratory MedicineEmphysema COPD High-resolution computed tomography Lung structural alterationsVital capacityHigh-resolution computed tomographyPulmonary diseaseLung structural alterationsSeverity of Illness IndexPulmonary Disease Chronic ObstructiveFEV1/FVC ratioSeverity of illnessmedicineHumansCOPDLung volumesLung functionHigh-resolution computed tomographyAgedEmphysemaCOPDmedicine.diagnostic_testbusiness.industryChronic obstructive pulmonary diseaseSmokingrespiratory systemmedicine.diseaseBronchodilator AgentsRespiratory Function Testsrespiratory tract diseasesPulmonary EmphysemaAnesthesiaMultivariate AnalysisFemaleTomography X-Ray ComputedbusinessNuclear medicineChronic obstructive pulmonary disease; Emphysema; High-resolution computed tomography; Lung structural alterations;
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Predictors of Ineffective Cough during a Chest Infection in Patients with Stable Amyotrophic Lateral Sclerosis

2007

In patients with neuromuscular diseases, a chest infection is associated with a reduction in respiratory muscle function that may result in decreased cough effectiveness.To determine if a clinical or functional parameter in patients with amyotrophic lateral sclerosis (ALS) in a stable condition could predict spontaneous cough ineffectiveness during a respiratory tract infection.Forty consecutive patients with ALS referred to our Respiratory Care Unit were studied during a one-year follow-up.FEV(1), FVC, FEV(1)/FVC, peak cough flow (PCF), peak velocity time (PVT), maximum inspiratory and expiratory pressures, and bulbar dysfunction evaluation using the Norris scale bulbar subscore (NBS). A t…

MalePulmonary and Respiratory MedicineSpirometrymedicine.medical_specialtyNeuromuscular diseaseCritical Care and Intensive Care MedicineSensitivity and SpecificityFEV1/FVC ratioIntensive caremedicineRespiratory muscleHumansAmyotrophic lateral sclerosisRespiratory Tract InfectionsAgedmedicine.diagnostic_testbusiness.industryAmyotrophic Lateral SclerosisMiddle Agedmedicine.diseaserespiratory tract diseasesSurgeryMucusmedicine.anatomical_structureCoughROC CurveSpirometryAnesthesiaMultivariate AnalysisFemaleRespiratory InsufficiencybusinessRespiratory careRespiratory tractAmerican Journal of Respiratory and Critical Care Medicine
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