Search results for "Muri"

showing 10 items of 289 documents

Anti-inflammatory Function of High-Density Lipoproteins via Autophagy of IκB Kinase

2015

Background & Aims: Plasma levels of high-density lipoprotein (HDL) cholesterol are frequently found decreased in patients with inflammatory bowel disease (IBD). Therefore, and because HDL exerts anti-inflammatory activities, we investigated whether HDL and its major protein component apolipoprotein A-I (apoA-I) modulate mucosal inflammatory responses in vitro and in vivo. Methods: The human intestinal epithelial cell line T84 was used as the in vitro model for measuring the effects of HDL on the expression and secretion of tumor necrosis factor (TNF), interleukin-8 (IL-8), and intracellular adhesion molecule (ICAM). Nuclear factor-κB (NF-κB)-responsive promoter activity was studied by …

WT wild typeApolipoprotein BEMSA electrophoretic mobility shift assayMPO myeloperoxidaseIκB kinaseDSS dextran sodium sulphatemTOR the mammalian target of rapamycinRT-PCR real-time polymerase chain reactionNF-κBchemistry.chemical_compound540 ChemistryApoA-I apolipoprotein A-I10038 Institute of Clinical ChemistryOriginal ResearchTNF tumor necrosis factorbiologyIBD inflammatory bowel diseaseChemistryGastroenterologyMyeloperoxidase10076 Center for Integrative Human PhysiologyMEICS murine endoscopic index of colitis severityTumor necrosis factor alphalipids (amino acids peptides and proteins)3-MA 3-methyl adenineNF-κB nuclear factor κBHDL high-density lipoproteinLC3II light chain 3 IIPBS phosphate-buffered salinep-IKK phosphorylated IκB kinase610 Medicine & healthICAM intracellular adhesion molecule246-Trinitrobenzenesulfonic acidTg transgenicmedicineAutophagyCD Crohn’s disease2715 GastroenterologyColitislcsh:RC799-869KO knockoutHepatologyApolipoprotein A-IAutophagyInflammatory Bowel DiseaseTNBS 246-trinitrobenzenesulfonic acidmedicine.diseaseMolecular biologyIL interleukinsiRNA small interfering RNAPI-3 phosphatidylinositol-3Immunologybiology.protein2721 Hepatologylcsh:Diseases of the digestive system. GastroenterologyPFA paraformaldehydeLipoproteinDAPI 4′6-diamidino-2-phenylindoleCMGH Cellular and Molecular Gastroenterology and Hepatology
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Evolution climatique au Jurassique inférieur (Sinémuriensupérieur) de la zone Nord-Ouest européenne, déduit de laminéralogie des argiles et des isoto…

2021

National audience; L’étude des minéraux argileux et des isotopes stables (carbone) du Sinémuriensupérieur du bassin de Cardigan Bay (forage de Mochras, Pays de Galles) et du bassinde Paris (forage de Montcornet, France) permet de mettre en évidence les conditionsenvironnementales et climatiques dominantes à cette période. Dans les deux bassins,situés à des paléolatitudes proches (30 à 35°N), les assemblages de minéraux argileuxcomprennent des chlorites, des illites, des interstratifiés illite-smectite (IS R1), dessmectites et des kaolinites dans des proportions variables. L'influence de la diagenèsed’enfouissement et de l'authigénèse étant négligeable dans les deux forages, lesminéraux argi…

[SDU.STU.CL] Sciences of the Universe [physics]/Earth Sciences/ClimatologySinémurien[SDU.STU.GC]Sciences of the Universe [physics]/Earth Sciences/Geochemistry[SDU.STU.CL]Sciences of the Universe [physics]/Earth Sciences/Climatology[SDU.STU.GC] Sciences of the Universe [physics]/Earth Sciences/GeochemistrypaléoclimatJurassiqueisotopes du carboneargiles[SDU.STU.MI] Sciences of the Universe [physics]/Earth Sciences/Mineralogy[SDU.STU.MI]Sciences of the Universe [physics]/Earth Sciences/Mineralogy
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Evolution climatique au Jurassique inférieur (Sinémurien supérieur) de la zone Nord-Ouest européenne, déduit de la minéralogie des argiles et des iso…

2021

International audience

[SDU] Sciences of the Universe [physics]Sinémurien[SDU]Sciences of the Universe [physics]paléoclimatJurassiqueisotopes du carboneargilesComputingMilieux_MISCELLANEOUS
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Priežu sveķotājkoksngrauža Nothorhina muricata (Dalman, 1817) aktuālo sastopamību ietekmējošie faktori

2021

Priežu sveķotājkoksngrauzis (Nothorhina muricata) ir reti sastopama un maz pētīta suga gan Latvijā, gan Eiropā, kas tiek izmantota kā dabisko mežu indikatorsuga. Latvijā šī suga iekļauta īpaši aizsargājamo sugu sarakstā. Darba mērķis ir noskaidrot priežu sveķotājkoksngrauža aktuālo sastopamību uz priedēm, un kādi faktori to varētu ietekmēt. Par pētījuma teritoriju izvēlēts Slīteres NP, jo tajā ir viena no zināmajām vietām Latvijā ar lielu populācijas atradņu skaitu. Pētījumā izmantota atkārtotā izskreju uzskiates metode, kurā izmantoti dati par 107 kokiem. Jauno izskreju skaits ir saistīts ar veco izskreu skaitu un koka sasveķojuma pakāpi. Sugas klātbūtni ietekmē koka slīpums, stumbra apkār…

aktuālā sastopamībaNothorhina muricataBioloģijaatkārtotas izskreju uzskaitesSlīteres nacionālais parks
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The Upper Sinemurian ammonite succession in the Sierra Madre Oriental (Mexico).

2009

International audience; In the Sierra Madre Oriental (Mexico), the biostratigraphic subdivision of the Upper Sinemurian can be refined. It has been possible to differentiate 11 horizons from the upper Obtusum Zone to the top of the Raricostatum Zone which are correlated with the NW European standard zonation. The index species of each horizon is figured.

ammonitesSierra Madre OrientalEarly Jurassicbiostratigraphy[SDU.STU.PG] Sciences of the Universe [physics]/Earth Sciences/PaleontologySinemurianMexico[ SDU.STU.PG ] Sciences of the Universe [physics]/Earth Sciences/Paleontology
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Chemical Profile and Biological Activity of Cherimoya (Annona cherimola Mill.) and Atemoya (Annona atemoya) Leaves

2020

Annona cherimola (Cherimoya) and Annona atemoya (Atemoya) are tropical plants known for their edible fruit. Scientific data suggest that their leaves, used in traditional medicine in the form of teas or infusions without evidence of toxicity, contain several bioactive compounds. However, only Annona muricata among all the Annona species is currently used in the nutraceutical field, and its dried leaves are marketed for tea preparation. In this work, we explored the nutraceutical potential of Atemoya and Cherimoya leaves, by evaluating their chemical profile and functional properties. Phytochemical analyses showed large amounts of phenolic compounds, in particular proanthocyanidins, and iden…

antiproliferative activity030309 nutrition & dieteticsPhytochemicalsPharmaceutical ScienceApoptosisAnnona cherimolaalkaloidsArticleAnnonaAnalytical ChemistryHPLC-DAD-MS/MSlcsh:QD241-44103 medical and health sciences0404 agricultural biotechnologyNutraceuticallcsh:Organic chemistrySettore BIO/10 - BiochimicaNeoplasmsDrug DiscoveryTumor Cells CulturedHumansPhysical and Theoretical ChemistryAtemoyaAnnona muricatapolyphenolsCell Proliferation0303 health sciencesbiologyPlant ExtractsOrganic ChemistryAlkaloids; Antioxidants; Antiproliferative activity; HPLC-DAD-MS/MS; Polyphenolsfood and beverages04 agricultural and veterinary sciencesbiology.organism_classification040401 food sciencePlant LeavesSettore BIO/18 - GeneticaHorticultureantioxidantsProanthocyanidinPhytochemicalChemistry (miscellaneous)PolyphenolMolecular MedicineAnnonaMolecules
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Behaviour of cyclic bank voles under risk of mustelid predation: do females avoid copulations?

1993

Mustelid odours have been shown to suppress breeding in captive bank voles (Clethrionomys glareolus) from cyclic populations (Ylonen 1989; Ylonen and Ronkainen 1994). The mechanism behind the suppression is unknown. Based on a series of behavioural trials and breeding experiments with pairs of bank voles in breeding condition, we suggest that the primary cause for breeding suppression is a change in female mating behaviour. Experimental female-male pairs (n=34) exposed to mustelid odour decreased their general activity compared to control pairs (n=34). When encountering males in behavioural trials, females exposed to stoat odour were more aggressive and actively avoided precopulatory behavi…

biologyEcologymedia_common.quotation_subjectZoologyGeneral activityReproductionMatingbiology.organism_classificationEcology Evolution Behavior and SystematicsClethrionomys glareolusmedia_commonPredationMuridaeOecologia
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Ophiobolin Sesterterpenoids and Pyrrolidine Alkaloids from the Sponge-Derived Fungus Aspergillus ustus

2011

Chemical examination of the fungus Aspergillus ustus isolated from the Mediterranean sponge Suberites domuncula yielded the five new ophiobolin-type sesterterpenoids 1–5 and the two new pyrrolidine alkaloids 6 and 7, together with the known compound aurantiamine and cerebroside D. The structures of the new compounds were unambiguously elucidated on the basis of extensive spectroscopic-data analysis (1D- and 2D-NMR, MS, and UV) and comparison with literature data. All compounds were evaluated for their cytotoxicity against murine lymphoma cell line L5178Y.

biologyMurine lymphomaChemistryStereochemistryOrganic ChemistryFungusbiology.organism_classificationBiochemistryCatalysisCerebrosidePyrrolidineInorganic ChemistrySuberites domunculaSpongechemistry.chemical_compoundBiochemistryAspergillus ustusDrug DiscoveryPhysical and Theoretical ChemistryCytotoxicityHelvetica Chimica Acta
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A prospective observational study on oral administration of Ellagic Acid and Annona Muricata in patients affected by non-muscle invasive bladder canc…

2021

Introduction: BCG and MMC shortage and Covid-19 pandemic, more recently, limit accessibility to maintenance regimen in intravesical prophylaxis against recurrence of non-muscle invasive bladder cancer (NMIBC). Ellagic acid (EA) and Annona muricata (AM) exert antitumor activity against different human tumours. An observational prospective study on the prophylactic effect of oral administration of EA+AM in patients avoiding maintenance regimen is presented. Materials and methods: Patients affected by NMIBC and not undergoing maintenance after a 6-week course of intravesical prophylaxis with MMC or BCG were entered. Tis and very high-risk tumours were excluded. After informed consent, the pati…

bladder carcinomamedicine.medical_specialtybacillus calmette-guerinmedicine.medical_treatment030232 urology & nephrologyAdministration Oralnutraceuticsintravesical instillationGastroenterologyAnnonalaw.inventionannona muricata03 medical and health sciences0302 clinical medicineAdjuvants ImmunologicRandomized controlled trialellagic acidOral administrationlawInternal medicineCytologymedicineHumansNeoplasm InvasivenessProspective StudiesProspective cohort studyPandemicsChemotherapyBladder cancermedicine.diagnostic_testSARS-CoV-2business.industryCOVID-19General MedicineCystoscopymedicine.diseaseRegimenAdministration IntravesicalUrinary Bladder Neoplasms030220 oncology & carcinogenesisBCG VaccineNeoplasm Recurrence Localbusinessannona muricata; bacillus calmette-guerin; bladder carcinoma; ellagic acid; intravesical instillation; nutraceuticsUrologia Journal
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Inflammation and remodelling of distal airways in a murine model of chronic experimental asthma

2005

business.industryMurine modelImmunologyImmunologymedicineImmunology and AllergyInflammationmedicine.symptommedicine.diseasebusinessAsthmaJournal of Allergy and Clinical Immunology
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