Search results for "Myc"
showing 10 items of 3773 documents
The Major Heat Shock Proteins, Hsp70 and Hsp90, in 2-Methoxyestradiol-Mediated Osteosarcoma Cell Death Model
2020
2-Methoxyestradiol is one of the natural 17&beta
Study of the impact of viticultural practices on arbuscular mycorrhizal fungi associated with vines
2021
Arbuscular mycorrhiza, a mutualistic symbiosis established between plants andarbuscular mycorrhizal fungi (AMF), providesmany ecosystem services such as improved soilstructure, increased plant growth and nutrition,and improved tolerance to biotic and abioticstresses. However, intensive agricultural practicesand the use of phytosanitary products as forexample herbicide and fungicides, have a strongimpact on communities of soil microorganisms,including arbuscular mycorrhizal fungi, as well ason biological mechanisms within the ecosystem.This thesis wotk is part of the European Biovineproject supported by the European Commissionthrough the CORE Organic Cofund.The aim of this research work was …
Mucocutaneous diseases with manifestations in the head and neck region: 24 years of experience in a Dermatology service
2023
This study aimed to evaluate the clinicopathological features of mucocutaneous diseases with manifestation in the head and neck region. A retrospective analysis of a dermatology reference center database was carried out. Over 24 years. Clinicopathological data were collected from medical records and the data was analyzed by descriptive statistics. A total of 11.538 medical records were analyzed, being 152 cases of mucocutaneous diseases with manifestations in the head and neck region. Cutaneous lupus erythematosus was the most prevalent diagnosis (66.4%). Face (44.1%), females (79.6%), and patients with 45 years mean age were the most common features. In the oral cavity, the most affected r…
A novel intrinsically disordered outer membrane lipoprotein ofAggregatibacter actinomycetemcomitansbinds various cytokines and plays a role in biofil…
2017
Intrinsically disordered proteins (IDPs) do not have a well-defined and stable 3-dimensional fold. Some IDPs can function as either transient or permanent binders of other proteins and may interact with an array of ligands by adopting different conformations. A novel outer membrane lipoprotein, bacterial interleukin receptor I (BilRI) of the opportunistic oral pathogen Aggregatibacter actinomycetemcomitans binds a key gatekeeper proinflammatory cytokine interleukin (IL)-1b. Because the amino acid sequence of the novel lipoprotein resembles that of fibrinogen binder A of Haemophilus ducreyi, BilRI could have the potential to bind other proteins, such as host matrix proteins. However, from th…
Molecular mechanisms of MYCN-dependent apoptosis and the MDM2-p53 pathway: an Achille’s heel to be exploited for the therapy of MYCN amplified neurob…
2012
The p53 oncosuppressor is very seldom mutated in neuroblastoma, but several mecha- nisms cooperate to its functional inactivation in this tumor. Increased MDM2 levels, due to genetic amplification or constitutive inhibition of p14ARF, significantly contribute to this event highlighting p53 reactivation as an attractive perspective for neuroblastoma treat- ment. In addition to its role in tumorigenesis, MYCN sensitizes untransformed and cancer cells to apoptosis. This is associated to a fine modulation of the MDM2-p53 pathway Indeed MYCN induces p53 and MDM2 transcription, and, by evoking a DNA damage response (DDR), it stabilizes p53 and its proapoptotic kinase Homeodomain Interacting Prote…
cayol_texte_tables_figures_ESM from Borrelia afzelii alters reproductive success in a rodent host
2018
Supplementary material from "Borrelia afzelii alters reproductive success in a rodent host". Detailed material and methods, supplementary tables, figures and results.
Research data of article: "Sympatric Ixodes-tick species: pattern of distribution and pathogen transmission within wild rodent populations"
2018
Longitudinal monitoring of bank voles as well as their ticks and tick-borne pathogens in Central Finland, carried out in 2012.
Augsnes faktoru ietekme uz arbuskulāro mikorizu pelēkajās kāpās rietumu Latvijas piekrastē
2015
Arbuskulārā mikoriza palīdz augiem izdzīvot dažādos neparastos apstākļos pie lieliem traucējumiem. Kas ietekmē mikorizu? Darbā ir apkopoti dati par mikorizas frekvenci, intensitāti un arbuskulu daudzumu augu saknēs, kā arī dati par augsni. Analizējot mikorizu, augu sugas un augsnes datu tiek aplūkota sakarība starp šiem trim faktoriem. No tā izriet, ka mikorizas esamību ietekmē, gan augsnes faktori, gan pats augs.
Botany_Theory Lectures_Pharmacy degree-UV_IsaacGarridoBenavent
2023
El document forma part dels materials docents programats mitjançant l'ajut del Servei de Política Lingüística de la Universitat de València. This document contains the teaching material corresponding to the subject Botany, which is taught in the first year of the Degree in Pharmacy at the University of Valencia. More specifically, this material is designed for the high performance group (ARA). It contains basic botany lessons (structure and reproduction) as well as others dedicated to describing the diversity of different botanical groups, such as plants, algae and fungi.