Search results for "Myocardial"

showing 10 items of 1323 documents

Association between HFE mutations and acute myocardial infarction: a study in patients from Northern and Southern Italy.

2003

There is interest in the role of iron in age-related diseases such as atherosclerosis. Tissue iron deposition could be harmful, because Fe(2+) can react with H(2)O(2) to form OH(-) radicals and Fe(2+) can react with O(2) to form reactive oxygen species. Free radicals react with cell membranes and cell organelles and could lead to the development of atherosclerosis by initiating lipid peroxidation. Hereditary hemochromatosis provides an opportunity for studying the effects of iron on cardiovascular disease. Some studies have shown that individuals who carried HFE mutations may be at greater risk of developing coronary heart disease than those without the mutations. In contrast, a large numbe…

Apolipoprotein EAdultMalePathologymedicine.medical_specialtySettore MED/09 - Medicina InternaGenotypePopulationApolipoprotein E4Mutation MissenseMyocardial InfarctionPhysiologyApolipoproteins EGene FrequencyGenotypeMedicineHumansAge FactorMyocardial infarctionAlleleeducationHemochromatosis ProteinMembrane ProteinMolecular BiologyAllele frequencyAgedAged 80 and overeducation.field_of_studybusiness.industryHistocompatibility Antigens Class ICase-control studyAge FactorsMembrane ProteinsCell BiologyHematologyMiddle Agedmedicine.diseaseItalyHereditary hemochromatosisCase-Control StudiesMolecular MedicineFemaleCase-Control StudiebusinessHumanBlood cells, moleculesdiseases
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Sharing pathogenetic mechanisms between acute myocardial infarction and Alzheimer's disease as shown by partially overlapping of gene variant profile…

2011

Abstract Gene variants that promote inflammation and cholesterol metabolism have been associated with acute myocardial infarction (AMI) and Alzheimer's disease (AD). We investigated a panel of relevant polymorphisms to distinguish genetic backgrounds for AMI and AD: IL10 -1082G/A, IL6 -174G/C, TNF -308G/A, IFNG +874T/A, SERPINA3 -51G/T, HMGCR -911C/A, APOE e2/3/4 (280 AMI cases, 257 AD cases, and 1307 population controls, all Italian (presumed risk alleles are shown in bold). Six genetic risk sets I to VI were identified by fuzzy latent classification: I had low risk; II and III had low risk before age 65 (II, III); low risk sets lacked pro-inflammatory alleles for HMGCR-TNF-APOE. Pro-infla…

Apolipoprotein EAdultMalePopulationMyocardial InfarctionDiseaseAlzheimer DiseaseRisk FactorsGenes OverlappingMedicineHumansSettore MED/05 - Patologia ClinicaGenetic Predisposition to DiseaseMyocardial infarctionAlleleeducationgenetic risk markers common soil alzheimer disease AMI GOM analysysGeneAgedGeneticsAged 80 and overeducation.field_of_studybusiness.industryGeneral NeuroscienceGene Expression ProfilingGenetic VariationGeneral MedicineMiddle Agedmedicine.diseasePsychiatry and Mental healthClinical PsychologyRelative riskImmunologyTumor necrosis factor alphaFemaleGeriatrics and Gerontologybusiness
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Automatic Myocardial Infarction Evaluation from Delayed-Enhancement Cardiac MRI Using Deep Convolutional Networks

2021

In this paper, we propose a new deep learning framework for an automatic myocardial infarction evaluation from clinical information and delayed enhancement-MRI (DE-MRI). The proposed framework addresses two tasks. The first task is automatic detection of myocardial contours, the infarcted area, the no-reflow area, and the left ventricular cavity from a short-axis DE-MRI series. It employs two segmentation neural networks. The first network is used to segment the anatomical structures such as the myocardium and left ventricular cavity. The second network is used to segment the pathological areas such as myocardial infarction, myocardial no-reflow, and normal myocardial region. The segmented …

Artificial neural networkComputer sciencebusiness.industryDeep learningPattern recognitionDelayed enhancementmedicine.diseaseSupport vector machineClinical informationcardiovascular systemmedicineLeft ventricular cavitySegmentationcardiovascular diseasesMyocardial infarctionArtificial intelligencebusiness
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Comparison of primary angioplasty with conservative therapy in patients with acute myocardial infarction and contraindications for thrombolytic thera…

1999

The benefit of primary angioplasty in patients with acute myocardial infarction (AMI) and contraindications for thrombolysis compared to a conservative regimen is still unclear. Out of 5,869 patients with AMI registered by the MITRA trial, 337 (5.7%) patients had at least one strong contraindication for thrombolytic therapy. Out of these 337 patients 46 (13.6%) were treated with primary angioplasty and 276 (86.4%) were treated conservatively. Patients treated conservatively were older (70 years vs. 60 years; P = 0.001), had a higher rate of a history with chronic heart failure (14.8% vs. 4.4%; P = 0.053), a higher heart rate at admission (86 beats/min vs. 74 beats/min; P = 0.001), and a hig…

Aspirinmedicine.medical_specialtybusiness.industrymedicine.medical_treatmentGeneral MedicineThrombolysismedicine.diseaseRegimenInternal medicineDiabetes mellitusHeart failureHeart ratemedicineCardiologyRadiology Nuclear Medicine and imagingMyocardial infarctionCardiology and Cardiovascular MedicinebusinessContraindicationmedicine.drugCatheterization and Cardiovascular Interventions
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Carotid plaque detection improves the predictve value of CHA2DS2-VASc score in patients with non-valvular atrial fibrilation: The ARAPACIS Study

2017

Abstract Background and aims Vascular disease (VD), as assessed by history of myocardial infarction or peripheral artery disease or aortic plaque, increases stroke risk in atrial fibrillation (AF), and is a component of risk assessment using the CHA 2 DS 2 -VASc score. We investigated if systemic atherosclerosis as detected by ultrasound carotid plaque (CP) could improve the predictive value of the CHA 2 DS 2 -VASc score. Methods We analysed data from the ARAPACIS study, an observational study including 2027 Italian patients with non-valvular AF, in whom CP was detected using Doppler Ultrasonography. Results VD was reported in 351 (17.3%) patients while CP was detected in 16.6% patients. Ad…

Atherosclerosis Atrial fibrillation Carotid plaque CHA2DS2-VASc score Stroke Vascular diseaseCarotid Artery DiseasesMaleAtherosclerosis; Atrial fibrillation; Carotid plaque; CHA2DS2-VASc score; Stroke; Vascular disease; Aged; Aged 80 and over; Ankle Brachial Index; Atrial Fibrillation; Carotid Artery Diseases; Female; Humans; Incidence; Italy; Male; Plaque Atherosclerotic; Retrospective Studies; Risk Factors; Survival Rate; Ultrasonography Doppler; Risk Assessment; Cardiology and Cardiovascular Medicine030204 cardiovascular system & hematologyatrialf fibrillation0302 clinical medicineRetrospective StudieRisk FactorsCarotid artery diseaseAtherosclerosis; Atrial fibrillation; Carotid plaque; CHA; 2; DS; 2; -VASc score; Stroke; Vascular disease; Aged; Aged 80 and over; Ankle Brachial Index; Atrial Fibrillation; Carotid Artery Diseases; Female; Humans; Incidence; Italy; Male; Plaque Atherosclerotic; Retrospective Studies; Risk Factors; Survival Rate; Ultrasonography Doppler; Risk AssessmentAtrial Fibrillation80 and over030212 general & internal medicineMyocardial infarctionStrokeDSAtherosclerosis; Atrial fibrillation; CHA(2)DS(2)-VASc score; Carotid plaque; Stroke; Vascular disease; Aged; Aged 80 and over; Ankle Brachial Index; Atrial Fibrillation; Carotid Artery Diseases; Female; Humans; Incidence; Italy; Male; Plaque Atherosclerotic; Retrospective Studies; Risk Factors; Survival Rate; Ultrasonography Doppler; Risk AssessmentCHA 2 DS 2 -VASc scorePlaqueAtheroscleroticUltrasonographyAged 80 and overIncidenceDopplerAtrial fibrillationCarotid plaquePlaque AtheroscleroticStrokeSurvival RateItalyAtherosclerosiCHA(2)DS(2)-VASc scoreCardiologyartherosclerosis; atrial fibrillation; carotid plaque; CHA2DS2-VASc score; stroke; vascular disease; aged; aged 80 and over; ankle brachial index; atrialf fibrillation; carotid artery diseases; female; humans; incidence; italy; male; plaque atherosclerotic; retrospective studies; risk factors; survival rate; ultrasonography doppler; risk assessment; cardiology and cardiovascular medicineFemaleSettore SECS-S/01 - StatisticaCardiology and Cardiovascular MedicineHumanmedicine.medical_specialtyCHA2DS2-VASc score2Atherosclerosis; Atrial fibrillation; Carotid plaque; CHA 2 DS 2 -VASc score ; Stroke; Vascular disease; Aged; Aged 80 and over; Ankle Brachial Index; Atrial Fibrillation; Carotid Artery Diseases; Female; Humans; Incidence; Italy; Male; Plaque Atherosclerotic; Retrospective Studies; Risk Factors; Survival Rate; Ultrasonography Doppler; Risk Assessment; Cardiology and Cardiovascular MedicineSocio-culturaleVascular diseaseRisk Assessment-VASc score03 medical and health sciencesInternal medicinemedicineHumansAnkle Brachial Indexcardiovascular diseasesRisk factorSurvival rateAgedRetrospective StudiesCarotid Artery DiseaseVascular diseasebusiness.industryRisk FactorUltrasonography Dopplermedicine.diseaseAtherosclerosisartherosclerosisCHA2DS2–VASc scoreCHAAtherosclerosis; Atrial fibrillation; Carotid plaque; CHA; 2; DS; 2; -VASc score; Stroke; Vascular diseasebusiness
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Transmural myocardial ischaemia complicating recovery after dobutamine-atropine stress echocardiography in patients with non-significant coronary art…

2011

In the proposed selection of cases, traditional imaging is integrated with contemporary diagnostic tools available in the cath-lab to navigate the potential mechanisms underlying a very rare complication occurring in the recovery phase of dobutamine-atropine stress echocardiography. The data, collected in a time frame of nearly 15 years, provide interesting elements to possibly evolve from speculative considerations to plausible confirmation of the candidate pathophysiological mechanism mediating the occurrence of transmural myocardial ischaemia after beta-blockers administration.

AtropineMaleChest Painmedicine.medical_specialtyMyocardial ischaemiamedicine.drug_classAdrenergic beta-AntagonistsMyocardial IschemiaCoronary Artery DiseaseCoronary AngiographyCoronary artery diseaseElectrocardiographyInternal medicineStress EchocardiographyHumansMedicineRadiology Nuclear Medicine and imagingBeta blockerAgedbusiness.industryParasympatholyticsGeneral MedicineMiddle Agedmedicine.diseaseFractional Flow Reserve MyocardialAtropineCardiologyFemaleDobutamineCardiology and Cardiovascular MedicinebusinessComplicationCoronary physiologyEchocardiography Stressmedicine.drugEuropean Journal of Echocardiography
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Antimuscarinic action of quinidine on the heart? A study in myocardial preparations from cat hearts

1984

Quinidine exerts anticholinergic effects which have been ascribed to atropine-like properties of the drug. We have examined the effects of acetylcholine on the force of contraction in isolated heart muscle preparations from cats and compared the inhibitory effects of atropine with those of quinidine. The effects of acetylcholine were antagonized competitively in the presence of atropine. The Schild-plot yielded a straight line; the slope was not significantly different from unity. In the presence of quinidine, the concentration-response curve of acetylcholine was shifted to the right as with atropine, however, the Schild-plot yielded a regression line which was not linear; the slope was sta…

AtropineMaleQuinidineInotropemedicine.medical_specialtymedicine.drug_classAction PotentialsIn Vitro TechniquesPharmacologyParasympatholyticInternal medicinemedicineAnticholinergicAnimalsPhosphodiesterase inhibitorPharmacologyPapaverineChemistryCell MembraneParasympatholyticsMyocardial ContractionQuinidineAcetylcholineElectrophysiologyAtropineEndocrinologyCatsFemaleAcetylcholineResearch Articlemedicine.drugBritish Journal of Pharmacology
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Safety and feasibility of atropine added in patients with sub-maximal heart rate during exercise myocardial perfusion SPECT.

2006

Failure to reach 80% of maximal predicted heart rate (HR) during exercise may render a myocardial perfusion single photon emission computed tomography (SPECT) study non-diagnostic for ischemia detection. We sought to investigate the injection of atropine in patients who fail to achieve 80% of age-predicted HR during exercise performed for myocardial perfusion SPECT (MPS), defining its safety and efficacy to raise HR to adequate levels as well as its effect on MPS interpretation.Between January 2002 and December 2004, we studied 3,150 consecutive patients (2,253 men and 897 women, mean age 55 +/- 6 years) who were referred to a single office-based nuclear cardiology laboratory for MPS using …

AtropineMalemedicine.medical_specialtyIschemiaMyocardial IschemiaBlood PressureSingle-photon emission computed tomographySeverity of Illness IndexMetabolic equivalentCholinergic AntagonistsOrganophosphorus CompoundsHeart RateInternal medicineSpect imagingCoronary CirculationHeart rateMedicineHumansRadiology Nuclear Medicine and imagingTomography Emission-Computed Single-Photonexercise testingmedicine.diagnostic_testmaximal predicted heart ratebusiness.industrymyocardial perfusion SPECTArrhythmias CardiacOrganotechnetium CompoundsMiddle Agedmedicine.diseaseAtropineRate pressure productResearch DesignCardiologyExercise TestFeasibility StudiesFemaleRadiopharmaceuticalsCardiology and Cardiovascular MedicinebusinessPerfusionmedicine.drugThe international journal of cardiovascular imaging
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Spontaneous Cardiomyocyte Differentiation From Adipose Tissue Stroma Cells

2004

Cardiomyocyte regeneration is limited in adult life. Thus, the identification of a putative source of cardiomyocyte progenitors is of great interest to provide a usable model in vitro and new perspective in regenerative therapy. As adipose tissues were recently demonstrated to contain pluripotent stem cells, the emergence of cardiomyocyte phenotype from adipose-derived cells was investigated. We demonstrated that rare beating cells with cardiomyocyte features could be identified after culture of adipose stroma cells without addition of 5-azacytidine. The cardiomyocyte phenotype was first identified by morphological observation, confirmed with expression of specific cardiac markers, immunocy…

AtropineMalemedicine.medical_specialtyStromal cellPhysiologyCellular differentiationHeart VentriclesCholinergic AgentsAdipose tissueAdipose tissueCardiomyocytes ; Adipose tissue ; Differentiation ; Stem cells ; Cell therapyStem cellsBiologyCell therapyCell therapyMiceAdrenergic Agents:CIENCIAS MÉDICAS ::Medicina interna [UNESCO]Internal medicinemedicineAnimalsMyocytes CardiacHeart AtriaProgenitor cellInduced pluripotent stem cellCells CulturedUNESCO::CIENCIAS MÉDICAS ::Medicina internaCardiomyocytesRegeneration (biology)Multipotent Stem CellsIsoproterenolCell Differentiation:CIENCIAS MÉDICAS [UNESCO]Myocardial ContractionPropranololCell biologyClone CellsMice Inbred C57BLEndocrinologyPhenotypeAdipose TissueDifferentiationUNESCO::CIENCIAS MÉDICASRNACarbacholStem cellStromal CellsCardiology and Cardiovascular MedicineMyoblasts Cardiac
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Subtypes of muscarinic receptor on cholinergic nerves and atrial cells of chicken and guinea-pig hearts

1988

1. Electrically driven chicken and guinea-pig atria were used to investigate the negative inotropic effects of the muscarinic agonists methacholine and acetylcholine (ACh). The release of ACh from isolated hearts into the perfusate in response to (preganglionic) vagal or (pre- and postganglionic) field stimulation was bioassayed on the guinea-pig ileum or determined by labelling with [3H]-choline. 2. Concentration-response curves for the negative inotropic effect of methacholine were shifted to the right by pirenzepine in various concentrations (0.03 to 10 mumol l-1). The pA2 values were 7.76 in chicken atria and 6.53 in guinea-pig atria. Pirenzepine and atropine antagonized the negative in…

Atropinemedicine.medical_specialtyGuinea PigsTubocurarineStimulationIn Vitro TechniquesBiologyNeuroeffector junctionParasympathetic Nervous SystemInternal medicineMuscarinic acetylcholine receptormedicineAnimalsMethacholine CompoundsPharmacologyHeartVagus NervePirenzepineMyocardial ContractionReceptors MuscarinicPirenzepineAcetylcholineElectric StimulationVagus nerveAtropineEndocrinologyMethacholineChickensAcetylcholineResearch Articlemedicine.drugBritish Journal of Pharmacology
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