Search results for "N-2"

showing 10 items of 1881 documents

MiR-146b-5p regulates IL-23 receptor complex expression in chronic lymphocytic leukemia cells

2022

Abstract Chronic lymphocytic leukemia (CLL) cells express the interleukin-23 receptor (IL-23R) chain, but the expression of the complementary IL-12Rβ1 chain requires cell stimulation via surface CD40 molecules (and not via the B-cell receptor [BCR]). This stimulation induces the expression of a heterodimeric functional IL-23R complex and the secretion of IL-23, initiating an autocrine loop that drives leukemic cell expansion. Based on the observation in 224 untreated Binet stage A patients that the cases with the lowest miR-146b-5p concentrations had the shortest time to first treatment (TTFT), we hypothesized that miR-146b-5p could negatively regulate IL-12Rβ1 side chain expression and clo…

MiceMicroRNAsCD40 LigandAnimalsReceptors Antigen B-CellChronic lymphocytic leukemia interleukin-23 receptor (IL-23R) MiR-146bSettore MED/05 - Patologia ClinicaRNA MessengerHematologySettore MED/08 - Anatomia PatologicaInterleukin-23Leukemia Lymphocytic Chronic B-CellBlood Advances
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Recombinant epidermolytic (exfoliative) toxin A of Staphylococcus aureus is not a superantigen

1992

The epidermolytic (exfoliative) toxins produced by Staphylococcus aureus cause epidermolysis and skin blistering. In addition, they have been implicated to belong to the group of T lymphocyte stimulating molecules known as "superantigens". Here we show that recombinant epidermolytic toxin A produced in S. aureus is not mitogenic for human and murine T lymphocytes. We discuss the possibility that minute contaminations of highly mitogenic exoproteins may cause the mitogenicity in several proteins that are reported to be superantigens.

Microbiology (medical)Staphylococcus aureusT-LymphocytesBlotting WesternImmunologyClostridium difficile toxin ABiologyLymphocyte Activationmedicine.disease_causeMonocytesMicrobiologylaw.inventionMicelawSuperantigenmedicineAnimalsHumansImmunology and AllergyCloning MolecularStaphylococcus aureus delta toxinCells CulturedAntigens BacterialMice Inbred BALB CToxinGeneral MedicineT lymphocyteRecombinant ProteinsExfoliatinsCytolysisStaphylococcus aureusRecombinant DNAInterleukin-2SpleenMedical Microbiology and Immunology
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CCDC 1004248: Experimental Crystal Structure Determination

2014

Related Article: Murat Kucukdisli, Till Opatz|2014|Eur.J.Org.Chem.|2014|5836|doi:10.1002/ejoc.201402618

N-(368-trimethylindolizin-2-yl)acetamideSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 219569: Experimental Crystal Structure Determination

2005

Related Article: A.Valkonen, M.Lahtinen, E.Virtanen, S.Kaikkonen, E.Kolehmainen|2004|Biosens.Bioelectron.|20|1233|doi:10.1016/j.bios.2004.06.029

N-(3-Hydroxypropyl)-3alpha12alpha-dihydroxy-5beta-cholan-24-amideSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 647953: Experimental Crystal Structure Determination

2017

Related Article: A.Valkonen, E.Kolehmainen, M.Lahtinen, E.Sievanen, V.Noponen, M.Tolonen, R.Kauppinen|2007|Molecules|12|2161|doi:10.3390/12092161

N-(3-hydroxypropyl) 3alpha12alpha-dihydroxy-5beta-cholan-24-amide monohydrateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 957920: Experimental Crystal Structure Determination

2013

Related Article: Borys Ośmiałowski, Erkki Kolehmainen, Krzysztof Ejsmont, Satu Ikonen, Arto Valkonen, Kari Rissanen, Nonappa|2013|J.Mol.Struct.|1054|157|doi:10.1016/j.molstruc.2013.09.047

N-(6-Methylpyridin-2-yl)adamantane-1-carboxamide benzoic acidSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 854392: Experimental Crystal Structure Determination

2012

Related Article: B.Os'mialowski, E.Kolehmainen, R.Dobosz, R.Gawinecki, R.Kauppinen, A.Valkonen, J.Koivukorpi, K.Rissanen|2010|J.Phys.Chem.A|114|10421|doi:10.1021/jp1063116

N-(Pyridin-2-yl)adamantane-1-carboxamideSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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Accurate Spectroscopic Constants of Nitrogen Determined from Stimulated Raman Spectra of the Fundamental and 1st Hot Bands

1990

0377-0486; Nitrogen specta of the Q-branch of the fundamental and the first hot bands were recorded with a high-resolution stimulated Raman spectrometer at atmospheric pressure and ca. 1300 K. The absolute frequencies of the Raman lines were measured with high accuracy, leading to a refinement of spectroscopic constants. A temperature estimation was also performed from the Raman intensities.

N-14(2)Q-BRANCHN-2
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CCDC 1982669: Experimental Crystal Structure Determination

2023

Related Article: Antonin Jaillet, Christophe Darcel, Jérôme Bayardon, Adrien Schlachter, Christine Salomon, Yoann Rousselin, Pierre Harvey, Sylvain Jugé|2020|J.Org.Chem.|85|14391|doi:10.1021/acs.joc.0c00536

N-Methyl((2-hydroxy-1-methyl-2-phenyl)ethyl)amino-(11'-binaphthalen-2-yl)(phenyl)phosphineboraneSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1868988: Experimental Crystal Structure Determination

2019

Related Article: Evgeny Bulatov, Matti Haukka|2019|Dalton Trans.|48|3369|doi:10.1039/C8DT03912G

N-[(2-iodophenyl)methyl]-N-(pyridin-2-yl)pyridin-2-amineSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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