Recombinant epidermolytic (exfoliative) toxin A of Staphylococcus aureus is not a superantigen

6533b871fe1ef96bd12d25ab

RESEARCH PRODUCT

Recombinant epidermolytic (exfoliative) toxin A of Staphylococcus aureus is not a superantigen

Bernhard Fleischer C. J. Bailey

subject

Microbiology (medical)Staphylococcus aureus T-Lymphocytes Blotting Western Immunology Clostridium difficile toxin A Biology Lymphocyte Activation medicine.disease_cause Monocytes Microbiology law.invention Mice law Superantigen medicine Animals Humans Immunology and Allergy Cloning Molecular Staphylococcus aureus delta toxin Cells Cultured Antigens Bacterial Mice Inbred BALB C Toxin General Medicine T lymphocyte Recombinant Proteins Exfoliatins Cytolysis Staphylococcus aureus Recombinant DNA Interleukin-2 Spleen

description

The epidermolytic (exfoliative) toxins produced by Staphylococcus aureus cause epidermolysis and skin blistering. In addition, they have been implicated to belong to the group of T lymphocyte stimulating molecules known as "superantigens". Here we show that recombinant epidermolytic toxin A produced in S. aureus is not mitogenic for human and murine T lymphocytes. We discuss the possibility that minute contaminations of highly mitogenic exoproteins may cause the mitogenicity in several proteins that are reported to be superantigens.

year	journal	country	edition	language
1992-02-01	Medical Microbiology and Immunology

https://doi.org/10.1007/bf00191548

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