0000000001015331

AUTHOR

C. J. Bailey

showing 2 related works from this author

40(th) EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004

2004

0303 health sciencesmedicine.medical_specialtybusiness.industryEASDEndocrinology Diabetes and MetabolismHuman physiologymedicine.disease03 medical and health sciences0302 clinical medicineDiabetes mellitusFamily medicineInternal MedicineMedicinebusiness030217 neurology & neurosurgery030304 developmental biology
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Recombinant epidermolytic (exfoliative) toxin A of Staphylococcus aureus is not a superantigen

1992

The epidermolytic (exfoliative) toxins produced by Staphylococcus aureus cause epidermolysis and skin blistering. In addition, they have been implicated to belong to the group of T lymphocyte stimulating molecules known as "superantigens". Here we show that recombinant epidermolytic toxin A produced in S. aureus is not mitogenic for human and murine T lymphocytes. We discuss the possibility that minute contaminations of highly mitogenic exoproteins may cause the mitogenicity in several proteins that are reported to be superantigens.

Microbiology (medical)Staphylococcus aureusT-LymphocytesBlotting WesternImmunologyClostridium difficile toxin ABiologyLymphocyte Activationmedicine.disease_causeMonocytesMicrobiologylaw.inventionMicelawSuperantigenmedicineAnimalsHumansImmunology and AllergyCloning MolecularStaphylococcus aureus delta toxinCells CulturedAntigens BacterialMice Inbred BALB CToxinGeneral MedicineT lymphocyteRecombinant ProteinsExfoliatinsCytolysisStaphylococcus aureusRecombinant DNAInterleukin-2SpleenMedical Microbiology and Immunology
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