Search results for "N-acetyl-aspartate"
showing 2 items of 2 documents
PRELIMINARY-OBSERVATIONS OF METABOLIC CHARACTERIZATION OF BILATERAL TEMPORAL EPILEPTIC FOCUS, USING PROTON MAGNETIC-RESONANCE SPECTROSCOPY - 3 CASES
1994
International audience; Abstract: The authors report the case of 3 patients with bilateral temporal lobe epilepsy demonstrated by EEG and sphenoidal electrodes. Two out of the 3 patients presented with childhood febrile convulsions. Their neurological and mental examination was normal. EEG showed spikes within the anterior part of the 2 temporal lobes. CT scan and MRI showed no atrophic lesion within the 2 temporal lobes. Proton magnetic resonance spectroscopy, performed within a cube of 8 cube-centimetres localized in the anterior part of the 2 temporal lobes showed a significant decrease of N-acetyl-aspartate in the 2 temporal lobes of the 3 cases, compared with controls matched with age,…
Reduced brain N-acetyl-aspartate in frontal lobes suggests neuronal loss in patients with amyotrophic lateral sclerosis
1996
International audience; Abstract: We performed proton magnetic resonance spectroscopy (IH-MRS) in three patients with amyotrophic lateral sclerosis (ALS) to evaluate the distribution and extent of cortical neuronal damage as demonstrated by decreased N-acetyl-aspartate (NAA) levels. We examined primary motor (precentral gyrus) and parietal neocortical (superior parietal gyrus) regions. ALS was defined with lower and upper motor neuron signs. Compared with matched healthy controls, ALS patients had a significant decrease in NAA levels in the primary motor cortex (p<0.001) compared with parietal regions and homologous regions in healthy controls. Two clinical applications can be extracted: fi…