Search results for "NAD"
showing 10 items of 2033 documents
Prognostic heterogeneity of adult B-cell precursor acute lymphoblastic leukaemia patients with t(1;19)(q23;p13)/TCF3-PBX1 treated with measurable res…
2021
Programa para el Tratamiento de Hemopatias Malignas (PETHEMA) Group (Spanish Society of Hematology, SEHH).
Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (Neo…
2011
Summary Background Studies with pertuzumab, a novel anti-HER2 antibody, show improved efficacy when combined with the established HER2-directed antibody trastuzumab in breast cancer therapy. We investigated the combination of pertuzumab or trastuzumab, or both, with docetaxel and the combination of pertuzumab and trastuzumab without chemotherapy in the neoadjuvant setting. Methods In this multicentre, open-label, phase 2 study, treatment-naive women with HER2-positive breast cancer were randomly assigned (1:1:1:1) centrally and stratified by operable, locally advanced, and inflammatory breast cancer, and by hormone receptor expression to receive four neoadjuvant cycles of: trastuzumab (8 mg…
Controversial roles of methylenetetrahydrofolate reductase polymorphisms and folate in breast cancer disease
2014
Abstract Breast cancer (BC) represents a highly heterogeneous tumour at both the clinical and molecular levels. Single-nucleotide polymorphisms (SNPs) of the folate-metabolising enzyme methylenetetrahydrofolate-reductase (MTHFR) may modify the association between folate intake and BC and influence plasma folate concentration. The role of folate in BC is equivocal, association studies between the common MTHFR SNPs C677T and A1298C and BC risk are controversial. In this study, I have reviewed observed associations between folate intake, as well as its blood levels, and BC. The purpose of this review is to analyse the role of folate and the two SNPs associated with reduced enzyme activity in B…
PKP-020 Impact of nadph oxidase functional polymorphisms in acute myeloid leukaemia induction chemotherapy
2016
Background NADPH oxidase, a key mediator of oxidative cardiac damage and remodelling, modulates anthracycline clinical cardiotoxicity. Purpose Single nucleotide polymorphisms (SNPs) of NADPH oxidase genes could lead to interindividual differences in treatment outcome in acute myeloid leukaemia (AML) patients. Material and methods The main three NADPH oxidase polymorphisms (CYBA:rs4673, NCF4:rs1883112 and RAC2:rs13058338) were evaluated in 225 adult patients at the initial diagnosis of AML using a mass spectrometry based multiplex genotyping assay (Sequenom). All patients received induction chemotherapy consisting of idarubicin plus cytarabine (PETHEMA 99, 2007 and 2010 trials). The efficacy…
Factors related to early castration resistance in metastatic prostate cancer. Results from the National Prostate Cancer Registry in Spain
2019
Abstract Introduction The objective of the study was to determine the factors independently related with the development of castration resistance (CR) in prostate cancer (PC) in the medium term. Material and methods 155 patients diagnosed with metastatic PC with a follow-up of up to 39 months. Data taken from the National PC Registry. The evaluated variables were age, PSA, nadir PSA, Gleason, perineural invasion, TNM stages, and ADT type (intermittent / continuous). Results Mean follow-up 26,2 ± 13,4 months. 47.1% developed early CR, with mean time until onset of 12,2 ± 8,7 months. Univariate analysis: the mean PSA was correlated with CR (290 ± 905,1 ng/mL in non CR, 519,1 ± 1437,2 ng/mL in…
Technical and economical assessment of distributed electrochemical storages for load shifting applications: An Italian case study
2016
Time-of-use (TOU) energy cost management involves the use of energy storage systems (ESSs) by customers to reduce their electricity bills. The ESS is charged during off-peak time periods, when electricity energy prices are low, and discharged during times when on-peak energy prices are applied. This article addresses the question whether it is economically viable to install medium-scale distributed ESSs designed to lower the electricity cost for a customer-side application, assuming flexible electricity tariffs. The technical/economical evaluation is carried out referring to lithium-ion (Li-ion), sodium sulfur (NaS) and vanadium redox battery (VRB) technologies, performing a parametric anal…
The transcriptional activator rfiA is quorum-sensing regulated by cotranscription with the luxI homolog pcol and is essential for plant virulence in …
2009
The gram-negative phytopathogen Pseudomonas corrugata has an acyl-homoserine lactone (AHL) quorum-sensing (QS) system called PcoI/PcoR that is involved in virulence on tomato. This work identifies, downstream of pcol, a gene designated rfiA, which we demonstrate is directly linked to QS by cotranscription with pcol. The deduced RfiA protein contains a DNA-binding domain characteristic of the LuxR family but lacks the autoinducer-binding terminus characteristic of the QS LuxR-family proteins. We also identified, downstream of rfiA, an operon designated pcoABC, encoding for the three components of a tripartite resistance nodulation-cell-division (RND) transporter system. The expression of pco…
Remote photoplethysmography for skin perfusion monitoring using narrowband illumination
2019
The purpose of this study was to determine potential of remote photoplethysmography for skin perfusion monitoring, using 540 nm narrowband and 530 nm broadband illuminations. The alterations of cutaneous circulation were produced by topical skin heating protocol. The setup comprises of 530 nm LED light source and two identical cameras operated simultaneously: one equipped with narrowband optical filter (CWL=540nm), and another without filter. Results demonstrate the typical heating test response curve- comprising first peak, nadir and plato phase, which were significantly different in narrowband and broadband illumination. It was concluded that selection of optimal light source parameters i…
Políticas sobre el software libre en el contexto educativo español. El caso de dos escuelas de primaria
2010
El artículo analiza las disfunciones que suscita en las prácticas escolares la aplicación del software libre. Hecho que se produce tanto por la peculiaridad de esta tecnología como por las políticas que promueven los proyectos institucionales de difusión del SL. ¿Cómo tales políticas condicionan las prácticas de enseñanza? Desde el enfoque de los estudios de Ciencia, Tecnología y Sociedad, tratamos de responder al interrogante estudiando varios centros de primaria con técnicas de corte cualitativo. Concluimos que las políticas enfatizan la difusión del SL, pero son remisas en estrategias de acompañamiento para asegurar el éxito de su aplicación.
Is Digital Literacy Improving Science Education?
2015
Mass media, and especially digital media, have become an important tool of literacy and have increased their use in classrooms for educational purposes. This is of great interest in scientific literacy and Brossard and Shanahan (2006) developed an instrument to evaluate the understanding of scientific terms and basic science concepts. In this quantitative study we analyse the relationship between Spanish digital mass media and scientific literacy in pre-service pri- mary teachers (N = 189). Results showed that these university students have a term knowledge level lower than the one found by Brossard and Shanahan in the USA. On the other hand, conceptual knowledge was not correlated at all to t…