Search results for "NAK"
showing 10 items of 469 documents
Näin helpolla näkyvyyttä saisi
2014
Kooste JY:n vuoden 2013 A1-artikkelien rinnakkaistallennusluvista. Avoin tallentaminen on paljon luultua luvallisempaa. nonPeerReviewed
Open Access -trendit ja rinnakkaistallentaminen Suomessa 2015
2016
Esitelmä ATT-hankkeen strategiaryhmässä 28.4.2016
Polarization modulation instability in a Manakov fiber system
2015
International audience; The Manakov model is the simplest multicomponent model of nonlinear wave theory: It describes elementary stable soliton propagation and multisoliton solutions, and it applies to nonlinear optics, hydrodynamics, and Bose-Einstein condensates. It is also of fundamental interest as an asymptotic model in the context of the widely used wavelength-division-multiplexed optical fiber transmission systems. However, although its physical relevance was confirmed by the experimental observation of Manakov (vector) solitons in a planar waveguide in 1996, there have in fact been no quantitative experiments confirming its validity for nonlinear dynamics other than soliton formatio…
Selective and sensitive colorimetric detection of the neurotransmitter serotonin based on the aggregation of bifunctionalised gold nanoparticles
2018
[EN] We report a simple, sensitive and selective method for the colorimetric detection of serotonin (5-HT) in aqueous media using bifunctionalized gold nanoparticles (AuNPs). The probe (1) consisted of AuNPs functionalised with dithiobis(succinimidylpropionate) (DSP) and N-acetyl-l-cysteine (NALC). DSP was chosen to react with the amino group of 5-HT, whereas NALC was chosen to bind the hydroxyl group in 5-HT through hydrogen bonding and electrostatic interactions. A double interaction between nanoparticles and the hydroxyl and the amino group of serotonin led to interparticle-crosslinking aggregation. This, resulted in a colour change from red to blue that can be observed by the naked eye.…
Colorimetric detection of normetanephrine, a pheochromocytoma biomarker, using bifunctionalised gold nanoparticles.
2019
[EN] A simple and effective colorimetric method for the detection of normetanephrine (NMN), an O-methylated metabolite of norepinephrine, using functionalised gold nanoparticles is described. This metabolite is an important biomarker in the diagnosis of adrenal tumours such as pheocromocytoma or paraganglioma. The colorimetric probe consists of spherical gold nanoparticles (AuNPs) functionalised with two different ligands, which specifically recognize different functional groups in normetanephrine. Thus, a benzaldehyde-terminated ligand was used for the recognition of the amino alcohol moiety in NMN, by forming the corresponding oxazolidine. On the other hand, N-acetyl-cysteine was chosen f…
Effects of triplet Higgs bosons in long baseline neutrino experiments
2018
The triplet scalars $(\Delta=\Delta^{++},\Delta^{+},\Delta^{0})$, utilized in the so-called Type-II seesaw model to explain the lightness of neutrinos, would generate nonstandard interactions (NSI) for neutrino propagating in matter. We investigate the prospects to probe these interactions in long baseline neutrino oscillation experiments. We analyze the upper bounds that the proposed DUNE experiment might set on the nonstandard parameters and numerically derive upper bounds, as function of the lightest neutrino mass, on the ratio the mass $M_\Delta$ of the triplet scalars and strength $|\lambda_\phi|$ of the coupling $\phi\phi\Delta$ of the triplet $\Delta$ and conventional Higgs doublet $…
Quando il dottor Zhivago si imbatté in Stanislao Moulinsky: Fatalità e forme narrative.
2007
Il confronto tra romanzi diversi, da Fantomas a Guerra e pace e al Dottor Zivago, è finalizzato a mettere in discussione le definizioni correnti di letteratura di massa e la teoria che vuole l'intera produzione realsocialista appartenere a questa categoria.
"Laiks ir noslēpumaina substance ... " (Z. Skujiņš)
2017
Rakstā sniegts ieskats par Muzeju nakts pasākumu norisi Latvijas Universitātes Bibliotēkā 2017. gada 22. maijā. Pasākumā dalībnieki varēja lasīt senus tekstus latviešu valodā, kas izdoti gotiskā rakstā ar raksturīgiem smailiem, stūrainiem burtiem, kā arī atrast grāmatas bibliotēkas plauktos, izmantojot bibliotēkas lietotāju elektroniski izveidotos pasūtījumus. Apmeklētājiem tika piedāvātas arī vairākas izstādes. Viena no izstādēm Dr. Mārtiņa Lutera darbu sējumi, kas tapuši 18. gadsimtā, tiem varēja pieskarties un tos pārlapot, izmantojot kokvilnas cimdus. Viesiem, kuriem interesēja fotogrāfijās iemūžināts laiks, bija iespēja vērot LU Bibliotēkas attīstību vēsturiskās fotogrāfijās – gan senā…
Naked DNA delivery to whole pig cardiac tissue by coronary sinus retrograde injection employing non-invasive catheterization.
2010
Background Hydrodynamic injection has demonstrated to be very efficient in the liver of small animals, although this procedure must be translated to the clinical practice in a milder but no less efficient way. The present study evaluates the capacity of non-invasive interventional catheterization as a procedure for naked DNA delivery to the heart in large animals. Methods Two catheters were placed in the coronary sinus: one of them to block blood circulation and the other to retrogradely inject 50 ml of a saline solution of DNA (20 µg/ml) containing the enhanced green fluorescent protein (EGFP) gene, at a flow rate of 5 ml/s. Results The results obtained show that EGFP protein, identified b…
Pig liver gene therapy by noninvasive interventionist catheterism
2006
The efficacy of noninvasive interventionist catheterism in large animals as an alternative to the hydrodynamic procedure, described for small animals, is evaluated. Basically, gene transfer is performed by implantation and fixation of a balloon catheter within the suprahepatic vein of anesthetized pigs, through the femoral vein. The catheter tip is identified by fluoroscopy, injecting a contrast solution that marks large or small hepatic territories. Animals were injected with a 100 ml pTG7101 plasmid solution (40 microg/ml), which contains the human alpha-1 antitrypsin gene, perfused at a rate of 7.5 ml/s and efficacy and toxicity of the procedure were evaluated. The results show: (i) the …