Search results for "NAK"

Anakinra drug retention rate and predictive factors of drug survival in systemic juvenile idiopathic arthritis and adult onset Still’s disease.

2019

Introduction: Only a few studies have reported the long-term efficacy of interleukin (IL)-1 inhibition in systemic juvenile idiopathic arthritis (sJIA) and adult onset Still’s disease (AOSD). We herein describe Anakinra (ANA) effectiveness expressed in terms of drug retention rate (DRR) and evaluate predictive factors of drug survival in sJIA and ASOD patients. Objectives: Examine the overall DRR of ANA in sJIA and AOSD patients. Explore the influence of biologic line of treatment, and the concomitant use of disease modifying anti-rheumatic drugs (cDMARDs) on DRR in the whole sample and stratified according to the disease thereafter; find eventual predictive factors associated with events l…

VALUTAZIONE DELLA CRESCITA IN PAZIENTI CON ARTRITE IDIOPATICA GIOVANILE SISTEMICA

2021

MIS-C in un paziente con AIG sistemica e mutazione di NLRP-3 in terapia con anakinra

2021

IL-1 BLOCKADE IN PAEDIATRIC RECURRENT PERICARDITIS: A MULTICENTRIC RETROSPECTIVE STUDY OF THE ITALIAN COHORT

2019

Introduction: Acute pericarditis is an inflammatory condition causing the occurrence of pericardial effusion. In a third of patients, the disease is recurrent. First line treatment of idiopathic pericarditis consists in non-steroidal anti-inflammatory drugs (NSAIDs) and colchicine; glucocorticoids represent the second line treatment in resistant or intolerant cases. A recent clinical trial has enlightened the effectiveness of anakinra in adults and paediatric patients with colchicine-resistant recurrent pericarditis. Objectives: To describe the clinical characteristics and response to treatment in a cohort of paediatric patients with recurrent pericarditis treated with IL inhibitors. Method…

Canakinumab in systemic juvenile idiopathic arthritis: clinical inactive disease rate and safety in italian patients

2019

Introduction: Systemic juvenile idiopathic arthritis (sJIA) is a polygenic autoinflammatory disease. The pathophysiology is still unclear, it is now well known that innate immune mechanisms play a central role with overproduction of inflammatory cytokines. The increased knowledge on the role of these cytokines has provided a change in the natural history of the disease with the introduction of the targeted treatments. Remarkable results has been observed with canakinumab, an anti-interleukin-1β monoclonal antibody, in two clinical trials but little information are available in real life. Objectives: To evaluate clinical inactive disease rate and safety of canakinumab in Italian patients wit…

Tasso di persistenza in terapia di anakinra e canakinumab nelle malattie autoinfiammatorie monogeniche: studio osservazionale dal registro internazio…

2021

Kalmbergin kartasto R VI : List 7

1855

Feeding habits of the Short-toed Eagle Circaetus gallicus during the breeding period in Central Italy

2022

Short-toed Eagle Circaetus gallicus is the only snake eagle that nests in the Palearctic. Its diet has been studied in several European countries and it is essentially based on reptiles. The aims of this work were to characterise the feeding habits of Short-toed Eagle breeding in the Tolfa Mountains (Central Italy) including a comparison of the diet with that of other populations. Moreover, we assessed changes in the diet of the former population using published data collected more than 35 years ago. We monitored five nests and three roosts between 2020 and 2021. Using camera traps and the collection and analysis of feeding remains, a total of 247 prey items were identified. The diet of the…

Empowered by stigma? Pioneer organic farmers' stigma management strategies

2019

Abstract Pioneers of organic farming often faced social challenges as their innovative ideas on agriculture not only encountered opposition in the conventional farming community, but led to stigmatization of organic farmers as social deviants. In this study, we examine what kind of stigma management strategies pioneer organic farmers engage with in order to cultivate an alternative positive image of themselves. Our research is based on the interviews with 14 pioneer organic farmers. Based on a qualitative analysis of the interviews, we provide a model of those strategies that the creation from a stigmatized to valued identity requires. Our study increases the understanding of the institutio…

CCDC 845599: Experimental Crystal Structure Determination

2012

Related Article: J.-F.Ayme, J.E.Beves, D.A.Leigh, R.T.McBurney, K.Rissanen, D.Schultz|2012|J.Am.Chem.Soc.|134|9488|doi:10.1021/ja303355v