Search results for "NAS"
showing 10 items of 12064 documents
Pirkstiņrotaļas un rotaļas ar priekšmetiem 3- 4 gadus vecu bērnu griešanas prasmes sekmēšanai
2019
Kvalifikācijas darba tēma ir, “Pirkstiņrotaļas un rotaļas ar priekšmetiem 3-4 gadus vecu bērnu griešanas prasmes sekmēšanai”. Darba mērķis ir teorētiski analizēt un praktiski pētīt, kā pirkstiņrotaļu un rotaļu ar priekšmetiem pielietošana sekmē 3-4 gadus vecu bērnu griešanas prasmes. Mērķa sasniegšanai tika izvirzīti vairāki uzdevumi: 1. Analizēt pedagogu un psihologu atziņas par 3-4 gadus vecu bērnu attīstību un raksturot griešanas prasmes. 2.Analizēt pedagogu atziņas par rotaļu, pirkstiņrotaļu pētījuma kontekstā. 3.Veikt pētījumu par griešanas prasmju sekmēšanu rotaļā. Darba pirmajā daļā teorētiski tiek analizēta pedagogu un psihologu atziņas par bērna attīstības īpatnībām vidējā pirmskol…
Circular RNA in Exosomes
2018
Circular RNAs (circRNAs) are a novel family of non-coding endogenous RNAs discovered in all eukaryotic cells and generated through a particular mechanism of alternative splicing called “back-splicing”. These molecules show multiple functions, by acting as modulators of gene and miRNA expression, and may have a role in several biological processes, such as cell proliferation and invasion with, tumour development and progression, and in several mechanisms underlying other diseases. Their presence has been shown to be abundant in several body fluids such as blood and saliva. Based on their biogenesis mechanism, cir- cRNAs may be categorized into five classes: exonic circRNAs, intronic circRNAs…
Kopolimery olefin z alkenylosilseskwioksanami
2016
Artykuł stanowi przegląd literatury dotyczącej syntezy i charakterystyki materiałów hybrydowych uzyskanych na drodze kopolimeryzacji alkenylopodstawionych silseskwioksanów z olefinami. Przedstawiono przykłady wykorzystania m.in. procesów kopolimeryzacji koordynacyjnej do syntezy kopolimerów olefin i silseskwioksanów (POSS). Jednocześnie wskazano korzyści płynące z obecności POSS w strukturze polimeru, które przekładają się na jego zwiększoną odporność termiczną oraz parametry mechaniczne.
Re: Technique of internal mammary dissection using pectoralis major flap to prevent contour deformities
2009
Apdrošināšanas sistēmas komponenšu modernizācija
2022
Kvalifikācijas darba ietvaros tika veikta divu apdrošināšanas sistēmas komponentu modernizācija uz .Net Core standartu, saglabājot esošo funkcionalitāti. Izstrādātās komponentes nodrošina iespēju sistēmas administratoram apskatīt esošas sistēmas lietotājus, veidot jaunus lietotājus, pārvaldīt lietotajā grupas un lomas, ka arī sistēmas lietotajam apskatīt polises apdrošināšanas atlīdzības un tai pievienotus failus. Šī darba mērķis: • modernizēt esošas .Net framework sistēmas komponentus uz jaunu .Net Core standartu, dodot iespēju kontainerizēt šīs komponentes izvietošanai makoņpakalpojumā • pārrakstīt lapas no ASP.NET Web Forms uz ASP.NET Core MVC izmantojot Razor pages. • atvieglināt sistēm…
Heavy enzymes and the rational redesign of protein catalysts
2019
Abstract An unsolved mystery in biology concerns the link between enzyme catalysis and protein motions. Comparison between isotopically labelled “heavy” dihydrofolate reductases and their natural‐abundance counterparts has suggested that the coupling of protein motions to the chemistry of the catalysed reaction is minimised in the case of hydride transfer. In alcohol dehydrogenases, unnatural, bulky substrates that induce additional electrostatic rearrangements of the active site enhance coupled motions. This finding could provide a new route to engineering enzymes with altered substrate specificity, because amino acid residues responsible for dynamic coupling with a given substrate present…
Protonation of Tyrosine Kinase Inhibitor Lapatinib: A Theoretical and Experimental Study
2019
The protonation process of tyrosine kinase inhibitor lapatinib was studied by means of 1HNMR and UV/Vis spectroscopy joint with the theoretical calculations at DFT and semi-empirical levels. DFT/M06-2X geometries were used to describe and compare the different cationic forms of lapatinib, while ZINDO/S-CI method performed on those geometries allowed for the interpretation of experimental UV/Vis spectra of lapatinib at various pH. We found that at low pH two different dicationic forms (N2N1 and N1N3) of lapatinib were present in ethanol and DMSO-d6 solutions. The first protonation, however, occurred on the aliphatic N1 in DMSO-d6, while in ethanol solutions most probably the quinazoline nitr…
Effect of different concentrations of specific inhibitor of matrix metalloproteinases on the shear bond strength of self-adhesive resin cements to de…
2017
Background Considering the probability of chemical and enzymatic reactions between matrix metalloproteinases (MMPs) in the dentin structure and their specific inhibitors, the aim of the present study was to evaluate the effect of different concentrations of specific inhibitor of MMPs (galardin) on the shear bond strength of self-adhesive resin cements to dentin. Material and Methods Forty-eight sound human premolars were mounted in self-cured acrylic resin after removal of the enamel on the buccal and lingual surfaces. The dentin surfaces achieved were polished and prepared with 600-grit silicon carbide paper. The samples were divided into 3 groups (n=16) based on the concentration of galar…
Downscaling of American National Aeronautics and Space Administration (NASA) daily air temperature in Sicily, Italy, and effects on crop reference ev…
2018
Abstract Air temperature (Ta) is one of the key factors in agro-hydrological studies including estimation of crop reference evapotranspiration (ET0), which is crucial for irrigation water management and sustainability of agro-ecosystem productivity. Because direct measurements of ET0 are difficult, expensive and time consuming, the use of physically based or empirical approaches linked to meteorological information is often preferred. The Prediction of Worldwide Energy Resource project developed by the American National Aeronautics and Space Administration (POWER-NASA) provides daily meteorological information on a 1° latitude by 1° longitude grid. Despite the poor spatial resolution charac…
Magma extrusion during the Ubinas 2013-2014 eruptive crisis based on satellite thermal imaging (MIROVA) and ground-based monitoring
2015
International audience; After 3 years of mild gases emissions, the Ubinas volcano entered in a new eruptive phase on September 2nd, 2013. The MIROVA system (a space-based volcanic hot-spot detection system), allowed us to detect in near real time the thermal emissions associated with the eruption and provided early evidence of magma extrusion within the deep summit crater. By combining IR data with plume height, sulfur emissions, hot spring temperatures and seismic activity, we interpret the thermal output detected over Ubinas in terms of extrusion rates associated to the eruption. We suggest that the 2013–2014 eruptive crisis can be subdivided into three main phases: (i) shallow magma intr…