Search results for "NBS"
showing 10 items of 43 documents
The effects of 8-weeks Mindfulness-Based Stress Reduction program on cognitive control: an EEG study
2019
Objectives: Mindfulness practice can enhance different aspects of attentional functions, such as the ability to sustain the attentional focus over time. However, it is still unclear whether this practice might indeed impact higher cognitive functions, such as control mechanisms that allow the appropriate and flexible allocation of attentional resources. In this longitudinal study, changes associated with a mindfulness-based stress reduction (MBSR) program were investigated, with a focus on proactive and reactive cognitive control mechanisms, namely, the ability to maintain task-relevant information and to prepare in advance the response, and the ability to promptly adjust overlearned behavi…
Dietary fiber intake and mortality in a Mediterranean population: the “Seguimiento Universidad de Navarra” (SUN) project
2018
Purpose To prospectively assess the association of dietary fiber intake (from different dietary sources) with all-cause mor-tality in a Mediterranean cohort. Methods We assessed 19,703 participants of the SUN (Seguimiento Universidad de Navarra) cohort (mean follow-up: 10.1 years). A validated 136-item FFQ was administered at baseline. We used Cox proportional hazards models adjusted for multiple socio-demographic, anthropometric, lifestyle factors, and prevalent conditions at baseline. Results We observed 323 deaths during 198,341 person-years of follow-up. A significantly inverse linear trend in Cox models was observed for the association of total dietary fiber intake and all-cause mortal…
Nrg1 haploinsufficiency alters inhibitory cortical circuits
2021
Neuregulin 1 (NRG1) and its receptor ERBB4 are schizophrenia (SZ) risk genes that control the development of both excitatory and inhibitory cortical circuits. Most studies focused on the characterization ErbB4 deficient mice. However, ErbB4 deletion concurrently perturbs the signaling of Nrg1 and Neuregulin 3 (Nrg3), another ligand expressed in the cortex. In addition, NRG1 polymorphisms linked to SZ locate mainly in non-coding regions and they may partially reduce Nrg1 expression. Here, to study the relevance of Nrg1 partial loss-of-function in cortical circuits we characterized a recently developed haploinsufficient mouse model of Nrg1 (Nrg1tm1Lex). These mice display SZ-like behavioral d…
Detailed characterization of human Mycobacterium tuberculosis specific HLA-E restricted CD8+TÂ cells
2018
HLA-E presented antigens are interesting targets for vaccination given HLA-Esâ essentially monomorphic nature. We have shown previously that Mycobacterium tuberculosis (Mtb) peptides are presented by HLA-E to CD8+effector TÂ cells, but the precise phenotype and functional capacity of these cells remains poorly characterized. We have developed and utilized in this study a new protocol combining HLA-E tetramer with intracellular staining for cytokines, transcription factors and cytotoxic molecules to characterize these cells in depth. We confirm in this study the significantly increased ex vivo frequency of Mtb-peptide/HLA-E-TM+CD8+TÂ cells in the circulation of patients with active tubercu…
Past, ongoing, and future debate on the interplay between internationalization and digitalization
2020
AbstractThe interplay between internationalization and digitalization (IDI) is a relatively young research domain that is finding its way into numerous academic journals, which motivates us to systematically portray the proceedings and evolutions of this interplay over time, analyze its methodological and theoretical background and, more importantly, provide insights to guide future research on these phenomena. Combining qualitative and quantitative approaches, we analyze 68 peer-reviewed international business and management papers to explore the structure of knowledge production and identify the emerging trends. Our research reveals four key stages of the debate: (a) how IDI influencesint…
Efficacy of budesonide-loaded mesoporous silica microparticles capped with a bulky azo derivative in rats with TNBS-induced colitis.
2019
Abstract A colon targeted drug delivery system for inflammatory bowel diseases (IBD), consisting in budesonide loaded mesoporous silica microparticles functionalized with a selective azo-molecular gate (M-Bud), has been evaluated for in vivo efficacy. Experimental colitis in male Wistar rats was induced by rectal instillation of 2,4,6-trinitrobenzenesulfonic acid (TNBS). M-Bud was orally administered to the rats as a suspension in water. Colon/body weight ratio, clinical activity score, and histological evaluation were used as inflammatory indices to measure the performance of the microparticles. The formulation was compared with a suspension prepared from the commercial drug Entocord®. Sta…
Determinants affecting consumers' attention to fish eco-labels in purchase decisions: a cross-country study
2022
PurposeThe purpose of this study was to investigate the role of consumer altruism and other socio-cultural factors in predicting how much attention consumers pay to seafood eco-labels.Design/methodology/approachThe empirical investigation was carried out by administering an online questionnaire to a sample of Italian and Spanish people from December 2019 to April 2020. After carrying out the principal component analysis procedure, the work made use of an ordinal logistic regression.FindingsBoth Italian and Spanish consumers with an altruistic attitude, who feel that food produced in a sustainable way can protect the environment and workers, appear more likely to take an eco-label into accou…
Sub specie æternitatis: the role of the ruin and the ancient in the process of architectural renewal between metamorphosis and resurgence
2022
Composing new works of architecture inspired by vestiges from antiquity or archaeology. The reflections and the case study which will be proposed, pertaining to a recent design experiment for the archaeological area and Antiquarium of Tyndaris, are dedicated to this theme. Over and above any charm exerted by such places, by landscapes in which the ruins appear identical in substance and which sometimes manifest themselves as “sub specie æternitatis”, there are reasons linked to the very profession of architect and to the gashes in the crucible of controversies around the role of history in its contentious relationship with architectural design. That apart, the aporias revealed by Michel Fou…
New records and observations to the Characean flora (Charales, Charophyceae) of Sicily (Italy)
2019
New records to the Characean flora of Sicily are presented. Five species (Chara baltica, C. conimbrigensis, C. oedophylla, Nitella gracilis, Tolypella salina) are new to Sicily, two of them being also new to Italy (Chara conimbrigensis, C. oedophylla). Two species are confirmed for Sicily (Chara aspera, Nitella opaca), three (Chara braunii, C. canescens, Nitella capillaris) are rare taxa. The Characean flora of Sicily, updated with these records, currently includes 25 species, distributed in four genera: Chara (13 species), Nitella (eight species), Tolypella (three species) and Lamprothamnium (one species).
Linearized Calderón problem and exponentially accurate quasimodes for analytic manifolds
2022
In this article we study the linearized anisotropic Calderon problem on a compact Riemannian manifold with boundary. This problem amounts to showing that products of pairs of harmonic functions of the manifold form a complete set. We assume that the manifold is transversally anisotropic and that the transversal manifold is real analytic and satisfies a geometric condition related to the geometry of pairs of intersecting geodesics. In this case, we solve the linearized anisotropic Calderon problem. The geometric condition does not involve the injectivity of the geodesic X-ray transform. Crucial ingredients in the proof of our result are the construction of Gaussian beam quasimodes on the tra…