Search results for "NCEP"
showing 10 items of 3866 documents
Neuro-endocrine networks controlling immune system in health and disease
2014
The nervous and immune systems have long been considered as compartments that perform separate and different functions. However, recent clinical, epidemiological, and experimental data have suggested that the pathogenesis of several immune-mediated disorders, such as multiple sclerosis (MS), might involve factors, hormones, and neural mediators that link the immune and nervous system. These molecules are members of the same superfamily, which allow the mutual and bi-directional neural–immune interaction. More recently, the discovery of leptin, one of the most abundant adipocyte-derived hormones that control food intake and metabolism, has suggested that nutritional/metabolic status, acting …
Immunological Markers for PML Prediction in MS Patients Treated with Natalizumab
2015
International audience; Natalizumab (NTZ), a monoclonal antibody recognizing the alpha4 integrin chain, has been approved for the treatment of active multiple sclerosis, but expose to the onset of a rare side effect, progressive multifocal leukoencephalopathy (PML). Estimating the individual risk of PML in NTZ-treated patients is a major challenge, and therapeutic strategies are mainly guided by the overall PML risk assessed by identified risk factors: JC virus (JCV) seropositivity, treatment duration (with peak incidence after 24 months), and the previous use of immunosuppressive therapies. Given that this stratification does not yet allow a precise individual prediction of PML, other pred…
La complejidad social de la discapacidad. Algunos ejemplos de la narración fílmica
2010
Abordar la discapacidad desde una perspectiva multidisciplinar, que recurre a la narración fílmica como método de análisis, puede ayudar a indicar la noción adecuada en referencia a esta realidad dentro de la complejidad terminológica y conceptual existente a nivel jurídico-social. Son muchas las denominaciones utilizadas, y éstas han ido variando en función de los cambios de paradigma en la materia. Se han distinguido tres modelos de tratamiento que, a su vez, han ido apareciendo en la narración fílmica: el tradicional, el médico y el social. Se enfatiza este último ya que entiende la discapacidad como el conjunto de desventajas que el individuo con deficiencias sufre cuando el entorno es…
En defensa de una concepción alternativa de la interpretación jurídica
2011
RESUMEN El presente trabajo tiene como objetivo analizar críticamente las concepciones de la interpretación jurídica – cognitiva, escéptica, e intermedia – que vienen copando la discusión en torno a esta cuestión en el ámbito de la Teoría del Derecho y presentar los rasgos básicos de una comprensión de la tarea interpretativa, en cierto sentido alternativa a las anteriores teorías estándar, que ofrece una mejor explicación de sus aspectos centrales ABSTRACT This work looks critically into three conceptions of legal interpretation - cognitive, skeptical, and intermediate- that come monopolizing the discussion on this issue in the field of Law Theory. This paper presents the basic features o…
La educación en casa o homeschooling: la STC de 2 de diciembre de 2010
2011
[EN] This article analyses raising conflicts between children ́ education ́s right and freedom of education belonging to parents and tutors, according to the complex article 27 of Spanish Constitution, especially after the recent sentence of Constitucional Court dated from 2nd December 2010, all of this in relation with the possiblility of giving basic education not through compulsory education but homeschooling.
Impacto de la implementación de un modelo ecoformativo a través de proyectos estratégicos : el caso de la Universidad Castro Carazo (Costa Rica)
2020
La Universidad Castro Carazo ha adoptado un modelo educativo de ecoformación desde el año 2016. Para esto, ha sido necesaria la incorporación de buenas prácticas y estrategias de innovación pedagógica y curricular, como parte integral de sus procesos educativos y administrativos. En este artículo se detallan las prácticas y estrategias más relevantes: el diseño e implementación de un programa de especialización en docencia universitaria, la inauguración de un laboratorio de aprendizaje para el fomento del aprendizaje mediante la fabricación digital, los multientornos, y los mapas conceptuales, así como el fortalecimiento de un equipo de innovación curricular. Estos procesos disruptivos han …
Evaluation of a Chemistry Concept Inventory for general chemistry students at Finnish university
2020
A chemistry concept inventory (Chemical Concept Inventory 3.0/CCI 3.0), previously developed for use
 in Norwegian universities, was tested and evaluated for use in a Finnish university setting. The test,
 designed to evaluate student knowledge and learning of chemistry concepts, was administered as both
 pre- and posttest in first year general chemistry courses at the University of Jyväskylä. The results were
 evaluated using different statistical tests, focusing both on individual item analysis and the entire test.
 Some individual questions were found to be not discriminating or reliable enough or too difficult, yet the
 results, as a whole, indicate that th…
A Conceptual Framework for Using and Evaluating Web-Based Learning Resources in School Education
2010
Published version of an article from the journal:Journal of Information Technology Education. Also available from the publisher: http://www.jite.org/documents/Vol9/JITEv9p053-079Hadjerrouit743.pdf Web-based learning resources (WBLRs) have provided teachers with a wide range of new teachingexperiences that are not possible in traditional classroom. However, little research has beendone as to which approach to WBLRs is suitable to address issues that are pertinent to learning.This paper proposes a conceptual framework to explore the design and evaluation of WBLRs inschool education. The paper also examines the way in which the framework is used to evaluatestudents? and teachers? perceptions o…
La representació conceptual del gènere. Una revisió crítica
2013
Des de la perspectiva psicolingüística, diversos treballs s’han preguntat si el gènere es representa a nivell conceptual. En el marc de les noves interpretacions de la hipòtesi del relativisme lingüístic, s’ha proposat que les diferències de gènere (masculí o femení) influencien la conceptualització. Aquest article fa una anàlisi d’alguns dels estudis de referència i argumenta que a partir d’aquests estudis no es pot concloure que el gènere tingui efectes en el pensament no lingüístic. La revisió feta indica que el gènere és una propietat lexicosemàntica dels noms i que es representa lingüísticament, la qual cosa és compatible amb la hipòtesi del Pensar per Parlar. Tanmateix, es defensa que…
A cognitive-based approach to President Obama’s educational discourse through the lens of his State of the Union Addresses (2009-2016)
2017
In order to gain a cultural understanding of the discourse on education used by President Obama, this article examines the source domains commonly used to refer to education in his State of the Union Addresses, from the time he took office in 2009 to 2016 when he will leave office. The study will proceed by applying insights from Conceptual Metaphor Theory (CMT), within the field of cognitive linguistics, supplemented by the Metaphor Identification Procedure (MIP) developed by the Pragglejazz Group. The source domains identified and discussed are: COMPETITION and ECONOMICS. In fact, the strong coherence in Obama’s speeches relies on the use of the story of competition as the concept that is…