Search results for "NERC"
showing 10 items of 57 documents
Factores determinantes de la intención de cambio estratégico: el papel de los equipos directivos
2010
ResumenLa capacidad de una empresa para adaptarse y responder a las oportunidades y presiones del entorno es uno de los aspectos más importantes en la búsqueda de la competitividad y de la supervivencia. Este trabajo pretende mejorar la comprensión de los factores que influyen en la intención de impulsar cambios en el contenido de la estrategia, analizando los factores motivadores y de resistencia tradicionalmente considerados, así como el papel facilitador de las características de los equipos directivos. Nuestros resultados resaltan que la heterogeneidad de los equipos directivos facilita la predisposición a impulsar cambios en las estrategias competitivas y corporativas, y que los cambio…
Dose adjustments and discontinuation in TNF inhibitors treated patients: when and how. A systematic review of literature.
2018
Objectives To review the available evidence concerning the possibility of discontinuing and/or tapering the dosage of TNF inhibitors (TNFi) in RA patients experiencing clinical remission or low disease activity. Methods A systematic review of the literature concerning the low dosage and discontinuation of TNFi in disease-controlled RA patients was performed by evaluation of reports published in indexed international journals (Medline via PubMed, EMBASE), in the time frame from 8 April 2013 to 15 January 2016. Results We analysed the literature evaluating the efficacy and the safety of two different strategies using TNFi, decreasing dosage or discontinuation, in patients experiencing clinica…
AB0438 Safety of tnf blockers in case of non-alcoholic fatty liver disease and cirrhosisa systematic review
2018
Background The management of inflammatory rheumatisms and psoriasis has largely evolved over the last 15 years with the emergence of biotherapies whose main adverse effect is the increased infection risk. The prevalence of metabolic syndrome is increasing and has been estimated at 30% in patients with rheumatoid arthritis with an excess of 45% compared to healthy subjects. One of the major complications of the metabolic syndrome is the Non Alcoholic Fatty Liver Disease (NAFLD), which prevalence is 25% in the global population, and 30% in a cohort of patients with rheumatoid arthritis. The main complication of NAFLD is the development of cirrhosis, known to increase infectious risk. Surprisi…
Mitigating-casi: relation between propositional content and discourse units
2018
El aproximativo casi entraña la inversión polar de su proposición, sin embargo, los usos considerados expletivos presentan valores atenuantes. Este trabajo complementa con un estudio de corpus la descripción teórica del uso expletivo-atenuante en relación con la unidad discursiva de casi en el habla coloquial. La unidad que ocupa en el discurso determina su uso atenuante y supone una prueba efectiva de su naturaleza semántica, al tiempo que aclara ciertas cuestiones de la bibliografía deductiva. This paper explores the mitigating function of Spanish casi and its relation to the discourse units casi fulfills in spoken language. Casi can either entail a polar inversion of the proposition it h…
Divu brīvības pakāpju savienojumu noteikšana ar inerciālajiem sensoriem
2022
Inerciālie sensori ir plaši izmantoti, lai no to datiem aprēķinātu un aprakstītu fizikālu objektu orientācijas. Lai iegūtu orientāciju, kam nav laikā uzkrājoša kļūda, papildus bieži lieto magnētiskā lauka sensorus, kuru mērījumi reālās situācijas mēdz būt trokšņaini. Darbā ir izstrādāts algoritms, kas spēj izmantot inerciālā sensora datus un informāciju par mehānisko sistēmu, lai aprakstītu divu ķermeņu relatīvo orientāciju, neizmantojot magnētiskā lauka sensorus. Ir izveidota eksperimentālā sistēma, kur izstrādātais algoritms salīdzināts ar pieeju, kas lieto komerciālus inerciālo sensoru mezglus, kas izmanto magnētiskā lauka sensorus. Eksperimentos noteiktā algoritma kļūda ir 7.52o, BNO055…
Combination therapy of recalcitrant severe psoriasis with psoriatic arthritis, diabetes nephropathy, and liver cirrhosis
2021
Objective Treatment of recalcitrant moderate-to-severe psoriasis can be challenging. Combination therapy of biologics and immunosuppressive agents can be a new strategy for treating therapy-resistant cases with comorbidities, where many systemic medications are contraindicated. Case presentation We report a case of a 62-year-old diabetic man with a 30-year history of severe plaque psoriasis and psoriatic arthritis with cirrhosis and diabetic nephropathy that was treated successfully in combination with apremilast and etanercept after multiple previous unsuccessful treatment attempts. Conclusion There are no data supporting the combination of apremilast and etanercept in the management of re…
Clinical practice format for choosing a second-line disease modifying anti-rheumatic drug in early rheumatoid arthritis after failure of 6 months' fi…
2006
International audience; BACKGROUND: The objective was to develop a clinical practice format for choosing a second-line disease-modifying anti-rheumatic drug (DMARD) after a 6-month course of a first-line DMARD in patients with early RA. METHODS: A panel of 34 experts selected treatment option from various scenarios using the Thurstone pairwise method. The experts had to choose between two proposed DMARDs without proposing other options. The scenarios were obtained using the three items: DAS28, rheumatoid factor status and radiographic structural damage. A sample of 240 among 480 scenarios for each expert was taken at random. Responses given by at least 20% of the experts were considered per…
A 2-year comparative open label randomized study of efficacy and safety of etanercept and infliximab in patients with ankylosing spondylitis
2010
The signs and symptoms of ankylosing spondylitis (AS) respond inadequately to nonsteroidal antiinflammatory drugs, corticosteroids, and disease modifying antirheumatic drugs in quite a number of patients. Tumor necrosis factor inhibitors have demonstrated to be of value in reducing AS disease activity in clinical trials. The efficacy and safety of both etanercept and infliximab in patients with ankylosing spondylitis were compared in a 2-year open label randomised study. Our results are consistent with a significant more rapid clinical improvement in the infliximab treated group. Treatment with both etanercept and infliximab at the end of the study was effective, safe, and well tolerated. ©…
Disease status, reasons for discontinuation and adverse events in 1038 Italian children with juvenile idiopathic arthritis treated with etanercept
2016
Background: Data from routine clinical practice are needed to further define the efficacy and safety of biologic medications in children with juvenile idiopathic arthritis (JIA). The aim of this analysis was to investigate the disease status, reasons for discontinuation and adverse events in Italian JIA patients treated with etanercept (ETN). Methods: In 2013, all centers of the Italian Pediatric Rheumatology Study Group were asked to make a census of patients given ETN after January 2000. Patients were classified in three groups: group 1 = patients still taking ETN; group 2 = patients discontinued from ETN for any reasons; group 3 = patients lost to follow-up while receiving ETN. All three…
Obesity and reduction of the response rate to anti-tumor necrosis factor α in rheumatoid arthritis: an approach to a personalized medicine.
2013
Objective Obesity is a mild, long-lasting inflammatory disease and, as such, could increase the inflammatory burden of rheumatoid arthritis (RA). The study aim was to determine whether obesity represents a risk factor for a poor remission rate in RA patients requiring anti–tumor necrosis factor α (anti-TNFα) therapy for progressive and active disease despite treatment with methotrexate or other disease-modifying antirheumatic drugs. Methods Patients were identified from 15 outpatient clinics of university hospitals and hospitals in Italy taking part in the Gruppo Italiano di Studio sulle Early Arthritis network. Disease Activity Score in 28 joints (DAS28), body mass index (BMI; categorized …