Search results for "NERVE"

Activation of TRK Genes in Ewingʼs Sarcoma Trk A Receptor Expression Linked to Neural Differentiation

1997

Trk receptors have been identified by immunohistochemical methods in primitive neuroectodermal tumor (PNET)/Ewing's sarcoma (ES). However, the presence of different members of the Trk family of receptors in PNET/ES has not been specified. We have examined whether Trk A, B, and C receptors are specifically expressed in ES both with and without features of neural differentiation. Ten ES tumors (five primary tumors of bone and five extraosseous tumors transplanted into nude mice) were investigated for expression of Trk receptors by immunohistochemistry and reverse transcription-polymerase chain reaction. One primary ES and the five grafted ES tumors exhibited signs of neural differentiation; t…

The Role of Physical Exercise and Rehabilitative Implications in the Process of Nerve Repair in Peripheral Neuropathies: A Systematic Review

2023

Background: The various mechanisms involved in peripheral nerve regeneration, induced by exercise and electrical nerve stimulation, are still unclear. Objective: The aim of this review was to summarize the influence of physical exercise and/or electrical stimulation on peripheral nerve repair and regeneration and the variation of impact of intervention depending on timing, as well as kind and dosage of the intervention. A literature survey was conducted on PubMed, Scopus, and Web of Science, between February 2021 to July 2021, with an update in September 2022. Methodology: The literature search identified 101,386 articles with the keywords: “peripheral nerve” OR “neuropathy” AND “sprouting”…

The Forebrain of the Blind Cave Fish <i>Astyanax hubbsi </i>(Characidae)

1997

This paper presents a survey of the cell groups in the telencephalon of the teleost Astyanax hubbsi, based on series of transverse sections stained with the Nissl-Kluver-Barrera and Bodian procedures. The work was conducted for two reasons. Firstly, it was intended to determine the contribution of the forebrain of blind cave fish to certain forms of behavior. An understanding of the anatomy of the telencephalic organization is essential for such a neuroethological approach. The second purpose was to provide the cytoarchitectural basis for the experimental analysis of the fiber connectivity of the telencephalon of A. hubbsi. Furthermore, information about the forebrain of characids is widely…

Signals regulating neurotrophin expression in glial cells

2001

Mildronate as a Regulator of Protein Expression in a Rat Model of Parkinson’s Disease

2011

Background. Mildronate (3-[2,2,2-trimethylhydrazinium] propionate dihydrate) traditionally is a well-known cardioprotective drug. However, our recent studies convincingly demonstrated its neuroprotective properties. The aim of the present study was to evaluate the influence of mildronate on the expression of proteins that are involved in the differentiation and survival of the nigrostriatal dopaminergic neurons in the rat model of Parkinson’s disease (PD). The following biomarkers were used: heat shock protein 70 (Hsp70, a molecular chaperone), glial cell line-derived nerve growth factor (GDNF, a growth factor promoting neuronal differentiation, regeneration, and survival), and neural cell …

Neurotrophic effects of central nicotinic receptor activation

2000

A growing number of data have shown that compounds interacting with neuronal nicotinic acetylcholine receptors (nAChRs) have, both in vivo and in vitro, the potential to be neuroprotective and that treatment with nAChR agonists elicit long-lasting improvement of cognitive performance in a variety of behavioural tests in rats, monkeys and humans. Epidemiological and clinical studies suggested also a potential neuroprotective/trophic role of (-)-nicotine in neurodegenerative disease, such as Alzheimer's disease and Parkinson's disease. This neuroprotective/trophic role of nAChR activation has been mainly mediated by alpha7 and alpha4beta2 nAChR subtypes, as evidenced using selective nAChR ant…

Medication related to pigmentation of oral mucosa.

2021

The diagnosis of oral melanotic lesions is, more often than not, challenging in the clinical practice due to the fact that there are several reasons which may cause an increase in pigmentation on localized or generalized areas. Among these, medication stands out. In this work, we have carried out a review in the reference pharma database: Micromedex® followed by a review of the scientific published literature to analyse coincidences and possible discrepancies. Our findings show that there are several prescription drugs that can cause pigmented lesions in the oral mucosa. This must be known by clinicians in order to properly diagnose pigmented lesions. We have identified a set of 21 medicame…

Fine adaptive control of precision grip without maximum pinch strength changes after median nerve mobilization

2020

ABSTRACTFine dexterity critically depends on information conveyed by the median nerve. While the effects of its compression and vibration are well characterized, little is known about longitudinal tension and excursion. Using a force-sensitive manipulandum, a numeric dynamometer and Semmes-Weinstein monofilaments, we examined the adaptations of precision grip control, maximum pinch strength and fingertips pressure sensation threshold before and immediately after the application of longitudinal tension and excursion mobilizations applied on the median nerve. Grip (GF) and load (LF) forces applied by the thumb, index and major fingers were collected in 40 healthy young participants during thr…

Text from the theory presentations and lists of objectives. General Anatomy

2022

El document ha sigut revisat pels tècnics del Servei de Política Lingüística, dins de la convocatòria 2021 dels Premis Fernando Sapiña a la qualitat lingüística en l'elaboració de materials docents en valencià i anglés. Text de les presentacions de les classes teòriques i llistes d'objectius de les classes de dissecció per a l'assignatura d'Anatomia General del grup en anglés (ARA) de primer curs del Grau en Medicina. Universitat de València Text from the presentations of the theory classes and lists of objectives of the dissection sessions for the subject of General Anatomy, in the English group (ARA) of the first year in the Degree of Medicine. Universitat de València

Longitudinal Study of Cytokine Expression, Lipid Profile and Neuronal Growth Factors in Human Breast Milk from Term and Preterm Deliveries

2015

Breast milk (BM) is considered as a reference for infant nutrition. The role of bioactive components, such as cytokines, hormones, growth factors (GFs) and fatty acids (FAs) is poorly known, but they might be implicated in immune response development. The aim of this study was to identify the lipid profile and the spectrum of cytokines and neuronal GF in BM samples and analyse the influence of gestational age and lactation time on these components. This study used a longitudinal prospective method for the characterization of cytokines, FAs and GFs global profiles in 120 BM samples from 40 healthy mothers (20 preterm and 20 term) collected as colostrum, transitional and mature milk. The cyto…