Search results for "NEXT"
showing 10 items of 178 documents
Infant exposure of perfluorinated compounds: Levels in breast milk and commercial baby food
2010
In this study, an analytical method to determine six previous termperfluorinatednext term compounds (PFCs) based on alkaline digestion and solid phase extraction (SPE) followed by liquid chromatography-quadrupole-linear ion trap mass spectrometry (LC-QqLIT-MS) was validated for the analysis of human breast milk, milk previous terminfantnext term formulas and cereals baby food. The average recoveries of the different matrices were in general higher than 70% with a relative standard deviation (RSD) lower than 21% and method limits of detection (MLOD) ranging from 1.2 to 362 ng/L for the different compounds and matrices. The method was applied to investigate the occurrence of PFCs in 20 sample…
Walmoo klientu lojalitātes platformas pārvaldes paneļa izstrāde
2022
Kvalifikācijas darba ietvaros ir izstrādāts pārvaldes panelis “Walmoo” klientu lojalitātes platformai. Ar šīs lietotnes palīdzību var pārvaldīt platformā piereģistrētos kontus, to apmeklētājus, apskatīt platformas statistikas datus turpmākai analīzei, kā arī veidot, sūtīt un apskatīt rēķinus. Lietotne pieejama tikai vienam platformā piereģistrētam kontam, kurš ir identificēts kā platformas īpašnieks. Darba mērķis ir izstrādāt jaunu uzlabotu pārvaldes paneļa versiju jau esošajam nepabeigtajam risinājumam. Lietotne ir izstrādāta izmantojot ReactJS satvaru lietotāju saskarnēm ar programmēšanas valodu Typescript, NextJS satvaru, MUI lietotāju saskarnes bibliotēku. Kā arī lietotne ir savienota a…
Lightweight LCP construction for next-generation sequencing datasets
2012
The advent of "next-generation" DNA sequencing (NGS) technologies has meant that collections of hundreds of millions of DNA sequences are now commonplace in bioinformatics. Knowing the longest common prefix array (LCP) of such a collection would facilitate the rapid computation of maximal exact matches, shortest unique substrings and shortest absent words. CPU-efficient algorithms for computing the LCP of a string have been described in the literature, but require the presence in RAM of large data structures. This prevents such methods from being feasible for NGS datasets. In this paper we propose the first lightweight method that simultaneously computes, via sequential scans, the LCP and B…
Automation of Acquisition and Post-processing for 3D Digitalisation
2009
The automation of digitalisation is an indispensable step in the development of 3D measuring, in various fields :- in industry, to accelerate the procedures for control of parts,- in archaeology and biology, for the study of collections of several hundreds even thousand objects (for which the acquisition is for the moment impossible because of necessary time, and thus of the cost). In this thesis, we explain first the various existing systems of acquisition and positioning, by detailing the advantages and the inconveniences of every system. We present then the developed methodology to guide the operator in these choices as well as the tool set up to formalize this methodology. Then we will …
Genomic characterization of mosaic cutaneous pigmentary disorders
2019
Ntroduction: Mosaic cutaneous dyschromia is strongly evocative of an underlying genetic mosaicism. These post-zygotic events are challenging for conventional diagnostic tools. Thus, genetic basis of mosaic cutaneous dyschromia still remained poorly understood. Materials and Methods: The M.U.S.T.A.R.D. cohort gathers DNA from skin biopsies of patients with mosaic cutaneous dyschromia. After a specialised phenotype analysis, they are referred to either trio exome sequencing (ES) at 200X, or targeted ultra-deep sequencing (60,000X) of candidate genes. Data are analysed with a tailored pipeline, allowing detection of both low-rate nucleotidic variations or chromosomal events. Results: From 2013…
Temporal dynamics of soil bacterial communities at a landscape scale: dependence to soil properties and agricultural practices.
2019
International audience; Soil microbial communities play a major role in agricultural functions and are an efficient indicator to evaluate the impacts of agricultural practices on soils. Studies on wide scales ranging from landscape to countries demonstrated that soil microbial communities were heterogeneously distributed in space under the dependence of soil properties (e.g. pH, soil texture, Organic matter Content) and agricultural practices. However, temporal dynamics of soil microbial communities at a landscape scale still need to be documented in order to go further in evaluating the sustainability of agricultural practices. In this extensive monitoring study, we focused on landscape dy…
Tecnologías de secuenciación masiva y PCR digital en la detección de ADN tumoral procedente de tejido y plasma en pacientes de colon localizado
2022
El cáncer de colon se sitúa como uno de los tumores más relevantes a nivel social, con una tasa de entre el 30 y 50% de recaídas tras la resección. Como herramienta de estudio en este tumor, la biopsia líquida se ha abierto paso en diferentes ámbitos, tales como la detección de la heterogeneidad tumoral o la enfermedad mínima residual (EMR). El fundamento de esta estrategia es detectar el ADN tumoral circulante (ctDNA), que se encuentra diluido en el ADN libre circulante (cfDNA), siendo necesario el uso de tecnologías aptas para la detección a frecuencias bajo el 1%. La hipótesis de esta tesis se apoya en variantes somáticas para detectar el ctDNA y definir la heterogeneidad tumoral, la EMR…
A multi-omic liquid biopsy-based signature as a valuable tool to assess minimal residual disease in localised colorectal cancer
2019
El cáncer colorrectal (CCR) es un importante problema de salud pública. Más de 1.2 millones de pacientes se diagnostican de CCR cada año, y más de 600.000 mueren a causa de la enfermedad. El pronóstico de los pacientes con CCR ha mejorado durante las últimas décadas, con una supervivencia a los 5 años que ha alcanzado casi el 65% en países desarrollados. El estadio al diagnóstico es actualmente el factor pronóstico más importante. Aunque la clasificación clásica de estadiaje proporciona información pronóstica y guía las decisiones terapéuticas, no disponemos hoy en día de marcadores predictivos de la respuesta y del resultado clínico de la terapia individual del paciente. Esto es relevante …
CoproID predicts the source of coprolites and paleofeces using microbiome composition and host DNA content
2020
Shotgun metagenomics applied to archaeological feces (paleofeces) can bring new insights into the composition and functions of human and animal gut microbiota from the past. However, paleofeces often undergo physical distortions in archaeological sediments, making their source species difficult to identify on the basis of fecal morphology or microscopic features alone. Here we present a reproducible and scalable pipeline using both host and microbial DNA to infer the host source of fecal material. We apply this pipeline to newly sequenced archaeological specimens and show that we are able to distinguish morphologically similar human and canine paleofeces, as well as non-fecal sediments, fro…
The Experiential Perceptions of Entrepreneurial Competencies : Avenues for the Next-Generation Entrepreneurship Education
2023
AbstractThis self-narrative study on entrepreneurial competencies was conducted among potential next-generation members belonging to entrepreneurial families. As public university bachelor students, self-narratives written by the students themselves do not reflect just perceptions of entrepreneurial competencies in the context of business families but also in the context of higher education. The conceptual advancement of this paper focuses on extending the discussion of entrepreneurial experience-based competencies before designing and launching a venture, such as creativity, innovativeness, risk-taking, sales, and marketing.