Search results for "NOE"

Nanodevices by DNA based gold nanostructures

2017

In this thesis DNA based structures were utilized to create gold nanostructures for nanosensing and nanoelectronic applications. In the past, both of these fields have been dominated by the conventional lithography methods, e.g., electron beam lithography and UV-lithography, but more recently scaling down the components by these techniques has become increasingly more complex and costly. Especially in the micro- and nanoelectronics, the increase in the component density and thus computational power would require fabrication of sub-10-nm components, which is challenging for the top-down approaches. Aforementioned developments have led researchers to seek alternative methods to fabricate these…

Yrittäjämäinen elinkeinopolitiikka : kolmevaiheinen, diskurssianalyyttinen tarkastelu kunnan elinkeinopolitiikan roolista ja tehtävistä

2009

The relationship between the municipality and the state as well the markets and the society is changing dramatically. The decision makers on the municipal level ought to be able to look at today’s world with an unprejudiced insight, to notice the ongoing changes and tendencies, to see the dangers and the possibilities brought about by the changes, to create a common will to agree on values, and to choose the correct methods to reach the desired future. The municipal industrial policy in particular is facing new challenges, and its role among the various functions of the municipality has become all the more important.The present analysis focuses on the industrial policy of the Finnish munici…

Stereoselective Synthesis and Pharmacological Evaluation of 2,4-Bridged Piperidine Derivatives Designed to Activate the κ-Opioid Receptor

2021

Immunohistochemical localization of the pro-peptide processing enzymes PC1/PC3 and PC2 in the human anal canal.

1997

Abstract HORsch, D., R. Day, N. G. Seidah, E. Weihe and M. K.-H. SchAFer. Immunohistochemical localization of the pro-peptide processing enzymes PC1/PC3 and PC2 in the human anal canal. Peptides 18(5) 755–760, 1997.—The distribution of prohormone/pro-peptide convertases PC1/PC3 and PC2 was investigated in the human anal canal by immunohistochemistry. Both prohormone convertases exhibited region-specific distribution patterns and were observed in neural and neuroendocrine cells and in nonneuroendocrine cellular elements. PC1/PC3 immunoreactivity was present in enteric neurons, subsets of nerve fibers, and neuroendocrine cells, and also in epithelial cells like intestinal stem cells, and a su…

Chromogranin A in the Mammalian Merkel Cell: Cellular and Subcellular Distribution

1989

Chromogranin-A (CGA), which accounts for more than half the soluble matrix protein in secretory granules of various neuroendocrine cells, has a wide spectrum of potential biological roles and is considered an important marker of the diffuse neuroendocrine system (DNES). Light and electron microscopic immunohistochemistry of mammalian skin revealed that Merkel cells are exclusively CGA-immunoreactive (ir) and that the immunoreaction is localized in the secretory granules. This finding supports the classification of the Merkel cell as a member of the DNES. The CGA immunoreactivity was restricted to Merkel cells of pigs and humans. In human embryonic skin, CGA was expressed in Merkel cells as …

Ontogeny of gonadotropin releasing hormone and gonadotropin immunoreactivity in brain and pituitary of normal and estrogen-treated guppies, Poecilia …

1987

Gonadotropin releasing hormone (GnRH) and gonadotropic hormone (GTH) were identified by immunohistochemistry in the brains and pituitaries of neonate, juvenile and adult guppies. GTH was present in some cells of the pars intermedia (pi) and proximal pars distalis (ppd) of all animals. GnRH was found in the perikarya of the nucleus olfactoretinalis. In the pituitaries of juvenile 30-day-old guppies, GnRH-immunoreactive cells existed in a "juvenile pattern", whereas in adult animals GnRH was recognized in only a few cells. GnRH-immunoreactive fibers were seen in the pituitaries of animals that were 30 days or older. In adult guppies, the ventral and lateral ppd (the gonadotropic region) conta…

Integrin-mediated Cell Adhesion to Type I Collagen Fibrils

2004

In the integrin family, the collagen receptors form a structurally and functionally distinct subgroup. Two members of this subgroup, α1β1 and α2β1 integrins, are known to bind to monomeric form of type I collagen. However, in tissues type I collagen monomers are organized into large fibrils immediately after they are released from cells. Here, we studied collagen fibril recognition by integrins. By an immunoelectron microscopy method we showed that integrin α2I domain is able to bind to classical D-banded type I collagen fibrils. However, according to the solid phase binding assay, the collagen fibril formation appeared to reduce integrin α1I and α2I domain avidity to collagen and to lower …

Desarrollo de métodos inmunoquímicos para el análisis en alimentos de fungicidas inhibidores de la succinato deshidrogenasa

2017

El uso de plaguicidas constituye una forma eficaz y hoy por hoy necesaria para combatir gran parte de las plagas que afectan a los cultivos agrícolas. Sin embargo, su uso puede dar lugar a la aparición de residuos en los alimentos que llegan al consumidor, lo que puede derivar en un problema de seguridad alimentaria. Por ello, es necesario el desarrollo de métodos analíticos altamente sensibles y selectivos para la monitorización de dichos residuos, que permitan la detección de concentraciones lo más bajas posibles. En este contexto, en esta Tesis Doctoral se ha abordado el desarrollo de métodos inmunoquímicos de elevada sensibilidad y selectividad para el análisis en muestras de alimentos …

Insights on Hydrothermal‐Magmatic Interactions and Eruptive Processes at Poás Volcano (Costa Rica) From High‐Frequency Gas Monitoring and Drone Measu…

2019

Texto completo del documento Identification of unambiguous signals of volcanic unrest is crucial in hazard assessment. Processes leading to phreatic and phreatomagmatic eruptions remain poorly understood, inhibiting effective eruption forecasting. Our 5‐year gas record from Poás volcano, combined with geophysical data, reveals systematic behavior associated with hydrothermal‐magmatic eruptions. Three eruptive episodes are covered, each with distinct geochemical and geophysical characteristics. Periods with larger eruptions tend to be associated with stronger excursions in monitoring data, particularly in SO2/CO2 and SO2 flux. The explosive 2017 phreatomagmatic eruption was the largest erupt…

Distribution and Function of Gap Junction Coupling in Cortical GABAergic Neurons.

2013

Although gap junctions have been observed in GABAergic interneurons of several brain regions, this chapter focuses on the distribution and functions of gap junctions and connexins in inhibitory interneurons of the cerebral cortex and hippocampus. Evidence for interconnections mediated by electrical synapses is reported for at least eight cerebral cortex interneuron types, classified on the basis of morphology, electrophysiology and molecular markers. The main differences in the organization of these interneuronal networks are summarized in terms of homologous and heterologous electrical coupling and mutual chemical inhibition. The role of connexin36 (Cx36) in forming neuronal electrical syn…