Search results for "NOS"
showing 10 items of 30869 documents
Sex Differences in the Physiological Network of Healthy Young Subjects
2021
Within human physiology, systemic interactions couple physiological variables to maintain homeostasis. These interactions change according to health status and are modified by factors such as age and sex. For several physiological processes, sex-based distinctions in normal physiology are present and defined in isolation. However, new methodologies are indispensable to analyze system-wide properties and interactions with the objective of exploring differences between sexes. Here we propose a new method to construct complex inferential networks from a normalization using the clinical criteria for health of physiological variables, and the correlations between anthropometric and blood tests b…
Shadowing e GIS qualitativo: due strumenti per narrare la città
2015
Questo breve articolo descrive la città attraverso due tecniche di ricerca qualitativa (lo shadowing e il GIS qualitativo). Partendo da alcuni esempi, tratti dall’esperienza sul campo, vengono valutati limiti e possibilità delle tecniche in oggetto. L’obiettivo è quello di argomentare la necessità di utilizzare e sviluppare nuovi strumenti metodologici per conoscere le configurazioni urbane. Gli autori sostengono il bisogno di muoversi all’interno di un orizzonte interdisciplinare e di utilizzare tecniche capaci di far emergere narrazioni polifoniche della città. Analizzando le potenzialità dialogiche dello shadowing e le potenzialità sovversive dei GIS qualitativi, una cartografia capace d…
A Shape-based Statistical Method to Retrieve 2D TRUS-MR Slice Correspondence for Prostate Biopsy
2012
International audience; This paper presents a method based on shape-context and statistical measures to match interventional 2D Trans Rectal Ultrasound (TRUS) slice during prostate biopsy to a 2D Magnetic Resonance (MR) slice of a pre-acquired prostate volume. Accurate biopsy tissue sampling requires translation of the MR slice information on the TRUS guided biopsy slice. However, this translation or fusion requires the knowledge of the spatial position of the TRUS slice and this is only possible with the use of an electro-magnetic (EM) tracker attached to the TRUS probe. Since, the use of EM tracker is not common in clinical practice and 3D TRUS is not used during biopsy, we propose to per…
Charged jet cross sections and properties in proton-proton collisions at $\sqrt{s}=7$ TeV
2015
The differential charged jet cross sections, jet fragmentation distributions, and jet shapes are measured in minimum bias proton-proton collisions at centre-of-mass energy $\sqrt{s}=7$ TeV using the ALICE detector at the LHC. Jets are reconstructed from charged particle momenta in the mid-rapidity region using the sequential recombination $k_{\rm T}$ and anti-$k_{\rm T}$ as well as the SISCone jet finding algorithms with several resolution parameters in the range $R=0.2$ to $0.6$. Differential jet production cross sections measured with the three jet finders are in agreement in the transverse momentum ($p_{\rm T}$) interval $20<p_{\rm T}^{\rm jet,ch}<100$ GeV/$c$. They are also consistent w…
Polymeric nanoparticles for siRNA delivery: Production and applications
2017
Gene therapy through the use of siRNA and a polymeric carrier are becoming an efficient therapeutic option to conventional pharmaceutical formulations for the treatment of deadly diseases, such as cancer, pulmonary, ocular and neurodegenerative diseases. However, several considerations regarding the stability, formulation, and efficacy have to be faced up until these systems could be considered to be a marketable pharmaceutical products for to extend siRNA application to clinical practice. This review is focused on the key challenges of siRNA therapeutics, with special attention on the faced obstacles and on the formulation-related difficulties, providing a list of requirements needed for o…
Development of New Targeted Inulin Complex Nanoaggregates for siRNA Delivery in Antitumor Therapy.
2021
Here, a novel strategy of formulating efficient polymeric carriers based on the already described INU-IMI-DETA for gene material whose structural, functional, and biological properties can be modulated and improved was successfully investigated. In particular, two novel derivatives of INU-IMI-DETA graft copolymer were synthesized by chemical functionalisation with epidermal growth factor (EGF) or polyethylenglycol (PEG), named INU-IMI-DETA-EGF and INU-IMI-DETA-PEG, respectively, in order to improve the performance of already described “inulin complex nanoaggregates” (ICONs). The latter were thus prepared by appropriately mixing the two copolymers, by varying each component from 0 to 100 wt%…
Development of different nanosystems for drugs and siRNA delivery
Cancer is one of the leading causes of death in the world. Over the past several decades, the development of engineered nanosystems for targeted drug delivery have received great attention thanks to their possibility to overcome the limitations of classical cancer chemotherapy including poor solubility, targeting incapability, nonspecific action and, consequently, systemic toxicity. In this contest, four different models of nanocarriers have been analysed and compared for their capacity to target tumour tissue and to release the therapeutic agent in a controlled way: INU-EDA-P,C-DOXO; PHEA-EDA-P,C-DOXO; PVP-siRNA and RGO-siRNA. Inulin and PHEA were conjugated to the antineoplastic drug doxo…
Archivio Storico Diocesano
2015
Il testo presenta in breve le vicende relative alla costituzione e, al contempo, le peculiarità dell'Archivio Storico Diocesano di Palermo (ASDPa), coi suoi fondi membranacei e cartacei in lingua latina, greca, araba e siriaca, i sigilli, i manoscritti miniati datati dall'XI al XVII secolo e legati al Capitolo Metropolitano; con la cospicua documentazione moderna (XV-XX secolo) utilissima come fonte per gli studiosi di storia, storia dell'arte, demografia, genealogia e quant'altro; con il suo fondo librario specialistico a stampa antico e moderno. The text briefly presents the events relating to the establishment and, at the same time, the peculiarities of the Diocesan Historical Archive of…
Applying Hilbert-Huang transform to mismatch negativity
2009
Siian rakkoloision (Henneguya zschokkei) elämänkierto sekä esiintyminen kalassa ja harvasukamadossa
2010
Siian rakkoloisio (Henneguya zschokkei) on Myxozoa-pääjaksoon kuuluva itiöloinen. Myxozoa-loisilla on monimutkainen elämänkierto, joka pitää sisällään sekä selkärangattoman että selkärankaisen isäntäeliön. Siian rakkoloision pääisäntä on harvasukamato (Oligochaeta) ja väli-isäntä on siika (Coregonus lavaretus). Rakkoloisiota on tavattu mahdollisesti myös muikulla (C. albula). Loisitun kalan lihaksessa on valkoisia ellipsin muotoisia kystejä, joiden sisällä on maitomaista nestettä. Neste sisältää suuren määrän mikroskooppisia kaksihäntäisiä myksospoori-itiöitä. Kalan lihaksessa voi olla useita, jopa satoja erikokoisia kystejä. Loinen aiheuttaa ongelmia niin kalanviljelyssä kuin vapaa-ajankal…