Search results for "NOTA"
showing 10 items of 592 documents
Changes in the Transcriptome Profiles of Human Amnion-Derived Mesenchymal Stromal/Stem Cells Induced by Three-Dimensional Culture: A Potential Primin…
2022
Mesenchymal stromal/stem cells (MSCs) are believed to function in vivo as a homeostatic tool that shows therapeutic properties for tissue repair/regeneration. Conventionally, these cells are expanded in two-dimensional (2D) cultures, and, in that case, MSCs undergo genotypic/phenotypic changes resulting in a loss of their therapeutic capabilities. Moreover, several clinical trials using MSCs have shown controversial results with moderate/insufficient therapeutic responses. Different priming methods were tested to improve MSC effects, and three-dimensional (3D) culturing techniques were also examined. MSC spheroids display increased therapeutic properties, and, in this context, it is crucial…
Strategies for annotation and curation of translational databases: the eTUMOUR project
2012
Altres ajuts: LSHC/CT2004-503094 The eTUMOUR (eT) multi-centre project gathered in vivo and ex vivo magnetic resonance (MR) data, as well as transcriptomic and clinical information from brain tumour patients, with the purpose of improving the diagnostic and prognostic evaluation of future patients. In order to carry this out, among other work, a database-the eTDB-was developed. In addition to complex permission rules and software and management quality control (QC), it was necessary to develop anonymization, processing and data visualization tools for the data uploaded. It was also necessary to develop sophisticated curation strategies that involved on one hand, dedicated fields for QC-gene…
Ge-doping dependence of gamma-ray induced germanium lone pair centers in Ge-doped silica
2008
We report an experimental study on the y irradiation effects in Ge-doped sol-gel silica samples doped with Ge from 10 2 up to 10 4 part per million molar. The samples were exposed to the radiation generated by a 60 Co source up to an accumulated dose value of 10 MGy. Our data evidence that the γ irradiation significantly increases the number of Germanium Lone Pair Centers (GLPC). Such defects are induced with a concentration that depends on the Ge content of the employed material in those samples where no optical activity related to -s GLPC was detected before irradiation. Furthermore an increase of the GLPC concentration was detected also in a sample that already contains this defect after…
Optimitzant el diàleg necessari entre ciutat, museu i educació artística
2015
Recensió
The Algorithm of a Game-Based System in the Relation between an Operator and a Technical Object in Management of E-Commerce Logistics Processes with …
2021
Machine learning (ML) is applied in various logistic processes utilizing innovative techniques (e.g., the use of drones for automated delivery in e-commerce). Early challenges showed the insufficient drones’ steering capacity and cognitive gap related to the lack of theoretical foundation for controlling algorithms. The aim of this paper is to present a game-based algorithm of controlling behaviours in the relation between an operator (OP) and a technical object (TO), based on the assumption that the game is logistics-oriented and the algorithm is to support ML applied in e-commerce optimization management. Algebraic methods, including matrices, Lagrange functions, systems of differential e…
Perturbative quantum field theory
2000
pQFT In this chapter we repeat the main steps towards a derivation of the Feynman rules, following the well-known path of canonical quantization. This is standard material, and readers who are not acquainted with such topics are referred to [Bjorken and Drell 1965, Bogoliubov and Shirkov 1980, Itzykson and Zuber 1980, Kaku 1993, Weinberg 1995, Peskin and Schroeder 1995, Teller 1997]. We hope that the short summary given here, similar to that in [Kreimer 1997a], is helpful for readers who want to refresh their memory. Having introduced Feynman rules, we next introduce Schwinger–Dyson equations as a motivation for the introduction of Z -factors. We remark on dimensional regularization and giv…
RepeatsDB in 2021: improved data and extended classification for protein tandem repeat structures
2020
The RepeatsDB database (URL: https://repeatsdb.org/) provides annotations and classification for protein tandem repeat structures from the Protein Data Bank (PDB). Protein tandem repeats are ubiquitous in all branches of the tree of life. The accumulation of solved repeat structures provides new possibilities for classification and detection, but also increasing the need for annotation. Here we present RepeatsDB 3.0, which addresses these challenges and presents an extended classification scheme. The major conceptual change compared to the previous version is the hierarchical classification combining top levels based solely on structural similarity (Class > Topology > Fold) with two new lev…