Search results for "NPO"
showing 10 items of 336 documents
Associations of Pathogenic Variants in MLH1, MSH2, and MSH6 With Risk of Colorectal Adenomas and Tumors and With Somatic Mutations in Patients With L…
2020
Contains fulltext : 220040.pdf (Publisher’s version ) (Closed access) BACKGROUND & AIMS: Lynch syndrome is caused by variants in DNA mismatch repair (MMR) genes and associated with an increased risk of colorectal cancer (CRC). In patients with Lynch syndrome, CRCs can develop via different pathways. We studied associations between Lynch syndrome-associated variants in MMR genes and risks of adenoma and CRC and somatic mutations in APC and CTNNB1 in tumors in an international cohort of patients. METHODS: We combined clinical and molecular data from 3 studies. We obtained clinical data from 2747 patients with Lynch syndrome associated with variants in MLH1, MSH2, or MSH6 from Germany, the Net…
HSP110 T17 simplifies and improves the microsatellite instability testing in patients with colorectal cancer
2016
IF 5.65; International audience; Background Every colorectal cancer (CRC) patient should be tested for microsatellite instability (MSI, a marker for defective DNA mismatch repair) as a first screen for Lynch syndrome (LS). In this study, we investigated whether it may be possible to improve the detection of MSI in CRC. We examined whether the HT17 DNA repeat (critical for correct splicing of the chaperone HSP110) might constitute a superior marker for diagnosis of the MSI phenotype in patients with CRC compared with the standard panel of markers (pentaplex).Methods The HT17 polymorphism was analysed in germline DNA from 1037 multi-ethnic individuals. We assessed its sensitivity and specific…
Immunization Status against Measles of Health-Care Workers Operating at Three Sicilian University Hospitals: An Observational Study
2019
Measles is a highly contagious vaccine-preventable disease (VPD) that also commonly affects health-care workers (HCWs). Measles immunization of HCWs was strongly recommended by international health authorities, in order to limit the spreading of the illness to susceptible patients and colleagues. An observational study, evaluating the immunization and vaccination status against measles of HCWs working at three Sicilian university hospitals, was conducted. All subjects not completely immune (vaccinated with only one dose in their lifetime), not immune (not vaccinated or not naturally immunized), and with an unknown immunization status were considered not immunized. Among HCWs operating in th…
Impact of Communicative and Informative Strategies on Influenza Vaccination Adherence and Absenteeism from Work of Health Care Professionals Working …
2019
Every year, about 20% of health care workers (HCWs) acquire influenza, continuing to work and encouraging virus spreading. Influenza vaccination coverage rates and absenteeism from work among HCWs of the University Hospital (UH) of Palermo were analyzed before and after the implementation of several initiatives in order to increase HCWs&rsquo
Risk-reducing hysterectomy and bilateral salpingo-oophorectomy in female heterozygotes of pathogenic mismatch repair variants: a Prospective Lynch Sy…
2021
Abstract Purpose To determine impact of risk-reducing hysterectomy and bilateral salpingo-oophorectomy (BSO) on gynecological cancer incidence and death in heterozygotes of pathogenic MMR ( path_MMR ) variants. Methods The Prospective Lynch Syndrome Database was used to investigate the effects of gynecological risk-reducing surgery (RRS) at different ages. Results Risk-reducing hysterectomy at 25 years of age prevents endometrial cancer before 50 years in 15%, 18%, 13%, and 0% of path_MLH1 , path_MSH2 , path_MSH6 , and path_PMS2 heterozygotes and death in 2%, 2%, 1%, and 0%, respectively. Risk-reducing BSO at 25 years of age prevents ovarian cancer before 50 years in 6%, 11%, 2%, and 0% and…
A loss of status and a sense of defeat
2007
This longitudinal study among Spanish teachers (N = 558) examined burnout from an evolutionary social rank perspective. The types of stress differed among various school levels, and a sense of defeat was highest among teachers in primary schools. A low status, a loss of status and a sense of defeat were independent cross‐sectional predictors of burnout. Longitudinally a sense of defeat predicted an increase in burnout over time, especially among males and teachers in high schools. The status related variables were in general more important predictors of burnout than stressors that are usually associated with burnout. Copyright © 2007 John Wiley & Sons, Ltd.
Improvements in Mindfulness Facets Mediate the Alleviation of Burnout Dimensions
2020
Abstract Objectives While interventions using mindfulness have been effective in treating burnout, the mechanisms of change need more research. This study investigated which of five mindfulness facets (observing, describing, acting with awareness, non-judging, and non-reacting) mediated the intervention effects on three burnout dimensions (exhaustion, cynicism, and reduced professional efficacy) during an 8-week mindfulness-, acceptance-, and value-based (MAV) intervention and a 10-month follow-up. Methods The participants were a heterogeneous sample of employees suffering from burnout (n = 202, 80% women, mean age = 47.5 years). Latent change score modeling was conducted for each combinati…
Testing the Intermediary Role of Perceived Stress in the Relationship between Mindfulness and Burnout Subtypes in a Large Sample of Spanish Universit…
2020
The burnout syndrome is the consequence of chronic stress that overwhelms an individual&rsquo
On the "Strength" of Behavior.
2020
AbstractThe place of the concept of response strength in a natural science of behavior has been the subject of much debate. This article reconsiders the concept of response strength for reasons linked to the foundations of a natural science of behavior. The notion of response strength is implicit in many radical behaviorists’ work. Palmer (2009) makes it explicit by applying the response strength concept to three levels: (1) overt behavior, (2) covert behavior, and (3) latent or potential behavior. We argue that the concept of response strength is superfluous in general, and an explication of the notion of giving causal status to nonobservable events like latent behavior or response strengt…
Ajatuksella ja ahkeruudella kolmen suvun vaiheista neljältä vuosisadalta
2018
Kirja-arvio teoksesta Immonen, Perttu: Suomen rahvaan historia. Kolmen suvun elämää keskiajalta 1800-luvulle. Atena Kustannus Oy, 2017. 639 sivua. ISBN 978- 952-300-335-4. Perttu Immonen yhdistää teoksessaan mielenkiintoisesti ja elävästi mikro- ja makrohistorian varhaismodernin ajan Suomessa. Hän seuraa kronologisesti kolmen eri seutukunnan: LänsiSuomen Sastamalan, Itä-Suomen Rantasalmen ja Pohjanmaan Kokkolan tapahtumia. Poikkeuksellisen ankarien aikojen kuvauksesta muodostuu moniulotteinen ja alueiden erilaisia kohtaloita tarkasteleva analyysi. nonPeerReviewed