Search results for "NPR."
showing 10 items of 144 documents
The enantiomers of phenprocoumon: pharmacodynamic and pharmacokinetic studies.
1976
The pharmacodynamics and pharmacokinetics of the optical enantiomers of phenprocoumon were studied in 5 normal subjects and compared to the racemic mixture. Each subject received a single oral dose of 0.6 mg/kg of racemic, S(-), and R(+) phenprocoumon. S(-) phenprocoumon was 1.6 to 2.6 times as a potent as R(+) phenprocoumon when the area under the effect/time curve was used to quantify the total anticoagulant effect per dose. Comparing the plasma concentrations that elicited the same anticoagulant effect, S(-) phenprocoumon was 1.5 to 2.5 times as potent as R(+) phenprocoumon. The anticoagulant activity of the racemic mixture was between that of the enantiomers. There was no distinct diffe…
Factors associated with efficacy of an ibuprofen/pseudoephedrine combination drug in pharmacy customers with common cold symptoms
2016
SummaryAim The aim of this study was to explore factors affecting efficacy of treatment of common cold symptoms with an over-the-counter ibuprofen/pseudoephedrine combination product. Methods Data from an anonymous survey among 1770 pharmacy customers purchasing the combination product for treatment of own common cold symptoms underwent post-hoc descriptive analysis. Scores of symptoms typically responsive to ibuprofen (headache, pharyngeal pain, joint pain and fever), typically responsive to pseudoephedrine (congested nose, congested sinus and runny nose), considered non-specific (sneezing, fatigue, dry cough, cough with expectoration) and comprising all 11 symptoms were analysed. Multiple…
Clopidogrel and aspirin in the prevention of thromboembolic complications after mechanical aortic valve replacement (CAPTA)
2003
Axel Schlitt*, Ralf S. von Bardeleben, Anne Ehrlich, Antje Eimermacher, Dirk Peetz, Manfred Dahm, Hans J. Rupprecht Department of Medicine II, Johannes Gutenberg-University Mainz, Langenbeckstr. 1, 55131 Mainz, Germany Coordination Center for Clinical Studies, Johannes Gutenberg-University Mainz, Mainz, Germany Clinic for Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg-University Mainz, Mainz, Germany Department of Cardiothoracic and Vascular Surgery, Johannes Gutenberg-University Mainz, Mainz, Germany
Monitoring prothrombin fragment 1+2 during initiation of oral anticoagulant therapy after intracoronary stenting
1992
Patients with intracoronary stent implantation are treated with aggressive anticoagulant and antiplatelet therapy consisting of high-dose heparin, phenprocoumon, acetylsalicylic acid, dipyridamole, and the infusion of dextran to prevent a subacute thrombotic occlusion of the stented segment. In an effort to optimize this treatment by reducing both imminent bleeding complications and subacute thrombotic occlusion, the concentrations of prothrombin fragment 1 + 2 (F 1 + 2) were determined after intracoronary Palmaz-Schatz stent implantation in 19 consecutive patients. The F 1 + 2 concentrations after stent implantation and before the initiation of oral anticoagulant therapy (OAT) were 0.35 nm…
Phenprocoumon-induced liver disease ranges from mild acute hepatitis to (sub-) acute liver failure
2003
Abstract Background/Aims Except for bleeding complications, other serious adverse reactions of coumarin anticoagulants such as hepatotoxicity or skin necrosis are comparatively rare. Nonetheless, a small number of coumarin-induced (sub-) acute liver failures has been published. Methods A retrospective analysis was performed of patients treated for liver disease between 1992 and 2002 at our department to evaluate the incidence, clinical findings and histopathology of coumarin-induced hepatotoxicity. Results The retrospective analysis revealed eight cases of phenprocoumon-induced hepatotoxicity, including three cases of (sub-) acute liver failure which resulted in two orthotopic liver transpl…
Distinctive Representation of Mispredicted and Unpredicted Prediction Errors in Human Electroencephalography
2015
The predictive coding model of perception proposes that neuronal responses are modulated by the amount of sensory input that the internal prediction cannot account for (i.e., prediction error). However, there is little consensus on what constitutes nonpredicted stimuli. Conceptually, whereas mispredicted stimuli may induce both prediction error generated by prediction that is not perceived and prediction error generated by sensory input that is not anticipated, unpredicted stimuli involves no top-down, only bottom-up, propagation of information in the system. Here, we examined the possibility that the processing of mispredicted and unpredicted stimuli are dissociable at the neurophysiologic…
Screening of pharmacologic adulterant classes in herbal formulations using voltammetry of microparticles.
2013
A solid state electrochemical method for screening different families of adulterant chemicals illegally added to commercial phytotherapuetic formulations is described. The proposed method, based on the voltammetry of microparticles approach, permits a fast and sensitive way to distinguish between anorexics (amfepramone, fenproporex, sibutramine), benzozodiazepinic anxiolytics (clonazepam, flurazepam, alprazolam, midazolam, medazepam, chlordiazepoxide, diazepam), antidepressants (bupropione, fluoxetine, sertraline, paroxetine), diuretics (hydrochlorothiazide, furosemide, chlortalidone, amiloride, spironolactone), and hypoglycemics (glimepiride, chlorpropamide, glibenclamide) based on charact…
Particle size distributions of currently used pesticides in a rural atmosphere of France
2013
This work presents first data on the particle size distributions of current-used pesticides in the atmosphere. Ambient air samples were collected using a cascade impactor distributed into four size fractions in a rural site of Centre Region (France). Most pesticides were accumulated in the fine (0.1-1 mu m) particle size fraction such as cyprodinil, pendimethalin, fenpropidin, fenpropimorph and spiroxamine. Other pesticides such as acetochlor and metolachlor presented a bimodal distribution with maximum concentrations in the ultrafine (0.03-0.1 mu m) coarse (1-10 mu m) and in the ultrafine fine size ranges, respectively. No pesticides were detected in the size fraction >10 mu m. (C) 2013 El…
Verso una dimensione narrativa delle mappe
2021
Tra il pensiero e la costruzione dell’architettura il disegno ha un ruolo baricentrico per connettere i diversi protagonisti di una realizzazione e per coinvolgere la collettività facendo percepire inedite prospettive. La scrittura si rivela utile per esplicitare ciò che nella grafica è sotteso e per stabilire un ordine nuovo nel ragionamento progettuale. I rapporti fra segni e significati si moltiplicano nei sistemi informativi recenti in cui si ha la sensazione di poter dire moltissimo (dati numerici e spaziali) ma a volte sfugge quella sintesi indispensabile per una interpretazione concreta, finalizzata alla costruzione di possibili esperienze fisiche. Per l’esplorazione dell’uso di dive…
L’autonomia di spesa delle Regioni fra Stato ed Unione europea dalla l. cost. 3/2001 alle condizionalità europee sulla ripresa e la resilienza
2021
L'articolo ricostruisce la tendenza all’accentramento nel governo delle finanze pubbliche e l’eccessiva distanza fra testo costituzionale e diritto costituzionale vivente per analizzare l'attuazione del Recovery Plan (PNRR) rilevando un ulteriore tendenza all’accentramento del governo della spesa. Si indagano dunque le ragioni della compressione dell’autonomia finanziaria di spesa per effetto del principio di indifferenza e del “doppio intreccio federale”. Si mira a inquadrare il tema alla luce della leale collaborazione e dellala resilienza istituzionale per accorciare la “distanza” fra testo costituzionale ed attuazione costituzionale in tema di autonomia di spesa delle Regioni. Si prospe…