6533b870fe1ef96bd12cf129

RESEARCH PRODUCT

Screening of pharmacologic adulterant classes in herbal formulations using voltammetry of microparticles.

María Teresa Doménech-carbóLeandro Machado De CarvalhoAntonio Doménech-carbóCarine VianaMariele MartiniMiguel F. Silva

subject

AdulterantChromatographyFlurazepamChemistryChemistry PharmaceuticalClinical BiochemistryAmfepramoneDrug Evaluation PreclinicalPharmaceutical ScienceElectrochemical TechniquesPharmacologyFenproporexMicrospheresAnalytical ChemistryMedazepamGlimepirideHydrochlorothiazideDrug DiscoverymedicinePlant PreparationsDrug ContaminationDiazepamSpectroscopymedicine.drug

description

A solid state electrochemical method for screening different families of adulterant chemicals illegally added to commercial phytotherapuetic formulations is described. The proposed method, based on the voltammetry of microparticles approach, permits a fast and sensitive way to distinguish between anorexics (amfepramone, fenproporex, sibutramine), benzozodiazepinic anxiolytics (clonazepam, flurazepam, alprazolam, midazolam, medazepam, chlordiazepoxide, diazepam), antidepressants (bupropione, fluoxetine, sertraline, paroxetine), diuretics (hydrochlorothiazide, furosemide, chlortalidone, amiloride, spironolactone), and hypoglycemics (glimepiride, chlorpropamide, glibenclamide) based on characteristic voltammetric signals recorded on solid micro- or nanosamples attached to graphite electrodes immersed into aqueous electrolytes.

yearjournalcountryeditionlanguage
2013-02-01Journal of pharmaceutical and biomedical analysis
10.1016/j.jpba.2012.10.031https://pubmed.ncbi.nlm.nih.gov/23245251