Search results for "NPR."
showing 10 items of 144 documents
Displacement of phenprocoumon (Marcumar) from albumin by sulfonylurea compounds, suramin, and ioglycamic acid.
1972
The technique of Sephadex gel filtration was employed to characterize the effect of some sulfonylurea compounds, ioglycamic acid, and suramin on the binding of phenprocoumon to bovine serum albumin.
Utilization of long duration high-volume sampling coupled to SPME-GC-MS/MS for the assessment of airborne pesticides variability in an urban area (St…
2016
Atmospheric samples have been collected between 14 March and 12 September 2012 on a 2-week basis (15 days of sampling and exchange of traps each 7 days) in Strasbourg (east of France) for the analysis of 43 pesticides. Samples (particle and gas phases) were separately extracted using Accelerated Solvent Extraction (ASE) and pre-concentrated by Solid Phase Micro-Extraction (SPME) before analysis by gas chromatography coupled to tandem mass spectrometry (GC-MS/MS). Four SPME consecutive injections at distinct temperatures were made in order to increase the sensitivity of detection for the all monitored pesticides. Currently used detected pesticides can be grouped in four classes; those used i…
Carnosine Inhibits Aβ42Aggregation by Perturbing the H-Bond Network in and around the Central Hydrophobic Cluster
2013
Aggregation of the amyloid-β peptide (Aβ) into fibrillar structures is a hallmark of Alzheimer's disease. Thus, preventing self-assembly of the Aβ peptide is an attractive therapeutic strategy. Here, we used experimental techniques and atomistic simulations to investigate the influence of carnosine, a dipeptide naturally occurring in the brain, on Aβ aggregation. Scanning force microscopy, circular dichroism and thioflavin T fluorescence experiments showed that carnosine does not modify the conformational features of Aβ42 but nonetheless inhibits amyloid growth. Molecular dynamics (MD) simulations indicated that carnosine interacts transiently with monomeric Aβ42 by salt bridges with charge…
Autonomie e controlli della Corte dei conti nel quadro dei principi costituzionali e dei vincoli sovranazionali in materia economico-finanziaria
2022
Una riflessione dei controlli sulle autonomie territoriali intestati alla Corte dei conti non può prescindere dal loro inquadramento costituzionale. L’A. prospetta una ricostruzione del controllo come espressione di una funzione neutra e imparziale che deve riposare su precisi parametri costituzionali che ne legittimano l’adozione e di cui va resa una stretta interpretazione: il controllo sulle Autonomie territoriali deve così essere necessariamente una attività tale da avvicinarla a quella giurisdizionale piuttosto che amministrativa. È in tale chiave che deve essere inteso il rapporto fra ausiliarietà di cui all’art. 100 Cost. e controlli sui bilanci ed i rendiconti. L’evoluzione del quad…
A new testing device for the role of the trunk in force production and in balance control in disabled sitting athletes
2017
In cross-country sit-skiing all athletes compete in a sitting position, but some of them have the ability to control their trunk more than others. The trunk plays an essential role in two performance determinants: propulsion generation and balance maintenance. The aim of the study is to design a new testing device assessing athletes’ responses to these propulsion determinants. The new device was composed of a seat surrounded by a sensorized aluminum frame. To assess propulsion generation, two force sensors were mounted in the anterior and posterior side of the frame, while two force sensors were embedded in two ropes elongated from the top of the frame. To measure trunk control, the device …
Latvijas automašīnu numura zīmju atpazīšana no video plūsmas
2015
Darba mērķis Panākt, lai atvērtā pirmkoda numura zīmju atpazīšanas risinājums darbojas ne sliktāk kā komerciālais risinājums. Darba saturs Bakalaura darbā tika pētīts vai atvērtā pirmkoda numura zīmju atpazīšanas risinājums spēj sasniegt tikpat labus rezultātus kā komerciālie risinājumi. Tiek apskatīts vispārējs numura zīmju atpazīšanas algoritms, OpenALPR uzbūve, apmācība un pielāgošana, kā arī veikta atvērtā pirmkoda risinājumu salīdzināšana ar komerciālajiem risinājumiem. Secinājumi Lai gan, izmantojot atvērtā pirmkoda numura zīmju atpazīšanas programmatūru, ir iespējams salīdzinoši precīzi veikt numura zīmes attēla pārveidošanu tekstā, pašas numura zīmes atrašanās vietas noteikšana attē…
Plēsonīgas cenas jēdziens un vērtējums Latvijas un Eiropas Savienības konkurences tiesībās.
2018
Maģistra darba temats “Plēsonīgas cenas jēdziens un vērtējums Latvijas un Eiropas Savienības konkurences tiesībās” ir aktuāls temats gan tiesību doktrīnā, gan konkurences tiesību iestāžu piemērošanas praksē, šī jēdziena – plēsonīga cena – pastāvošo pretrunu un neskaidrības dēļ. Praksē līdz šim nav izveidota un tiesību zinātnes eksperti nav vienojušies par vienu konkrētu plēsonīgas cenas definīciju, tieši tā iemesla dēļ, ka jēdziens katrā individuālā lietā tiek vērtēts, analizēts un definēts balstoties uz lietā pieejamajiem faktiskajiem apstākļiem. Līdz ar to darba mērķis ir definēt plēsonīgu cenu un izvērtēt pamatkritērijus, kuri jāņem vērā, lai noteiktu vai tirgus dalībnieks piemērojot plē…
Species-dependent stereospecific serum protein binding of the oral anticoagulant drug phenprocoumon
1978
13 mammalian species are classified into 3 clearcut groups with respect to the stereospecific serum protein-binding of phenprocoumon: 2 groups showing opposed stereospecific binding characteristics and a 3rd group exhibiting no stereospecific binding. Structural differences in the albumin molecule account for these stereospecific differences in serum protein-binding.
La Economia social valenciana ante los conceptos emergentes relacionados en europa
2017
El estudio analiza los diferentes conceptos relacionados con la economia social en Europa aparecidos desde la pasada década, como empresas sociales, economía circular, responsabilidad social, economía solidaria, economía del bien común y otros. El estudio analiza los diferentes conceptos relacionados con la economia social en Europa aparecidos desde la pasada década, como empresas sociales, economía circular, responsabilidad social, economía solidaria, economía del bien común y otros.
The welfare cost of unpriced heterogeneity in insurance markets
2016
We consider the welfare loss of unpriced heterogeneity in insurance markets, which results when private information or regulatory constraints prevent insurance companies to set premiums reflecting expected costs. We propose a methodology which uses survey data to measure this welfare loss. After identifying some “types” which determine expected risk and insurance demand, we derive the key factors defining the demand and cost functions in each market induced by these unobservable types. These are used to quantify the efficiency costs of unpriced heterogeneity. We apply our methods to the US Long-Term Care and Medigap insurance markets, where we find that unpriced heterogeneity causes substan…