6533b830fe1ef96bd1297bef

RESEARCH PRODUCT

Species-dependent stereospecific serum protein binding of the oral anticoagulant drug phenprocoumon

W. SchmidtE. Jähnchen

subject

DrugSwinemedia_common.quotation_subjectGuinea PigsSerum proteinStructural differencePhenprocoumonMiceCellular and Molecular NeuroscienceDogsStereospecificitySpecies SpecificitymedicineAnimalsHumansHorsesMolecular BiologySerum Albuminmedia_commonPharmacologyChemistryGoatsAlbuminStereoisomerism4-HydroxycoumarinsHaplorhiniCell BiologyRatsBiochemistryCatsPhenprocoumonOral anticoagulantMolecular MedicineCattleRabbitsProtein Bindingmedicine.drug

description

13 mammalian species are classified into 3 clearcut groups with respect to the stereospecific serum protein-binding of phenprocoumon: 2 groups showing opposed stereospecific binding characteristics and a 3rd group exhibiting no stereospecific binding. Structural differences in the albumin molecule account for these stereospecific differences in serum protein-binding.

yearjournalcountryeditionlanguage
1978-10-15Experientia
https://doi.org/10.1007/bf01981447