Search results for "NPT"

showing 7 items of 7 documents

Assessment of genetically modified cotton GHB614 × LLCotton25 × MON 15985 for food and feed uses, under Regulation (EC) No 1829/2003 (application EFS…

2018

The three-event stack cotton GHB614 x LLCotton25 x MON 15985 was produced by conventional crossing to combine three single cotton events, GHB614, LLCotton25 and MON 15985. The EFSA GMO Panel previously assessed the three single events and did not identify safety concerns. No new data on the single events that could lead to modification of the original conclusions on their safety were identified. Based on the molecular, agronomic, phenotypic and compositional characteristics, the combination of the single events and of the newly expressed proteins in the three-event stack cotton did not give rise to food and feed safety or nutritional issues. Food and feed derived from cotton GHB614 x LLCott…

0106 biological sciences0301 basic medicineVeterinary (miscellaneous)[SDV]Life Sciences [q-bio]Plant ScienceTP1-1185Biology01 natural sciencesMicrobiology03 medical and health sciencesEnvironmental safetyNPTIIGUSCry1AcTX341-641cotton GHB614 × LLCotton25 × MON 15985Cry2Ab2cotton GHB614 x LLCotton25 x MON 159852. Zero hungerAnimal healthbusiness.industryNutrition. Foods and food supplyGMOChemical technologyRegulation (EC) 1829/2003Food safetyGenetically modified organismBiotechnologySettore AGR/02 - Agronomia E Coltivazioni ErbaceeScientific Opinion030104 developmental biologySettore AGR/11 - Entomologia Generale E ApplicataAnimal Science and ZoologyParasitologyGMO; cotton GHB614 x LLCotton25 x MON 15985; Regulation (EC) 1829/2003; Cry1Ac; Cry2Ab2; GUS; NPTII; 2mEPSPS; PATbusiness2mEPSPSPAT010606 plant biology & botanyFood Science
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The cytoprotective protein MANF promotes neuronal survival independently from its role as a GRP78 cofactor

2021

Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum (ER)-stress-regulated protein exhibiting cytoprotective properties through a poorly understood mechanism in various in vitro and in vivo models of neuronal and non-neuronal damage. Although initially characterized as a secreted neurotrophic factor for midbrain dopamine neurons, MANF has recently gained more interest for its intracellular role in regulating the ER homeostasis, including serving as a cofactor of the chaperone glucose-regulated protein 78 (GRP78). We aimed for a better understanding of the neuroprotective mechanisms of MANF. Here we show for the first time that MANF promotes the survival of …

0301 basic medicineBiFC bimolecular fluorescence complementationMST microscale thermophoresisPDIA1 protein disulfide isomerase family A member 1ApoptosisNEUROTROPHIC FACTOR MANFEndoplasmic ReticulumBiochemistryprotein-protein interactionMiceBimolecular fluorescence complementationUPR unfolded protein responseENDOPLASMIC-RETICULUM STRESSMesencephalonNeurotrophic factorsInsulin-Secreting CellsProtein Interaction MappingBINDINGCOMPREHENSIVE RESOURCEATF6unfolded protein response (UPR)PDIA6 protein disulfide isomerase family A member 6PPIs protein-protein interactionsEndoplasmic Reticulum Chaperone BiPHeat-Shock ProteinsNPTN neuroplastinbiologyChemistryapoptosisunfolded protein responsedopamine neurons3. Good healthCell biologyGDNF glial cell line–derived neurotrophic factorIRE1-ALPHASBD substrate-binding domainendoplasmic reticulum stressMANF mesencephalic astrocyte-derived neurotrophic factorTm tunicamycinneuroprotectionResearch ArticleProtein BindingSignal TransductionGRP78Protein Disulfide-Isomerase FamilyCell SurvivalTH tyrosine hydroxylasePrimary Cell CultureSCG superior cervical ganglionProtein Disulfide-IsomerasesIRE1 inositol-requiring enzyme 1ER-STRESSER endoplasmic reticulum03 medical and health sciencesohjelmoitunut solukuolemaC-MANF C-terminal domain of MANFCSPs chemical shift perturbationsAnimalsHumansHSP70 Heat-Shock ProteinsNerve Growth FactorsNBD nucleotide-binding domainNMR nuclear magnetic resonanceMolecular Biology030102 biochemistry & molecular biologyBIPATF6Dopaminergic NeuronsGene Expression ProfilingBinding proteinneuronal cell deathDISSOCIATIONCell BiologyNEI nucleotide exchange inhibitorEmbryo MammalianadenosiinitrifosfaattiATPhermosolutmesencephalic astrocyte-derived neurotrophic factorprotein–protein interactionPERK protein kinase RNA-like ER kinaseHEK293 Cells030104 developmental biologyGene Expression RegulationChaperone (protein)Tg thapsigarginbiology.proteinUnfolded protein responseAP-MS affinity purification mass spectrometry1182 Biochemistry cell and molecular biologyGFP-SH SH-tagged GFPendoplasmic reticulum stress (ER stress)DA dopaminemesencephalic astrocyte-derived neurotrophic factor (MANF)proteiinitNeuroplastin
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Nasal IgE in subjects with allergic and non-allergic rhinitis

2020

Abstract Purpose The prevalence of "ocal allergic rhinitis" within individuals suffering from perennial rhinitis remains uncertain, and patients usually are diagnosed with non-allergic rhinitis. The aim of this study was to evaluate the prevalence of a potential "local allergic rhinitis" in subjects suffering from non-allergic rhinitis in a non-selected group of young students. Methods 131 students (age 25.0 ± 5.1 years) with a possible allergic rhinitis and 25 non-allergic controls without rhinitis symptoms (age 22.0 ± 2.0 years) were recruited by public postings. 97 of 131 students with rhinitis were tested positive (≥3 mm) to prick testing with 17 frequent allergens at visit 1. Twenty-fo…

AllergyNon-allergic rhinitismedicine.medical_treatmentImmunoglobulin EAR + HDM allergic rhinitis with house dust mite allergyAllergic rhinitisHDM house dust miteNPT nasal provocation testsAR allergic rhinitis0302 clinical medicineISAAC International Study of Asthma and Allergies in Childhood questionnaireNARES non-allergic rhinitis with eosinophilia-syndromeMedicine and Health SciencesImmunology and Allergy030223 otorhinolaryngologyeducation.field_of_studybiologymedicine.diagnostic_testRadioallergosorbent testsIgE allergen-specific IgENon-allergicD1 Dermatophagoides pteronyssinusPREVALENCED2 Dermatophagoides farinaeLAR local allergic rhinitisPROVOCATION TESTSPulmonary and Respiratory Medicinelcsh:Immunologic diseases. AllergyLOCAL IGEImmunologyPopulationPATHOPHYSIOLOGYNon-allergic-rhinitisLocal allergic rhinitisGCP Good Clinical PracticeDIAGNOSISNasal provocation testArticleSECRETIONS03 medical and health sciencesFEV1/FVC ratiorhinitismedicineddc:610educationHouse dust mitebusiness.industryFEV1 forced expiratory volume in one secondRAST Radioallergosorbent Testbiology.organism_classificationmedicine.disease030228 respiratory systemHouse dust mite allergyPNIF peak nasal inspiratory flowImmunologyFVC forced vital capacitybiology.proteinbusinessSD standard deviationlcsh:RC581-607Local IgESPT skin prick testWorld Allergy Organization Journal
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Use of NPTWi in Fournier's gangrene

2013

Aim: Fournier's gangrene (FG) is defined as a fulminant form of infective necrotizing fascitis of the perineal, genital or perianal regions. Even with appropriate treatment approaches, mortality is high as 4 to 67%. There have been many advances in management of Fournier gangrene including use of vacuum assisted closure and hyperbaric oxygen therapy. Methods: a 72 y.o. male with swelling, redness, pain on palpating and necrosis of the penis, scrotum and perineal area including the perianal area, with diabetes mellitus type II, previous non Hodgkin lymphoma recent surgery for perianal fistula, was admitted in our clinic. Because of the extensive involvement of the anus and its sphincter was …

Fournier's Gangrene NPTWSettore MED/18 - Chirurgia Generale
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External drivers of EU differentiated cooperation: How change in the nuclear nonproliferation regime affects member states alignment

2023

Since its establishment, the Common Foreign and Security Policy (CFSP) has strived to increase convergence among EU member states. Yet, convergence remains elusive and scholars have started to explain the emergence of differentiated cooperation resulting from multiple internal EU crises. We posit that the convergence in the EU member states with respect to nuclear weapons has been fundamentally altered by the humanitarian turn to nuclear disarmament. This has led to a crystallization of differentiated subgroups among the member states, whose membership coincides with that of informal groupings active in the broader nuclear nonproliferation regime. Combining quantitative data on resolution s…

Political Science and International RelationsTPNWCFSPdifferentiationUNESCO::CIENCIAS JURÍDICAS Y DERECHONPTdifferentiated cooperationnuclear weapons
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Artrite o artropatia? Nuova mutazione del gene GNPTG in bambina con mucolipidosi IIIγ

2021

Settore MED/38 - Pediatria Generale E Specialisticamucolipidosi MLIIIγGNPTG
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EXOSOMES DERIVED FROM METASTATIC COLON CANCER CELLS TRANSFER MALIGNANT PHENOTYPIC TRAITS TO SURROUNDING CELLS: THEIR EMERGING ROLE IN TUMOR HETEROGEN…

2018

Several studies have clearly demonstrated that within a heterogeneous tumor mass the inter-clonal cooperation between metastatic and non-metastatic cells can facilitate the tumor progression. Recent accumulating evidence has highlighted that tumor-derived exosomes (TDEs) play a relevant role as mediator of the inter-clonal collaborative cooperation affecting the properties of both tumor and non-tumor component. In this context, our goal was to understand if exosomes derived from highly metastatic cells may influence the behaviour of less aggressive tumor cells and the properties of endothelium. We found that metastatic SW620 cells transfer through exosomes (SW620Exos) their round/amoeboid p…

Tumor-derived esosomeSettore BIO/13 - Biologia Applicataintratumor heterogeneityamoeboid phenptype
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