Search results for "Names"
showing 10 items of 6843 documents
A Sample Selection Model for Unit and Item Nonresponse in Cross-Sectional Surveys
2007
We consider a general sample selection model where unit and item nonresponse simultaneously affect a regression relationship of interest, and both types of nonresponse are potentially correlated. We estimate both parametric and semiparametric specifications of the model. The parametric specification assumes that the errors in the latent regression equations follow a trivariate Gaussian distribution. The semiparametric specification avoids distributional assumptions about the underlying regression errors. In our empirical application, we estimate Engel curves for consumption expenditure using data from the first wave of SHARE (Survey on Health, Aging and Retirement in Europe).
Abstract LB-295: Detection of oncogenic kinase mutations in circulating plasma DNA and correlation with clinical benefit in the phase III GRID study …
2013
Abstract Background: GRID is a phase III study for patients with advanced gastrointestinal stromal tumors (GIST) following failure of imatinib (I) and sunitinib (S) who were randomized to receive either the multikinase inhibitor regorafenib (R) or placebo (P). R demonstrated a highly significant improvement in progression-free survival compared with P (HR 0.27, p<0.0001). A preplanned retrospective biomarker analysis was conducted to assess GIST genotypes in GRID patients and to explore the possible impact of different driver oncogene mutations on clinical outcomes. Methods: DNA was isolated from archival tumor tissue and analyzed for KIT mutations via Sanger sequencing. The expectat…
Next-Generation Sequencing in Clinical Practice
2019
Abstract During the past few decades, Sanger sequencing represented the “gold standard” technique. In order to better define the mutational status of several genes at the same time, next-generation sequencing methodologies have been introduced in the molecular laboratory workflow. In the era of personalized medicine, this technological improvement plays a key role in the comprehensive molecular characterization of cancer patients in order to get a “tile” target therapy. For different cancer patients, different target therapies are available and different genes serve as clinical it relevant biomarkers. This chapter reviews the principal features of these novel technologies and their applicat…
Ighv Mutational Status By Deep Next Generation Sequencing Refines Ighv Sanger Sequencing Classification in Patients with Chronic Lymphocytic Leukaemia
2019
Introduction: Determination of the mutational status of rearranged immunoglobulin heavy chain variable (IgHV) genes in patients with Chronic Lymphocytic Leukaemia (CLL), is considered one of the most important prognostic factors: patients with unmutated IgHV (UM; ≥98% of identity to the germline) genes have a more aggressive disease course and develop more frequently unfavourable genetic deletions or mutations than patients with mutated IgHV (M; ≤98%). Mutational status, is currently determined by Sanger sequencing (Sseq) that allows the analysis of the major clone, however, international guidelines recommend caution in assigning mutational status in cases with "Borderline" IgHV identity (9…
The Lady from Basel's Barfüsserkirche - Molecular confirmation of the Mummy's identity through mitochondrial DNA of living relatives spanning 22 gene…
2021
Abstract The identity of the mummified Lady from the Barfusser Church in Basel, Switzerland has been unsolved for decades, despite the prominent location of the burial place in front of the choir screen. A recent multidisciplinary research approach came up with a possible candidate, Anna Catharina Bischoff who died in Basel in 1787 with an age of 69 years (1719–1787). To verify the identity of the mummy, genealogists of the Citizen Science Basel discovered three living individuals of the maternal lineage of two different family branches, separated from Anna Catharina Bischoff by up to 22 generations. In this study we compare the ancient mitochondrial DNA of the mummy recovered from a premol…
Regio- and stereoselective synthesis of spiro-heterocycles bearing the pyrazole scaffold via [3+2] cycloaddition reaction
2022
Abstract Herein we reported the utility of one-pot multicomponent based [3+2] cycloaddition reaction transformation to prepare a new two hybrids of spirooxindoles engrafted with pyrazole skeleton. Upon treatment of the electron-deficient olefins based pyrazole motif with in situ the generated azomethine ylides (AY) of sarcosine with the 6-chloro-isatin afforded spiroadducts. To enlighten the regio- and diastereo-selectivity of these spiroheterocycles, single crystal X-ray diffraction analysis was presented. Using Hirshfeld calculations, many short distance contacts such as O…H, Cl…H, N…H, H…C, C…C and Cl…S have a great impact on the molecular packing and the crystal stability of 8a and 8b. …
Direct interaction of the Usher syndrome 1G protein SANS and myomegalin in the retina
2011
Contains fulltext : 96822.pdf (Publisher’s version ) (Closed access) The human Usher syndrome (USH) is the most frequent cause of combined hereditary deaf-blindness. USH is genetically heterogeneous with at least 11 chromosomal loci assigned to 3 clinical types, USH1-3. We have previously demonstrated that all USH1 and 2 proteins in the eye and the inner ear are organized into protein networks by scaffold proteins. This has contributed essentially to our current understanding of the function of USH proteins and explains why defects in proteins of different families cause very similar phenotypes. We have previously shown that the USH1G protein SANS (scaffold protein containing ankyrin repeat…
On the behavior of a three-dimensional fractional viscoelastic constitutive model
2016
In this paper a three-dimensional isotropic fractional viscoelastic model is examined. It is shown that if different time scales for the volumetric and deviatoric components are assumed, the Poisson ratio is time varying function; in particular viscoelastic Poisson ratio may be obtained both increasing and decreasing with time. Moreover, it is shown that, from a theoretical point of view, one-dimensional fractional constitutive laws for normal stress and strain components are not correct to fit uniaxial experimental test, unless the time scale of deviatoric and volumetric are equal. Finally, the model is proved to satisfy correspondence principles also for the viscoelastic Poisson’s ratio a…
Relationship between resolution and accuracy of four intraoral scanners in complete-arch impressions
2018
Background The scanner does not measure the dental surface continually. Instead, it generates a point cloud, and these points are then joined to form the scanned object. This approximation will depend on the number of points generated (resolution), which can lead to low accuracy (trueness and precision) when fewer points are obtained. The purpose of this study is to determine the resolution of four intraoral digital imaging systems and to demonstrate the relationship between accuracy and resolution of the intraoral scanner in impressions of a complete dental arch. Material and methods A master cast of the complete maxillary arch was prepared with different dental preparations. Using four di…
Performance Analysis of M-DPSK Modulation over Fast-Hoyt Fading Channels under Non-Isotropic Scattering Conditions
2021
In this paper, we analyze the symbol error probability (SEP) performance of M-ary differential phase shift keying (M-DPSK) modulation schemes over frequency-flat fast-varying Hoyt multipath fading channels. Assuming general non-isotropic scattering conditions, we first derive a finite-range integral expression for the probability density function (PDF) of the phase difference between two non-isotropic Hoyt vectors perturbed by additive white Gaussian noise (AWGN). Based upon the theory of M-DPSK modulation and the obtained PDF formula, the SEP of M-DPSK and its corresponding asymptotic behavior in non-isotropic fast-Hoyt fading channels are derived. Specifically, a double semi-finite range …