Search results for "Native"

Validation and refinement of PROSASH model using the neutrophil‐to‐lymphocyte ratio in patients with HCC receiving sorafenib

2020

Triterpene Saponins from Cyclamen trocopteranthum

2010

Two new triterpene saponins ( 1- 2) together with three known saponins, deglucocyclamin I ( 3), cyclamin ( 4), and mirabilin ( 5), were isolated from the tubers of Cyclamen trocopteranthum. They were elucidated as 3 beta- O-{4- O-[3-hydroxyl-3-methylglutaryl]- beta-D-xylopyranosyl-(1 --> 2)- beta-D-glucopyranosyl-(1 --> 4)-[ beta-D-glucopyranosyl-(1 --> 2)]- alpha-L-arabinopyranosyl}-16 alpha-hydroxy-13 beta,28-epoxy-oleanan-30-al ( 1) and 3 beta- O-{4- O-[3-hydroxyl-3-methylglutaryl]- beta-D-xylopyranosyl-(1 --> 2)-[ beta-D-glucopyranosyl-(1 --> 6)]- beta-D-glucopyranosyl-(1 --> 4)-[ beta-D-glucopyranosyl-(1 --> 2)]- alpha-L-arabinopyranosyl}-16 alpha-hydroxy-20,30-lactone-olean-12-ene ( 2…

Metabolomics analysis and biological investigation of three Malvaceae plants

2019

Introduction: Metabolomics is a fast growing technology that has effectively contributed to many plant-related sciences and drug discovery. Objective: To use the non-targeted metabolomics approach to investigate the chemical profiles of three Malvaceae plants, namely Hibiscus mutabilis L. (Changing rose), H. schizopetalus (Dyer) Hook.f. (Coral Hibiscus), and Malvaviscus arboreus Cav. (Sleeping Hibiscus), along with evaluating their antioxidant and anti-infective potential. Methodology: Metabolic profiling was carried out using liquid chromatography coupled with high-resolution electrospray ionisation mass spectrometry (LC-HR-ESI-MS) for dereplication purposes. The chemical composition of th…

The SWI/SNF subunits BRG1 affects alternative splicing by changing RNA binding factor interactions with RNA

2019

AbstractBRG1 and BRM are ATPase core subunits of the human SWI/SNF chromatin remodelling complexes. The function of the SWI/SNF complexes in transcriptional initiation has been well studied, while a function in alternative splicing has only been studied for a few cases for BRM-containing SWI/SNF complexes. Here, we have expressed BRG1 in C33A cells, a BRG1 and BRM-deficient cell line, and we have analysed the effects on the transcriptome by RNA sequencing. We have shown that BRG1 expression affects the splicing of a subset of genes. For some, BRG1 expression favours exon inclusion and for others, exon skipping. Some of the changes in alternative splicing induced by BRG1 expression do not re…

Perspectives for Globalized Natural Medicines

2011

Natural medicines provide valuable resources to meet the requirements for global health care at affordable prices. Therefore, safety and efficacy need to be proven in a comparable manner to conventional drugs. Evidence-based natural and western medicine may merge to a “one-world medicine” for the sake of all patients in industrialized and developing countries. In the present review, we discuss strategies for (1) preservation of traditional knowledge on natural medicines, (2) sustainability of medicinal herbs and natural products, and (3) standardization and quality control. Novel technologies will impact research on natural medicines in the years to come, e.g. remote sensing to map medicina…

Civil and Commercial Mediation and National Courts: Towards a New Concept of Justice for the XXI Century?

2017

Modern societies are very much linked to the idea of litigation. The incessant increase in the level of litigation puts the whole judicial system under pressure because the volume of disputes brought before State courts increases, the proceedings are getting more and more lengthy and the costs incurred by the parties in such proceedings are also greatly increasing. This situation can impair the full implementation of the principle of access to justice for citizens.

General Report: New Developments in Civil and Commercial Mediation – Global Comparative Perspectives

2015

Modern societies are very much linked to the idea of litigation. The incessant increase in the level of litigation puts the whole judicial system under pressure because the volume of disputes brought before State courts increases, the proceedings become more and more lengthy and the costs incurred by the parties in such proceedings also greatly increase. This situation can impair the full implementation of the principle of access to justice for citizens.

A Comparison of Formulae for Calculating Cost-Efficient Sample Sizes of Case-Control Studies with an Internal Validation Scheme

2000

When a case-control study is planned to include an internal validation study, the sample size of the study and the proportion of validated observations has to be calculated. There are a variety of alternative methods to accomplish this. In this article some possible procedures will be compared in order to clarify whether considerable differences in the suggested optimal designs occur, dependent on the used method.

Response models for mixed binary and quantitative variables

1992

SUMMARY A number of special representations are considered for the joint distribution of qualitative, mostly binary, and quantitative variables. In addition to the conditional Gaussian models and to conditional Gaussian regression chain models some emphasis is placed on models derived from an underlying multivariate normal distribution and on models in which discrete probabilities are specified linearly in terms of unknown parameters. The possibilities for choosing between the models empirically are examined, as well as the testing of independence and conditional independence and the estimation of parameters. Often the testing of independence is exactly or nearly the same for a number of di…

Some links between conditional and coregionalized multivariate Gaussian Markov random fields

2020

Abstract Multivariate disease mapping models are attracting considerable attention. Many modeling proposals have been made in this area, which could be grouped into three large sets: coregionalization, multivariate conditional and univariate conditional models. In this work we establish some links between these three groups of proposals. Specifically, we explore the equivalence between the two conditional approaches and show that an important class of coregionalization models can be seen as a large subclass of the conditional approaches. Additionally, we propose an extension to the current set of coregionalization models with some new unexplored proposals. This extension is able to reproduc…