Search results for "Native"
showing 10 items of 1727 documents
In vivo discovery of a peptide that prevents CUG-RNA hairpin formation and reverses RNA toxicity in myotonic dystrophy models
2011
6 pages, 5 figures. PMID:21730182[PubMed] PMCID: PMC3141925[Available on 2012/1/19]
Correction: Daunorubicin reduces MBNL1 sequestration caused by CUG-repeat expansion and rescues cardiac dysfunctions in a Drosophila model of myotoni…
2018
ABSTRACT Myotonic dystrophy (DM) is a dominantly inherited neuromuscular disorder caused by expression of mutant myotonin-protein kinase (DMPK) transcripts containing expanded CUG repeats. Pathogenic DMPK RNA sequesters the muscleblind-like (MBNL) proteins, causing alterations in metabolism of various RNAs. Cardiac dysfunction represents the second most common cause of death in DM type 1 (DM1) patients. However, the contribution of MBNL sequestration in DM1 cardiac dysfunction is unclear. We overexpressed Muscleblind (Mbl), the Drosophila MBNL orthologue, in cardiomyocytes of DM1 model flies and observed a rescue of heart dysfunctions, which are characteristic of these model flies and resem…
Alternative Dispute Resolution Systems Across the European Union, Iceland and Norway
2014
Abstract Alternative dispute resolution schemes (ADR) have been developed differently across the EU. It is difficult to determine which of the countries have developed the most successful schemes. Therefore the aim of this article is to summarize different organizational aspects of ADR schemes across the EU, to determine similarities across different countries and to define them in specific systems. Defining these schemes in systems will not only help to evaluate and compare ADR schemes and their success between different countries but will help also professionals, governments and other stakeholders to develop more effective ADR schemes across the EU, Iceland and Norway.
Commento dell'art. 162 bis c.p. (Oblazione nelle contravvenzioni punite con pene alternative)
2012
Il lavoro riguarda le modalità operative dell'art. 162 bis, che appaiono differenti e aggravate rispetto all'art. 162 poiché l'attivazione del meccanismo è molto onerosa (a causa della necessaria pronta liquidità) e dunque in aperta contraddizione con la finalità deflattiva connaturata all'istituto. Altrettanto incompatibile con tale aspetto appare la subordinazione della concessione del beneficio alla valutazione discrezionale del giudice. Inoltre l'ambito di applicazione si presenta incerto con riferimento ad alcune categorie di reati sottratte alla depenalizzazione.
Komplementāras terapijas lietošana pacientiem, kas saņem pretvēža ārstēšanu - biežums, anamnēzes dokumentācija, un iespējamā mijiedarbība ar terapiju
2015
Ievads Pētījuma mērķis bija komplementārās un alternatīvās medicīnas (KAM) pielietošanas analīze plaušu vēža pacientu vidū, kas saņem standarta pretvēža terapiju; izvērtēt, kāds KAM veids ir vispopulārākais, kāda ir pacientu motivācija to izmantot, kā arī novērtēt ar KAM saistītās priekšrocības, toksicitātes un riskus. Metodes Pētījumā tika iekļauti izplatīta sīkšūnu un ne-sīkšūnu plaušu vēža pacienti, kas saņem paliatīvu ķīmijterapiju un/vai staru terapiju Paula Stradiņa Klīniskās Universitātes Slimnīcas Onkoloģijas klīnikā (Rīga). Dalībniekiem tika piedāvāta aprakstoša anketa latviešu un krievu valodās. Atbilžu precizēšanai tika izmantotas pus-strukturētas intervijas. Dati par toksicitāti…
The Acceptable Alternative Vehicle Fuel Price
2019
Historically, petroleum fuels have been the dominant fuel used for land transport. However, the growing need for sustainable national economics has urged us to incorporate more economical and ecological alternative vehicle fuels. The advantages and disadvantages of them complicate the decision-making process and compel us to develop adequate mathematical methods. Alternative fuel (compressed natural gas, liquefied petroleum gas, and ethanol fuel mixtures), the standard prices and their ratios were investigated. A mathematical model to determine a critical ratio between alternative and conventional fuel prices had already been developed. The results of this were investigated. The results sho…
Effects of Grammatical Structure of Compound Words on Word Recognition in Chinese
2018
Two lexical priming experiments were conducted to examine effects of grammatical structure of Chinese two-constituent compounds on their recognition. The target compound words conformed to two types of grammatical structure: subordinate and coordinative compounds. Subordinate compounds follow a structure where the first constituent modifies the second constituent (e.g., , meaning snowball); here the meaning of the second constituent (head) is modified by the first constituent (modifier). On the other hand, in coordinative compounds both constituents contribute equally to the word meaning (e.g., , wind and rain, meaning storm where the two constituent equally contribute to the word meaning).…
Gestión del cuerpo y planificación urbana: Desplazamiento de significado en la reivención de cuepos y ciudades
2020
Contemporary cities have administrations increasingly marked by urban planning guidelines that are guided by business and marketing and, to attract investments and tourists, implement strategies that aim to homogenize, spectacularize and control urban space. However, other experiences in the city potentially build new meaning to it, which would escape those strategically planned, creating alternative possibilities of uses, diverging from the way thar are predicted and proposed by the governmental power in their urban marketing strategies. The article discusses how the occupation of urban spaces by transvestites for prostitution may imply reflections on the role of norms of gender in the (re…
Towards sustainable mobility : Transformative scenarios for 2034
2022
Highlights • Increasing the share of walking and cycling is one of the building blocks of sustainable mobility transformation. • We organised an online Delphi survey for 30 walking and cycling experts during the first wave of COVID-19 pandemic. • Disaggregative Delphi analysis is elaborated based on the systemic restructuring of qualitative data. • Transport experts’ views of the future are described in the form of five walking and cycling scenarios up to 2034. • The results can be used for strategic transport planning and policy, and for identifying instruments for walking and cycling promotion in urban areas. Increasing the share of walking and cycling is one of the building blocks of sus…
Time-domain effective-one-body gravitational waveforms for coalescing compact binaries with nonprecessing spins, tides and self-spin effects
2018
We present TEOBResumS, a new effective-one-body (EOB) waveform model for nonprecessing (spin-aligned) and tidally interacting compact binaries.Spin-orbit and spin-spin effects are blended together by making use of the concept of centrifugal EOB radius. The point-mass sector through merger and ringdown is informed by numerical relativity (NR) simulations of binary black holes (BBH) computed with the SpEC and BAM codes. An improved, NR-based phenomenological description of the postmerger waveform is developed.The tidal sector of TEOBResumS describes the dynamics of neutron star binaries up to merger and incorporates a resummed attractive potential motivated by recent advances in the post-Newt…