Search results for "Native"
showing 10 items of 1727 documents
Direct electricity production from coconut oil - the electrooxidation of coconut oil in an acid electrolyte
2018
Supplying more and more energy is an essential task of today's energy industry. In the last few decades, in addition to traditional methods of energy production, alternative energy sources have been developing at a fast rate. One of the devices that can use these sources is the fuel cell (FC). FCs can be a power source of the future mainly due to their high efficiency, their low impact on the environment and the possibility of powering with different fuels. Most often, FCs are powered by hydrogen. However, issues with its cheap production and storage are the reasons for seeking new fuels for FCs. Yet it must be a fuel that will provide a zero or low emission level. One of these fuels can be…
Metabolism via arginase or nitric oxide synthase: two competing arginine pathways in macrophages
2014
Macrophages play a major role in the immune system, both as antimicrobial effector cells and as immunoregulatory cells, which induce, suppress or modulate adaptive immune responses. These key aspects of macrophage biology are fundamentally driven by the phenotype of macrophage arginine metabolism that is prevalent in an evolving or ongoing immune response. M1 macrophages express the enzyme nitric oxide synthase (NOS), which metabolizes arginine to nitric oxide (NO) and citrulline. NO can be metabolized to further downstream reactive nitrogen species, while citrulline might be reused for efficient NO synthesis via the citrulline-NO cycle. M2 macrophages are characterized by expression of the…
Pathophysiology of age-related diseases
2009
Abstract A Symposium regarding the Pathophysiology of Successful and Unsuccessful Ageing was held in Palermo, Italy on 7-8 April 2009. Three lectures from that Symposium by G. Campisi, L. Ginaldi and F. Licastro are here summarized. Ageing is a complex process which negatively impacts on the development of various bodily systems and its ability to function. A long life in a healthy, vigorous, youthful body has always been one of humanity's greatest dreams. Thus, a better understanding of the pathophysiology of age-related diseases is urgently required to improve our understanding of maintaining good health in the elderly and to program possible therapeutic intervention.
Vitamin D, allergies and asthma: focus on pediatric patients
2014
In recent years, the interest of the scientific world towards vitamin D gradually increased, and several studies have been conducted to dissect its possible role in modulating the development/course of allergic diseases. Also, Vitamin D supplementation has been assessed as a beneficial approach for treating allergies in some, but not all studies. We reviewed herein the available and relevant literature concerning the possible links between Vitamin D, its supplementation and allergic diseases. A literature search was made independently by the Authors, identifying articles for a narrative review. As per literature, Vitamin D plays a key role in calcium and phosphate metabolism, and it is esse…
Alternative UNC13D Promoter Encodes a Functional Munc13-4 Isoform Predominantly Expressed in Lymphocytes and Platelets
2020
Autosomal recessive mutations in genes required for cytotoxicity are causative of a life-threatening, early-onset hyperinflammatory syndrome termed familial hemophagocytic lymphohistiocytosis (FHL). Mutations in UNC13D cause FHL type 3. UNC13D encodes Munc13-4, a member of the Unc13 protein family which control SNARE complex formation and vesicle fusion. We have previously identified FHL3-associated mutations in the first intron of UNC13D which control transcription from an alternative transcriptional start site. Using isoform specific antibodies, we demonstrate that this alternative Munc13-4 isoform with a unique N-terminus is preferentially expressed in human lymphocytes and platelets, as…
Subject case alternation in negated existential, locative, and possessive clauses in Latvian
2018
[full article and abstract in English]
 The goal of this article is to analyse the alternation between the genitive and nominative cases in Latvian. As the alternation between genitive and nominative cases is possible in all clauses in which the verb būt ‘to be’ is used as an independent verb, this article examines existential, locative, and also possessive clauses, while also demonstrating that distinguishing these clause types is problematic for Latvian utilising the criteria given in the linguistic literature. Clauses containing the negative form of būt ‘to be’, i.e. nebūt, form the foundation of those selected for this study, as only in these sentences the genitive/nominative alter…
Artemisinin–Second Career as Anticancer Drug?
2015
Artemisinin represents a showcase example not only for the activity of medicinal herbs deriving from traditional chinese medicine, but for phytotherapy in general. Its isolation from Sweet Wormwood (qinhao, Artemisia annua L.) represents the starting point for an unprecedent success story in the treatment of malaria worldwide. Beyond the therapeutic value against Plasmodium parasites, it turned out in recent years that the bioactivity of artemisinin is not restricted to malaria. We and others found that this sesquiterpenoid also exerts profound anticancer activity in vitro and in vivo. Artemisinin-type drugs exert multi-factorial cellular and molecular actions in cancer cells. Ferrous iron …
Mediation for resolving family disputes
2016
Nowadays the understanding of the institute of marriage and its importance in the society has changed. Marriage is no longer assumed to be a commitment for a lifetime. As the principle of equality has replaced hierarchy as the guiding principle of family law it gave more grounds for family disputes and it became socially acceptable to leave marriages that are intolerable or merely unfulfilling. The aim of this article is to suggest an alternative dispute resolution method-mediation as a worthy option for resolving family conflicts.
Dictamen profesional sobre la fusión y escisión como extrategias alternativas en un grupo de sociedades
2021
This work is a professional, legal opinion which sets out two alternative strategies (merger by absorption and partial demerger) in order to bring together the different areas of activity of the various companies in a group of companies. The aim is to provide solutions to the questions raised by customers and, therefore, to set out clearly and simply the procedure to be followed in each of the strategies, weighing up the advantages and disadvantages from each of them
Suomalaiset nuoret verkkolehtien kuluttajina
2017
Digitalisaatio on muuttanut rajusti perinteistä lehdistöä sekä sisällöntuottami-sen ja jakelukanavien muuttumisen että uusien alan kilpailijoiden myötä. Samaan aikaan digitalisaation mahdollistamat muut ajanviettotavat ovat vähentäneet lukemista vapaa-ajalla, ja postmoderni, saturoitunut kulutusyhteiskunta on muuttanut kuluttajien arvomaailmaa ja kulutuskäyttäytymistä. Tämän tutkielman tarkoituksena oli selvittää nuorten kuluttajien asenteita verkkolehdistön tuotteisiin. Digitaaliajalla moniarvoiseen kulutusyhteiskuntaan syntyneet diginatiivit ovat tulevaisuuden kuluttajia. Heidän asenteidensa ja ostoaikeidensa tunteminen on tärkeää kehitettäessä digitaalisia tuotteita ja palveluita. Tutkie…