Search results for "Native"
showing 10 items of 1727 documents
Photosensitive Alternative Splicing of the Circadian Clock Gene timeless Is Population Specific in a Cold-Adapted Fly, Drosophila montana.
2018
To function properly, organisms must adjust their physiology, behavior and metabolism in response to a suite of varying environmental conditions. One of the central regulators of these changes is organisms' internal circadian clock, and recent evidence has suggested that the clock genes are also important in the regulation of seasonal adjustments. In particular, thermosensitive splicing of the core clock gene <i>timeless</i> in a cosmopolitan fly, <i>Drosophila melanogaster</i> , has implicated this gene to be involved in thermal adaptation. To further investigate this link we examined the splicing of <i>timeless</i> in a northern malt fly species, <i&…
Chemical constituents of the volatile oil of Murraya koenigii leaves
2004
Abstract The chemical composition of the volatile oil of the fresh leaves of Murraya koenigii growing wild in Dehra Dun was analyzed by gas chromatography-mass spectrometry. Thirty-four compounds consisting of 97.4% of the oil were identified. The major constituents identified were α-pinene (51.7%), sabinene (10.5%), β-pinene (9.8%), β-caryophyllene (5.5%), limonene (5.4%), bornyl acetate (1.8%), terpinen-4-ol (1.3%), γ-terpinene (1.2%) and α-humulene (1.2%).
Volatile constituents of flowering twig oil
2004
Summary The chemical constituents of the volatile oil of mature flowering twigs of wild Hyptis swaveolens growing widely in northern India were analyzed by gas chromatography–mass spectrometry. Forty one compounds consisting of 77.75% of the oil were identified. The major constituents of the oil were sabinene (14.18%), β-caryophyllene (12.52%), caryophyllene oxide (10.50%), abietatriene (6.42%), terpinen-4-ol (4.88%), limonene (4.42%), cis -sabinene hydrate (3.52%), spathulenol (3.14%), α-terpinolene (2.75%), β-pinene (2.42%), p -cymen-8-ol (1.76%), trans -sabinene hydrate (1.33%) and abietadiene (1.01%).
Nimbolide inhibits 2D and 3D prostate cancer cells migration, affects microtubules and angiogenesis and suppresses B-RAF/p.ERK-mediated in vivo tumor…
2021
Abstract Background Prostate cancer (PCa) is the most prominent malignancy among men worldwide. PCa cells have a high tendency to metastasize to various distant organs, and this activity is the main cause of PCa mortality. Nimbolide is a promising phytochemical constituent of neem Azadirachta indica (Meliaceae). Previous studies showed that nimbolide exhibited potent anticancer activity however, its role against PCa tumorigenesis has not been fully elucidated. Purpose Our work aims to explore the role of nimbolide in regulating the essential tumor-associated processes involved in the metastatic cascade in PCa cells. Study design Cytotoxicity assay, wound healing and spheroid invasion assays…
Subject case alternation in Latvian and Estonian existential clauses
2019
In Latvian and Estonian existential clauses, the subject’s case form alternates between nominative vs. genitive (in Latvian) and nominative vs. partitive (in Estonian). This article is a study of the case-alternation systems of existential clauses and related clause types, locative and possessive clauses in these languages. It includes a corpusbased analysis of Latvian existential clauses that is being compared with Estonian corpus-based findings on similar clause types in Estonian. *** Subjekti kaandevaheldus lati ja eesti keele eksistentsiaallausetes Nii eesti kui ka lati keeles esineb subjekti kaandevaheldust. Lati keeles saab subjekt olla lisaks nominatiivile ka genitiivis, eesti keeles…
Identical constituent compounds in German
2014
The status of identical constituent compounds (ICCs) (e.g. Künstler-Künstler, ‘artist-artist’) is discussed controversially in the morphological literature on German. In this paper, it is claimed that ICC formation is a productive word formation pattern in German. In the first part of the paper, I investigate the formal, semantic and pragmatic properties of ICCs in German. Based on this description, I discuss in more detail two conflicting claims about their meaning constitution: the ‘prototype reading claim’ and the ‘context-dependency claim’. I argue that ICCs do not behave differently, in principle, from canonical N+N compounds with respect to context-dependency. Based on a discussion o…
Anti-inflammatory activity of berenjenol and related compounds.
2008
Berenjenol ( 1), isolated from OXANDRA cf. XYLOPIOIDES (Annonaceae), was tested on two different experimental models of inflammation. The compound showed anti-inflammatory activity in the test of acute mouse ear edema induced by TPA (54 % inhibition, 1 μmol/ear) as well as in the test of subchronic inflammation induced by repeated application of TPA (57 % inhibition, 7 × 1 μmol/ear). Moreover, while it reduced the expression of both COX-2 (65 % inhibition at 50 μM) and iNOS (80 % inhibition at 50 μM), it was not active against TNF- α and IL-1 β in murine macrophages (RAW 264.7) stimulated with LPS. Structural modification of 1 gave two derivatives, berenjenol acetate ( 2) and 3-oxo-berenjen…
Phenolic Substances from Phagnalon rupestre Protect against 2,4,6-Trinitrochlorobenzene-Induced Contact Hypersensitivity
2011
2-isoprenylhydroquinone-1-glucoside (1), 3,5-dicaffeoylquinic acid (2), and 3,5-dicaffeoylquinic acid methyl ester (3), isolated from Phagnalon rupestre, improved the contact hypersensitivity response to 2,4,6-trinitrochlorobenzene in mice. These phenolics reduced ear swelling and IL-1β content by 50% 24 h after challenge; in addition, 2 inhibited tumor necrosis factor-α by 53%. All three compounds also reduced interleukin-2 content by 50% 72 h after challenge. Both 2 and 3 inhibited metalloproteinase-9 levels in the skin lesions by 66% and 41%, respectively, and lowered cyclooxygenase-2 expression by 44% and 49%, respectively, at 24 h. Moreover, 2 was effective against atopic dermatitis in…
Inhibition of NF-κB Activation and iNOS Induction by ent-Kaurane Diterpenoids in LPS-Stimulated RAW264.7 Murine Macrophages
2009
Xerophilusin A (1), xerophilusin B (2), longikaurin B (3), and xerophilusin F (4) from Isodon xerophylus inhibit LPS-induced NO production in RAW 264.7 macrophages, with IC(50) values of 0.60, 0.23, 0.44, and 0.67 muM, respectively, and they all inhibited mRNA production in these same cells. They decreased the luciferase activity in RAW 264.7 cells transiently transfected with the NF-kappaB-dependent luciferase reporter, with IC(50) values of 1.8, 0.7, 1.2, and 1.6 muM, respectively. Compounds 1-3 reduced NF-kappaB activation, with compound 4 showing no effect, but p65 translocation from the cytoplasm to the nucleus and the LPS-induced degradation of IkappaB were inhibited by all four test …
Budlein A from Viguiera robusta inhibits leukocyte-endothelial cell interactions, adhesion molecule expression and inflammatory mediators release
2009
Budlein A has been reported to exert some analgesic and anti-inflammatory properties. In this study, we have evaluated its effect on LPS-induced leukocyte recruitment in vivo and the mechanisms involved in its anti-inflammatory activity. In vivo, intravital videomicroscopy was used to determine the effects of budlein A on LPS-induced leukocyte-endothelial cell interactions in the murine cremasteric microcirculation. In vitro, the effects of budlein A on LPS-induced cytokine, chemokine and nitrites release, T-cell proliferative response as well as cell adhesion molecule expression (CAM) were evaluated. In vivo, intraperitoneal administration of budlein A (2.6 mM/kg) caused a significant redu…