Search results for "Neogene"
showing 10 items of 109 documents
Resting Energy expenditure in type 2 diabetic patients and the effect of insulin bolus
2014
Aims: Resting energy expenditure (REE) plays a critical role in the regulation of body weight, with important implications in type 2 diabetes (T2D). However, the relationships between REE and T2D have not been extensively evaluated. We compared REE in persons with diabetes and in persons without diabetes. We also investigated the acute effect of insulin on REE and venous lactate, the latter an indirect measure of neoglucogenetic activity. Methods: REE was measured using indirect calorimetry in 14 newly diagnosed, untreated T2D adults and in 14 non-diabetic age-, gender- and body mass index-matched persons. The REE and lactate venous concentrations were also measured in a subgroup of 5 T2D p…
Data from: Parallel diversifications of Cremastosperma and Mosannona (Annonaceae), tropical rainforest trees tracking Neogene upheaval of South Ameri…
2017
Much of the immense present day biological diversity of Neotropical rainforests originated from the Miocene onwards, a period of geological and ecological upheaval in South America. We assess the impact of the Andean orogeny, drainage of lake Pebas, and closure of the Panama Isthmus on two clades of tropical trees (Cremastosperma, c. 31 spp.; and Mosannona, c. 14 spp.; both Annonaceae). Phylogenetic inference revealed similar patterns of geographically restricted clades and molecular dating showed diversifications in the different areas occurred in parallel, with timing consistent with Andean vicariance and Central American geodispersal. Ecological niche modelling approaches show phylogenet…
Segmentation and differential post-rift uplift at the Angola margin as recorded by the transform-rifted Benguela and oblique-to-orthogonal-rifted Kwa…
2010
29 pages; International audience; We analyse tectonic and sedimentary field and subsurface data for the Angola onshore margin together with free-air gravity anomaly data for the offshore margin. This enables us to characterize the mode of synrift tectonism inherited from the Precambrian and its impact on the segmentation of the Angola margin. We illustrate that segmentation by the progressive transition from the Benguela transform-rifted margin segment to the oblique-rifted South Kwanza and orthogonal-rifted North Kwanza margin segments. The spatial variation in the intensity of post-rift uplift is demonstrated by the study of a set of geomorphic markers detected in the post-rift succession…
Der Einfluß von extremen Ausdauerbelastungen auf den Eiweißstoffwechsel des Menschen mit besonderer Berücksichtigung des Immunsystems
1985
In summer 1981, six long-distance runners covered a 1100-km-course across the Federal Republic of Germany within 20 days. Four of them were on a more or less ovo-lacto-vegetable and two a vegetarian diet. In spite of a high absolute but indeed low relative protein supply, a continuous decrease of the total protein content could be noticed in the serum. The alterations of the protein fractions corresponded to those of an acute-phase reaction. The Immunoglobulin-G and the Immunoglobulin-A content decreased continuously. The cortisol level was always above the norm, the insulin level always below. The glucagon level increased continuously in the course of the day. The urea-N-level moved around…
The Messinian stromatolites of the Sierra del Colmenar (Western Mediterranean): facies characterization and sedimentological interpretation
2018
A representative outcrop of the Messinian stromatolites belonging to the Terminal Carbonate Complex unit, from the northern sector of the Bajo Segura basin (Caja de Ahorros del Mediterraneo section, Sierra del Colmenar, SE Spain) has been studied. Here, we present a detailed analysis of the architecture, external morphology, and internal morphology in order to reconstruct the environmental and palaeoecological conditions for their growth. The stromatolites macrostructure consists of a continuously doming type morphology (build up and sheets areas).These developed close to the coast and acted as a palaeogeographic barrier, reducing physical stress, channeling the erosive effect of water and …
Influence of crustal thickening on arc magmatism:, Nevados de Payachata volcanic region, northern Chile
1993
Neogene through Pleistocene lava flows of the Nevados de Payachata region (lat 18°S) on the Altiplano of northern Chile fall into two discrete chemical groups defined by age and incompatible element concentrations. The Neogene suite (10.5-6.6 Ma) has trace element concentrations comparable to arc magmas erupted on thin crust in central Chile. Pleistocene lava flows (0.29-0 Ma) are enriched in incompatible elements relative to Neogene samples but have similar Sr, Nd, and Pb isotopic ratios. Incompatible element enrichment in mafic rocks reflects deep-crustal or subcrustal processes. Neogene volcanism in northern Chile immediately followed a period of intense crustal thickening. Uplift rates …
Distansescharella seguenzai Cipolla, 1921 (Bryozoa, Cheilostomata),nouvelles données morphologiques et écologiques tirées de spécimens fossiles (Mioc…
1989
The cribrimorph Distansescharella seguenzai Cipolla,,1921, described from the Pliocene of Sicily has been rediscovered in fossil deposits (Messinian of Western Algeria, and Lower Pliocene of Calabria, Southern Italy) and in Recent Mediterranean material (Straits of Gibraltar, Alboran Sea, Gulf of Tripoli). Its morphology is demonstrated by SEM study of living specimens. In spite of some differences with the type-species of Distansescharella D'Orbigny revealed by examination of its neotype, the generic status of D. seguenzai is confirmed. An ecological analysis of the Recent and fossil assemblages including D. seguenzai is made by considering the zoarial growth forms and the potential habita…
Evidence for hypothalamic ketone bodies sensing: impact on food intake and peripheral metabolic responses in mice
2016
Monocarboxylates have been implicated in the control of energy homeostasis. Among them, the putative role of ketone bodies produced notably during high-fat diet (HFD) has not been thoroughly explored. In this study, we aimed to determine the impact of a specific rise in cerebral ketone bodies on food intake and energy homeostasis regulation. A carotid infusion of ketone bodies was performed on mice to stimulate sensitive brain areas for 6 or 12 h. At each time point, food intake and different markers of energy homeostasis were analyzed to reveal the consequences of cerebral increase in ketone body level detection. First, an increase in food intake appeared over a 12-h period of brain keton…
Hypothalamic Apelin/Reactive Oxygen Species Signaling Controls Hepatic Glucose Metabolism in the Onset of Diabetes
2014
Aims: We have previously demonstrated that central apelin is implicated in the control of peripheral glycemia, and its action depends on nutritional (fast versus fed) and physiological (normal versus diabetic) states. An intracerebroventricular (icv) injection of a high dose of apelin, similar to that observed in obese/diabetic mice, increase fasted glycemia, suggesting (i) that apelin contributes to the establishment of a diabetic state, and (ii) the existence of a hypothalamic to liver axis. Using pharmacological, genetic, and nutritional approaches, we aim at unraveling this system of regulation by identifying the hypothalamic molecular actors that trigger the apelin effect on liver gluc…
Link between Intestinal CD36 Ligand Binding and Satiety Induced by a High Protein Diet in Mice
2012
International audience; CD36 is a ubiquitous membrane glycoprotein that binds long-chain fatty acids. The presence of a functional CD36 is required for the induction of satiety by a lipid load and its role as a lipid receptor driving cellular signal has recently been demonstrated. Our project aimed to further explore the role of intestinal CD36 in the regulation of food intake. Duodenal infusions of vehicle or sulfo-N-succinimidyl-oleate (SSO) was performed prior to acute infusions of saline or Intralipid (IL) in mice. Infusion of minute quantities of IL induced a decrease in food intake (FI) compared to saline. Infusion of SSO had the same effect but no additive inhibitory effect was obser…