Search results for "Nerva"
showing 10 items of 110 documents
Executive summary of the joint position paper on renal denervation of the Cardiovascular and Interventional Radiological Society of Europe and the Eu…
2016
Renal denervation (RDN) was reported as a novel exciting treatment for resistant hypertension in 2009. An initial randomized trial supported its efficacy and the technique gained rapid acceptance across the globe. However, a subsequent large blinded, sham arm randomized trial conducted in the USA (to gain Food and Drug Administration approval) failed to achieve its primary efficacy end point in reducing office blood pressure at 6 months. Published in 2014 this trial received both widespread praise and criticism. RDN has effectively stopped out with clinical trials pending further evidence. This joint consensus document representing the European Society of Hypertension and the Cardiovascular…
The Effects of Renal Denervation on Renal Hemodynamics and Renal Vasculature in a Porcine Model
2015
Rationale Recently, the efficacy of renal denervation (RDN) has been debated. It is discussed whether RDN is able to adequately target the renal nerves. Objective We aimed to investigate how effective RDN was by means of functional hemodynamic measurements and nerve damage on histology. Methods and Results We performed hemodynamic measurements in both renal arteries of healthy pigs using a Doppler flow and pressure wire. Subsequently unilateral denervation was performed, followed by repeated bilateral hemodynamic measurements. Pigs were terminated directly after RDN or were followed for 3 weeks or 3 months after the procedure. After termination, both treated and control arteries were prepar…
Effects of intermittent high frequency electrical stimulation on denervated EDL muscle of rabbit.
1990
This study was performed to determine whether electrical stimulation can retard denervation-induced changes. The denervated extensor digitorum longus of the rabbit, a fast-twitch muscle, was stimulated at a rate mimicking its motoneuron firing pattern. The 100-Hz stimulation given intermittently subjected the muscle to a low mean total daily frequency of 1.6 Hz. Four weeks of stimulation resulted in no effect upon the denervated stimulated muscle. This stimulation protocol, therefore, is unable to substitute for the lost neuronal influence of the nerve. The muscle contralateral to the stimulated side showed physiological changes making it unsuitable to serve as a control.
An innervated retroauricular skin flap for total earlobule reconstruction.
2003
In this article, the authors describe a technique for total earlobule reconstruction in a patient who underwent earlobule excision for basal cell carcinoma. The reconstruction was by means of an innervated retroauricular skin flap, folded double. The flap presented preserved skin sensitivity over all the reconstructed area, which is compromised by those techniques using a cranially or medially based flap which lead to the reconstruction of an insensible earlobule. This is a very important aspect of this technique, especially for those who wear pendant earrings, since a non-sensitive lobule would be more vulnerable to traumas causing laceration. In addition, it allows a good aesthetic result…
BDNF is essentially required for the early postnatal survival of nociceptors
2010
AbstractNeurotrophins promote the survival of specific types of neurons during development and ensure proper maintenance and function of mature responsive neurons. Significant effects of BDNF (Brain-Derived Neurotrophic Factor) on pain physiology have been reported but the contribution of this neurotrophin to the development of nociceptors has not been investigated. We present evidence that BDNF is required for the survival of a significant fraction of peptidergic and non-peptidergic nociceptors in dorsal root ganglia (DRG) postnatally. Bdnf homozygous mutant mice lose approximately half of all nociceptive neurons during the first 2 weeks of life and adult heterozygotes exhibit hypoalgesia …
Renal artery denervation for treating resistant hypertension: Definition of the disease, patient selection and description of the procedure
2012
Arterial hypertension is responsible for a significant burden of cardiovascular morbidity and mortality, worldwide. Although several rational and integrated pharmacological strategies are available, the control of high blood pressure still remains largely unsatisfactory. Failure to achieve effective blood pressure control in treated hypertensive patients may have a substantial impact on individual global cardiovascular risk, since it significantly increases the risk of developing hypertension-related macrovascular and microvascular complications. Arterial hypertension is arbitrarily defined as 'resistant' or 'refractory' when the recommended blood pressure goals (clinic blood pressure below…
ESH position paper: renal denervation - an interventional therapy of resistant hypertension
2012
Experts from the European Society of Hypertension prepared this position paper in order to summarize current evidence, unmet needs and practical recommendations on the application of percutaneous transluminal ablation of renal nerves [renal denervation (RDN)] as a novel therapeutic strategy for the treatment of resistant hypertension. The sympathetic nervous activation to the kidney and the sensory afferent signals to the central nervous system represent the targets of RND. Clinical studies have documented that catheter-based RDN decreases both efferent sympathetic and afferent sensory nerve traffic leading to clinically meaningful systolic and diastolic blood pressure (BP) reductions in pa…
Perineirālas deksametazona ievades izvērtējums pēc vienmomenta n.ischiadicus blokā
2019
Pētījuma aktualitāte: Apakšstilba vai pēdas pēcoperācijas sāpju mazināšanai multimodālas analgēzijas ietvaros tiek veikta n.ischiadicus blokāde. Tā kā lokālo anestētiķu darbības ilgums ir samērā īss, tiek veikti pētījumi par deksametazonu kā adjuvantu blokādes ilguma pagarināšanai. Mēs vēlamies Latvijā izpētīt deksametazona iedarbību uz n.ischiadicus bloka analgētiskās darbības ilgumu. Mērķis: Samazināt sāpes pacientiem pēc apakšstilba vai pēdas operācijām, pagarinot n.ischiadicus bloka analgētisko darbību, izmantojot deksametazonu kā adjuvantu. Metodes: Prospektīvs, randomizēts pētījums. Visiem pētījuma pacientiem tika veikta spinālā anestēzija un n.ischiadicus bloks ar bupivakaīnu. Pacien…
Maskuliinisen saagan päätös : mediaskandaalin mekanismi ja merkitys yhteiskunnan valtasuhteiden ja kipupisteiden osoittajana
2011
Pitkän poliittisen uransa huipulla ollut ulkoministeri Ilkka Kanerva joutui vuonna 2008 eroamaan skandaalin seurauksena. Kanervan kohtaloksi koituivat sadat, eroottiselle tanssijalle lähetetyt tekstiviestit. Audin myyntijohtaja Esko Kiesi taas menetti työnsä vuotta myöhemmin, kun hänen sovinistisiksi tulkitut kommenttinsa naisista herättivät suuttumusta erityisesti Internetin keskustelupalstoilla. Yhteistä näille tapahtumille oli se, että molemmissa tapauksissa medialla oli suuri rooli kohujen käynnistämisessä. Useat tutkijat ovatkin sitä mieltä, että skandaalit viestivät poliittisen kulttuurin murroksesta Suomessa, poliitikkojen ja toimittajien valtasuhteiden muutoksesta sekä politiikan me…
Reinervación cardiaca tras trasplante cardiaco : valoración clínica, funcional e isotópica en el primer año tras trasplante
2013
El trasplante cardiaco supone un estado de denervación cardiaca completa con implicaciones fisiológicas, clínicas y funcionales. En los últimos años, diversos grupos han demostrado mediante diversas técnicas la existencia de un fenómeno de reinervación cardiaca tras el trasplante que podría tener implicaciones funcionales. El presente trabajo doctoral pretende concretar la existencia de este fenómeno de reinervación durante los primeros doce meses tras la cirugía. Además, plantea un enfoque multidisciplinar para el estudio de la inervación cardiaca incluyendo herramientas de medicina nuclear, pruebas de esfuerzo, valoración de calidad de vida y parámetros electrocardiográficos relacionados …