Search results for "Network analysis"
showing 10 items of 230 documents
Inferring slowly-changing dynamic gene-regulatory networks
2015
Dynamic gene-regulatory networks are complex since the interaction patterns between their components mean that it is impossible to study parts of the network in separation. This holistic character of gene-regulatory networks poses a real challenge to any type of modelling. Graphical models are a class of models that connect the network with a conditional independence relationships between random variables. By interpreting these random variables as gene activities and the conditional independence relationships as functional non-relatedness, graphical models have been used to describe gene-regulatory networks. Whereas the literature has been focused on static networks, most time-course experi…
Hub-Centered Gene Network Reconstruction Using Automatic Relevance Determination
2012
Network inference deals with the reconstruction of biological networks from experimental data. A variety of different reverse engineering techniques are available; they differ in the underlying assumptions and mathematical models used. One common problem for all approaches stems from the complexity of the task, due to the combinatorial explosion of different network topologies for increasing network size. To handle this problem, constraints are frequently used, for example on the node degree, number of edges, or constraints on regulation functions between network components. We propose to exploit topological considerations in the inference of gene regulatory networks. Such systems are often…
Beyond the Family and the Household: Occupational Family Networks
2009
Although families and kinship have been studied extensively from a historical perspective, less attention has been paid to their significance and role in the formation of local social networks.This study makes use of extensive Finnish records of godparentage to map local networks to analyze the factors (kinship, work relations, neighborhood, friendship) that influenced their formation. It argues that, in the context of a closed industrial community, occupation and kinship were the major cornerstones of these networks. Only after work-related inequality was slowly eliminated in the early twentieth century did kinship begin to gain ground as the main influencing factor.
Paths of local development: Two technological districts face-to-face
2009
In this paper we compare the two hi-tech districts of Catania and Genoa, which are within the same national context and economic sector, with the aim of explaining their different choices (the promotion of external investments, in the first case, and fostering of the development of small businesses, in the second case) in the light of the local economic structure and the role played by political, economic, and educational institutions. Local actors have differently influenced the development of a professional community through the interpersonal networks of entrepreneurs and the performance obtained by local small businesses. While Catania has experienced a higher and more rapid growth, deve…
Place Attachment and Its Consequence for Landscape-Scale Management and Readiness to Participate: Social Network Complexity in the Post-Soviet Rural …
2019
This paper uses the tripartite place attachment framework to examine six rural parishes across Estonia and Latvia. Existing analyses/frameworks on participatory processes often neglect the complexity of relationships that rural residents have to their local environments. From a qualitative analysis of face-to-face, semi-structured interviews with case study area inhabitants (23 interviews in Estonia and 27 in Latvia), we depict varying degrees of attachment of individuals to each other and to the place in which they live and their readiness to participate in terms of willingness and ability to participate in a landscape-scale management process. Attachment to the local area was strongest wh…
Measuring Globalization of International Trade: Theory and Evidence
2009
Measuring globalization requires a Standard of Perfect International Integration as a benchmark that a single world space would reach under conditions of geographic neutrality in international trade. We define this standard and present indicators for openness, connectedness and integration, for each specific economy, and for the world economy. We apply our indicators to data on trade flows for 59 countries for the 1967-2004 period. Results show that trade integration is higher than what traditional openness indicators suggest. Several economies find high levels of integration, but the low degree of openness in some large economies jeopardizes the progress of globalization. © 2008 Elsevier L…
Transcriptional changes through menstrual cycle reveal a global transcriptional derepression underlying the molecular mechanism involved in the windo…
2021
The human endometrium is a dynamic tissue that only is receptive to host the embryo during a brief time in the middle secretory phase, called the window of implantation (WOI). Despite its importance, regulation of the menstrual cycle remains incompletely understood. The aim of this study was to characterize the gene cooperation and regulation of menstrual cycle progression, to dissect the molecular complexity underlying acquisition of endometrial receptivity for a successful pregnancy, and to provide the scientific community with detailed gene co-expression information throughout the menstrual cycle on a user-friendly web-tool database. A retrospective gene co-expression analysis was perfor…
A simple unsynchronized two‐end algorithm for faults location and identification in electrical distribution systems
2012
PurposeThe purpose of this paper is to identify a new and simple two‐end algorithm for fault location identification and characterization, in electrical distribution systems.Design/methodology/approachThe developed diagnostic algorithm is based on a simple model of the network using a lumped parameters representation.FindingsTest results have proved the approach to be efficient, allowing a precise fault identification and location while not requiring synchronized measures from the two ends.Research limitations/implicationsThere is a need for measurement systems at all MV/LV substations.Practical implicationsApplicability with limited investments is not possible where metering systems are no…
Beyond the “ivory tower”. Comparing academic and non-academic knowledge on social entrepreneurship
2021
The increasing relevance of societal challenges has recently brought social entrepreneurship to the fore due to its capacity to leverage entrepreneurial processes to achieve social value while ensuring profits. In this study, we apply an experimental research method to analyse the concept of social entrepreneurship comprehensively. More specifically, we develop bibliometric analysis and web crawling techniques to gather information related to social entrepreneurship from Scopus and Wikipedia. We conduct a comparative network analysis of social entrepreneurship’s conceptual structure at academic and non-academic levels. This analysis has been performed considering scientific articles’ keywor…
Uso de indicadores bibliométricos para el análisis de temas emergentes y su evolución: spin-offs como caso de estudio
2018
[ES] Las spin-offs constituyen una de las áreas de investigación más atractivas, ya que están asociadas con fenómenos como el emprendimiento, la innovación y la transferencia del conocimiento. El presente estudio muestra que la selección y el uso de indicadores bibliométricos permite identificar y caracterizar el desarrollo y la difusión de temas de investigación emergentes como el analizado. Los principales aspectos observados en relación con el desarrollo de la investigación sobre las spin-offs son que se produce un auge en el número de publicaciones después de un largo período de latencia y la marcada naturaleza multidisciplinar del área. El presente enfoque ha analizado la evolución de …