Search results for "Network topology"
showing 10 items of 192 documents
A demagnetization circuit for forward converters
2009
This paper presents a demagnetization circuit able to operate the forward converter with an higher efficiency and with a wider input range. In particular, by the means of few added components, the magnetizing energy and the leakage one are continuously recovered, and the transformer reset and the primary mosfet OFF voltage clamp to the input, both under steady state and transient operations, are provided. The reduced voltage stress allows the converter to operate with a duty extended to unity over the typical 70% limit of the Active Clamp topology, with smaller output inductance, better converter dynamics and wider input range. Furthermore, thanks to this technique, by employing a duty appr…
SPtsAnalysis: a high-throughput super-resolution single particle trajectory analysis to reconstruct organelle dynamics and membrane re-organization
2021
AbstractSuper-resolution imaging can generate thousands of single-particle trajectories. These data can potentially reconstruct subcellular organization and dynamics, as well as measure disease-linked changes. However, computational methods that can derive quantitative information from such massive datasets are currently lacking. Here we present data analysis and algorithms that are broadly applicable to reveal local binding and trafficking interactions and organization of dynamic sub-cellular sites. We applied this analysis to the endoplasmic reticulum and neuronal membrane. The method is based on spatio-temporal time window segmentation that explores data at multiple levels and detects th…
Dynamics of gene regulatory networks and their dependence on network topology and quantitative parameters – the case of phage λ
2019
Background Gene regulatory networks can be modelled in various ways depending on the level of detail required and biological questions addressed. One of the earliest formalisms used for modeling is a Boolean network, although these models cannot describe most temporal aspects of a biological system. Differential equation models have also been used to model gene regulatory networks, but these frameworks tend to be too detailed for large models and many quantitative parameters might not be deducible in practice. Hybrid models bridge the gap between these two model classes – these are useful when concentration changes are important while the information about precise concentrations and binding…
On achieving intelligent traffic-aware consolidation of virtual machines in a data center using Learning Automata
2018
Unlike the computational mechanisms of the past many decades, that involved individual (extremely powerful) computers or clusters of machines, cloud computing (CC) is becoming increasingly pertinent and popular. Computing resources such as CPU and storage are becoming cheaper, and the servers themselves are becoming more powerful. This enables clouds to host more virtual machines (VMs). A natural consequence ofthis is that many modern-day data centers experience very high internaltraffic within the data centers themselves. This is, of course, due to the occurrence of servers that belong to the same tenant, communicating between themselves. The problem is accentuated when the VM deployment t…
A novel methodology for large-scale phylogeny partition
2011
Understanding the determinants of virus transmission is a fundamental step for effective design of screening and intervention strategies to control viral epidemics. Phylogenetic analysis can be a valid approach for the identification of transmission chains, and very-large data sets can be analysed through parallel computation. Here we propose and validate a new methodology for the partition of large-scale phylogenies and the inference of transmission clusters. This approach, on the basis of a depth-first search algorithm, conjugates the evaluation of node reliability, tree topology and patristic distance analysis. The method has been applied to identify transmission clusters of a phylogeny …
Structural analyses of a hypothetical minimal metabolism
2007
By integrating data from comparative genomics and large-scale deletion studies, we previously proposed a minimal gene set comprising 206 protein-coding genes. To evaluate the consistency of the metabolism encoded by such a minimal genome, we have carried out a series of computational analyses. Firstly, the topology of the minimal metabolism was compared with that of the reconstructed networks from natural bacterial genomes. Secondly, the robustness of the metabolic network was evaluated by simulated mutagenesis and, finally, the stoichiometric consistency was assessed by automatically deriving the steady-state solutions from the reaction set. The results indicated that the proposed minimal …
Use of geomorphological units to improve drainage network extraction from a DEM
1999
Abstract Drainage networks are one of the main elements characterizing basins, and network topology and geometry form the basis of many hydrological and geomorphological models ( eg Geomorphological Unitary Hydrograph). The identification and manual delineation of channel networks from maps or aerial photographs requires much time and effort. In the last two decades, algorithms and procedures for automated extraction of drainage networks from digital elevation data have been developed and implemented in many specialized software applications. Nevertheless, automatically delineated channel networks do not always show close agreement with manually delineated networks. This paper describes a c…
Deployment of a WLCG network monitoring infrastructure based on the perfSONAR-PS technology
2014
The WLCG infrastructure moved from a very rigid network topology, based on the MONARC model, to a more relaxed system, where data movement between regions or countries does not necessarily need to involve T1 centres. While this evolution brought obvious advantages, especially in terms of flexibility for the LHC experiment's data management systems, it also opened the question of how to monitor the increasing number of possible network paths, in order to provide a global reliable network service. The perfSONAR network monitoring system has been evaluated and agreed as a proper solution to cover the WLCG network monitoring use cases: it allows WLCG to plan and execute latency and bandwidth te…
Capacity and Energy-Consumption Optimization for the Cluster-Tree Topology in IEEE 802.15.4
2011
International audience; 802.15.4 proposes to use a cluster-tree hierar- chy to organize the transmissions in Wireless Sensor Networks. In this letter, we propose a framework to analyze formally the capacity and the energy consumption of this structure. We derive a Mixed Integer Linear Programming (MILP) formulation to obtain a topology compliant with the standard. This formulation provides the optimal solution for the network capacity: this con- stitutes an upper bound for any distributed algorithms permitting to construct a cluster-tree. This framework can also be used to evaluate the capacity and to compare quantitatively different cluster-tree algorithms.
Gene connectivity and enzyme evolution in the human metabolic network
2019
[Background] Determining the factors involved in the likelihood of a gene being under adaptive selection is still a challenging goal in Evolutionary Biology. Here, we perform an evolutionary analysis of the human metabolic genes to explore the associations between network structure and the presence and strength of natural selection in the genes whose products are involved in metabolism. Purifying and positive selection are estimated at interspecific (among mammals) and intraspecific (among human populations) levels, and the connections between enzymatic reactions are differentiated between incoming (in-degree) and outgoing (out-degree) links.