6533b83afe1ef96bd12a6f6f

RESEARCH PRODUCT

Gene connectivity and enzyme evolution in the human metabolic network

Begoña DobonJaume BertranpetitLudovica MontanucciHafid LaayouniJuli Peretó

subject

ImmunologyPopulationMetabolic networkComputational biologyBiologyGeneral Biochemistry Genetics and Molecular BiologyEvolution Molecular03 medical and health sciencesNegative selectionDegreePurifying selectionAnimalsHumansSelection Geneticeducationlcsh:QH301-705.5GeneEcology Evolution Behavior and Systematics030304 developmental biologyMammalschemistry.chemical_classification0303 health scienceseducation.field_of_studyConnectivityNatural selectionNetwork topologyResearchApplied Mathematics030302 biochemistry & molecular biologyEnzymesPositive selectionFixation (population genetics)EnzymeMetabolismlcsh:Biology (General)chemistryModeling and SimulationGeneral Agricultural and Biological SciencesSelective sweepMetabolic Networks and Pathways

description

[Background] Determining the factors involved in the likelihood of a gene being under adaptive selection is still a challenging goal in Evolutionary Biology. Here, we perform an evolutionary analysis of the human metabolic genes to explore the associations between network structure and the presence and strength of natural selection in the genes whose products are involved in metabolism. Purifying and positive selection are estimated at interspecific (among mammals) and intraspecific (among human populations) levels, and the connections between enzymatic reactions are differentiated between incoming (in-degree) and outgoing (out-degree) links.

yearjournalcountryeditionlanguage
2019-09-03
10.1186/s13062-019-0248-7http://hdl.handle.net/10261/206076