Search results for "Neurologi"

CHANGING PERSPECTIVE ON PERCEPTION PHYSIOLOGY: CAN YOU REALLY SEE WHAT IS HAPPENING?

2018

Perception is a complex, neural mechanism that requires organization and interpretation of input meaning and it has been a key topic in medicine, neuroscience and philosophy for centuries. Gestalt psychology proposed that the underlying mechanism is a constructive process that depends on both input of stimuli and the sensory-motor state of the agent. The Bayesian Brain hypothesis reframed it as probabilistic inference of previous beliefs, which are revised to accommodate new information. The Predictive Coding Theory proposes that this process is implemented through a top-down cascade of cortical predictions of lower level input and the concurrent propagation of a bottom-up prediction error …

Computer-assisted cognitive remediation for Parkinson’s disease

2012

Questions and controversies in the study of time-varying functional connectivity in resting fMRI.

2020

The brain is a complex, multiscale dynamical system composed of many interacting regions. Knowledge of the spatiotemporal organization of these interactions is critical for establishing a solid understanding of the brain’s functional architecture and the relationship between neural dynamics and cognition in health and disease. The possibility of studying these dynamics through careful analysis of neuroimaging data has catalyzed substantial interest in methods that estimate time-resolved fluctuations in functional connectivity (often referred to as “dynamic” or time-varying functional connectivity; TVFC). At the same time, debates have emerged regarding the application of TVFC analyses to re…

Huntingtin mediates dendritic transport of β-actin mRNA in rat neurons

2011

Transport of mRNAs to diverse neuronal locations via RNA granules serves an important function in regulating protein synthesis within restricted sub-cellular domains. We recently detected the Huntington's disease protein huntingtin (Htt) in dendritic RNA granules; however, the functional significance of this localization is not known. Here we report that Htt and the huntingtin-associated protein 1 (HAP1) are co-localized with the microtubule motor proteins, the KIF5A kinesin and dynein, during dendritic transport of β-actin mRNA. Live cell imaging demonstrated that β-actin mRNA is associated with Htt, HAP1, and dynein intermediate chain in cultured neurons. Reduction in the levels of Htt, H…

Genetic features of neuroblastic tumors associated with opsoclonus-myoclonus syndrome opens up the possibility for detection in peripheral blood

2016

Opsoclonus–myoclonus syndrome (OMS) is a rare paraneoplastic, postinfectious, or parainfectious or idiopathic acute neurological syndrome in children and adults. OMS is characterized by involuntary...

TRANSCRANICAL MAGNETIC STIMULATION IN COCAINE ADDICTION:PRELIMINARY FINDINGS

2014

Drug addiction is a brain disease which leads to profound disturbances in an individual’s behaviour. In spite of the progress made in the understanding of the neurobiological mechanisms underlying addiction, expectations from a therapeutic point of view have not been satisfying. Given the modest efficacy of therapeutic tools available, Transcranial Magnetic Stimulation (TMS) seems to be a promising “non-pharmacologic” aid in various neuropathologies including addiction which is characterized by a decrease of dopaminergic activity (DA). Thus, ‘restoring’ pre-pathology DA activity may yield clinical benefits in addicts. In particular, it has been reported that TMS reduces the craving for coca…

The diagnosis of multiple sclerosis: pinpointing the concept of "no better explanation"

2014

Reduced Admissions for Cerebrovascular Events during COVID-19 Outbreak in Italy

2020

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Prevalence of lumbosacral radiculopathy in two Sicilian municipalities

2009

Objectives - As part of a door-to-door survey of neurologic diseases, we investigated the prevalence of lumbosacral radiculopathy (LR) in two Sicilian municipalities (N = 14,540, as of November 1, 1987). Material & methods - During phase 1, we administered a brief screening instrument to subjects in the study population. In phase 2, study neurologists using specified diagnostic criteria investigated those subjects who screened positive. Our case finding was restricted to subjects who manifested symptoms of LR in the six months preceding the prevalence day. Results - We found 143 subjects affected by LR (112 definite, 31 possible) yielding a crude prevalence of 9.8 cases per 1,000 population…

Memory for time intervals is impaired in left hemi-Parkinson patients.

2004

The basal ganglia have been proposed as one of the neural correlates of timekeeping functions. Both encoding and memory retrieval components for time perception are impaired in Parkinson's disease (PD). The aim of our study was to investigate in hemi-Parkinsonian patients the existence of a specific alteration in memory for time depending on the affected side, to better understand the contribution of the left or right basal ganglia circuits in different components of time perception. Right and left hemi-PD patients performed a time reproduction task in which they were required to reproduce in the same session short (5 s) and long (15 s) time intervals, in off- and on-therapy condition. Whil…