Search results for "Neurologi"
showing 10 items of 1189 documents
Lessons Learned from the German Registry for Acute Aortic Dissection Type A (GERAADA) and Expectations for the Future
2014
The German Registry for Acute Aortic Dissection type A (GERAADA) is a prospective observational clinical multicenter registry that was launched in 2006. With more than 2,500 patients included from over 50 recruiting centers it is—to our knowledge—the most representative register for acute aortic dissection type A (AADA) currently available. We examined mortality and post-operative events as well as the influence of various pre- and intraoperative factors on these endpoints. Among patients registered, 30-day mortality is 15.9 %. 13.4 % of patients experienced postoperatively a new neurological deficit and a total of 10.5 % of patients suffered from permanent neurological impairment 30 days a…
Apoe genotype influences the biological effects of AChe inhibitors on platelet APP metabolism
2000
Gender-related effect of clinical and genetic variables on the cognitive impairment in multiple sclerosis
2004
BACKGROUND: Cognitive impairment may occur at any time during the course of multiple sclerosis (MS), and it is often a major cause of disability in patients with the disease. The APOE-epsilon4 allele is the major known genetic risk factor for late onset familial and sporadic Alzheimer's Disease (AD), and it seems to be implicated in cognitive decline in normal elderly persons. OBJECTIVE: To investigate the clinical and genetic variables that can be associated with the cognitive decline in patients with MS. METHODS: Five-hundred and three patients with clinically definite MS underwent a battery of neuropsychological tests and, according to the number of failed tests, were divided into cognit…
Haptoglobin interacts with apolipoprotein E and beta-amyloid and influences their crosstalk.
2014
Beta-amyloid accumulation in brain is a driving force for Alzheimer's disease pathogenesis. Apolipoprotein E (ApoE) represents a critical player in beta-amyloid homeostasis, but its role in disease progression is controversial. We previously reported that the acute-phase protein haptoglobin binds ApoE and impairs its function in cholesterol homeostasis. The major aims of this study were to characterize the binding of haptoglobin to beta-amyloid, and to evaluate whether haptoglobin affects ApoE binding to beta-amyloid. Haptoglobin is here reported to form a complex with beta-amyloid as shown by immunoblotting experiments with purified proteins, or by its immunoprecipitation in brain tissues …
No association between Glu298Asp endothelial nitric oxide synthase polymorphism and Italian sporadic Alzheimer's disease.
2003
A great amount of evidence suggests that neuroinflammation may be a major pathogenetic mechanism in the pathophysiology of sporadic Alzheimer's Disease (sAD). Recently, polymorphisms in the endothelial nitric oxide synthase (NOS3) gene have been associated to late onset Alzheimer's Disease in a British population. However, other groups failed to replicate this finding in Asiatic and Caucasian populations. We conducted a case-control study including a clinically well-defined group of 149 sAD patients and 149 age and sex matched controls to test the association between NOS3 Glu298Asp polymorphism and sAD in an ethnically homogenous Italian population. All subjects were genotyped at NOS3 and a…
APOE epsilon variation in multiple sclerosis susceptibility and disease severity: some answers
2006
Background: Previous studies have examined the role of APOE variation in multiple sclerosis (MS), but have lacked the statistical power to detect modest genetic influences on risk and disease severity. The meta- and pooled analyses presented here utilize the largest collection, to date, of MS cases, controls, and families genotyped for the APOE epsilon polymorphism. Methods: Studies of MS and APOE were identified by searches of PubMed, Biosis, Web of Science, Cochrane Review, and Embase. When possible, authors were contacted for individual genotype data. Meta-analyses of MS case-control data and family-based analyses were performed to assess the association of APOE epsilon genotype with dis…
Isolated, Subtle Neurological Abnormalities in Mild Cognitive Impairment Types.
2019
Isolated, subtle neurological abnormalities (ISNA) are commonly seen in aging and have been related to cerebral small vessel disease (SVD) and subcortical atrophy in neurologically and cognitively healthy aging subjects.To investigate the frequency of ISNA in different mild cognitive impairment (MCI) types and to evaluate for each MCI type, the cross-sectional relation between ISNA and white matter hyperintensities (WMH), lacunes, caudate atrophy, and ventricular enlargement.One thousand two hundred fifty subjects with different MCI types were included in the analysis and underwent brain magnetic resonance imaging. WMHs were assessed through two visual rating scales. Lacunes were also rated…
Modeling the insect mushroom bodies: application to a delayed match-to-sample task.
2013
Despite their small brains, insects show advanced capabilities in learning and task solving. Flies, honeybees and ants are becoming a reference point in neuroscience and a main source of inspiration for autonomous robot design issues and control algorithms. In particular, honeybees demonstrate to be able to autonomously abstract complex associations and apply them in tasks involving different sensory modalities within the insect brain. Mushroom Bodies (MBs) are worthy of primary attention for understanding memory and learning functions in insects. In fact, even if their main role regards olfactory conditioning, they are involved in many behavioral achievements and learning capabilities, as …
Methodological advances in brain connectivity
2012
Determining how distinct neurons or brain regions are connected and communicate with each other is a crucial point in neuroscience, as it allows to investigate how the functional integration of specialized neural populations enables the emergence of coherent cognitive and behavioral states. The general concept of brain connectivity encompasses different aspects: structural connectivity is related to the description of anatomical pathways and synaptic connections; functional connectivity investigates statistical dependencies between spatially separated brain regions; effective connectivity refers to models aimed at elucidating driver-response relationships. The study of these different modes…