Search results for "Neurologia"
showing 10 items of 730 documents
PECULIARE EVOLUZIONE DELLA SEMEIOTICA NEURORADIOLOGICA DI UN CASO DI MALATTIA DEMIELINIZZANTE CON LESIONI PSEUDOTUMORALI
2013
SCOPO DEL LAVORO Presentiamo un caso di una paziente di 24 anni che giunge alla nostra attenzione per la comparsa di disartria come quadro clinico d’esordio di una forma aggressiva di malattia demielinizzante di cui si valuta l’atipica evoluzione neuroradiologica delle lesioni pseudotumorali che la caratterizzano e le possibili diagnosi differenziali. MATERIALI E METODI La paziente dopo una prima valutazione in PS è stata sottoposta a TC encefalo, ricoverata presso l’U.O. di Neurologia, sottoposta a controlli RM seriati (anche con tecniche avanzate); durante la degenza è stata inoltre effettuata una biopsia stereotassica. RISULTATI La TC ha rilevato almeno tre lesioni ipodense: a sinistra…
Sequenziamento temporale ed elaborazione neurale: una prospettiva psicofisiologica
2011
ALS-RELATED FUS PROTEIN IS MISLOCALIZED TO CYTOPLASM AND RECRUITED INTO STRESS GRANULES IN FIBROBLASTS OF ASYMPTOMATIC FUS P525L MUTATION CARRIERS
Symptoms onset in Amyotrophic Lateral Sclerosis (ALS) occur when over 70% of motor neurons is already lost, suggesting a relatively long pre-symptomatic phase. The description of several genes linked to ALS (e.g., SOD1, FUS, TARDP, C9orf72) has now allowed identification of pre-symptomatic carriers. These pre-symptomatic (or even preclinical) carriers can be followed up with the aim to identify the very early clinical disease-related changes or a valuable biomarker. These efforts seem at present the best approach for the implementation of an early symptomatic therapy or for the disease prevention. In this work, we studied the expression of FUS protein in cultured skin fibroblasts from pre-s…
The role of circulating and exosomal miRNAs as biomarkers of drug-resistant epilepsy
Epilepsy is estimated to affect about 65 million individuals worldwide, with up to 30 percent of drug-resistant patients who do not have remission despite appropriate therapy with antiepileptic drugs (AEDs). Therefore, it is important to distinguish drug-resistant epilepsy early in the course of disease to start a specific therapeutical approach as soon as possible. Recently circulating miRNAs have been proposed as promising biomarkers for different neurodegenerative disorders, including epilepsy. MiRNAs are a class of small non-coding RNA that regulate gene expression at a post-transcriptional level. The regulatory mechanisms controlling translation of mRNA transcripts represents to date a…
Effect of RNS60 in amyotrophic lateral sclerosis: a phase II multicentre, randomized, double-blind, placebo-controlled trial
2022
Background and purpose: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with limited treatment options. RNS60 is an immunomodulatory and neuroprotective investigational product that has shown efficacy in animal models of ALS and other neurodegenerative diseases. Its administration has been safe and well tolerated in ALS subjects in previous early phase trials. Methods: This was a phase II, multicentre, randomized, double-blind, placebo-controlled, parallel-group trial. Participants diagnosed with definite, probable or probable laboratory-supported ALS were assigned to receive RNS60 or placebo administered for 24 weeks intravenously (375 ml) once a week and via nebul…
Terapia trans-cranica ad ultrasuoni focalizzati guidati da Risonanza Magnetica: studio retrospettivo di semeiotica neuroradiologica intra-operatoria
2019
SCOPO DEL LAVORO: Valutare retrospettivamente le caratteristiche di semeiotica neuroradiologica delle lesioni indotte in pazienti sottoposti a talamotomia unilaterale del nucleo Vim mediante l’utilizzo di un sistema trans-cranico ad ultrasuoni focalizzati guidati da RM (tcMRgFUS). MATERIALI E METODI: Cinquanta pazienti sono stati sottoposti a talamotomia mediante tcMRgFUS per tremore essenziale refrattario a terapia medica (n = 39) o per tremore in malattia di Parkinson (n = 11). Esaminando sequenze FRFSE T2-pesate (2mm, no gap) acquisite sia intra-operatoriamente che nel successivo follow-up RM a 48h, è stata valutata la presenza e le dimensioni delle aree lesionali concentriche precedente…
Terapia trans-cranica ad ultrasuoni focalizzati guidati da Risonanza Magnetica (tcMRgFUS) utilizzando un sistema integrato con uno scanner RM da 1.5T…
2018
Scopo Negli ultimi anni la terapia transcranica ad ultrasuoni focalizzati guidati da risonanza magnetica (tcMRgFUS) per il trattamento di disordini neurologici quali il tremore essenziale (ET) e il Parkinson tremorigeno (PD) è stata effettuata utilizzando esclusivamente scanner RM da 3T. Presentiamo i risultati ottenuti con il primo sistema tcMRgFUS mai integrato con uno scanner RM da 1.5T. Materiali e metodi 23 pazienti (19 ET; 4 PD) sono stati selezionati per essere sottoposti a tcMRgFUS (talamotomia monolaterale; target: nucleo ventrale intermedio, VIM). I pazienti arruolati sono stati valutati prima del trattamento e 2 giorni dopo. L'efficacia del trattamento è stata valutata utilizzand…
Students’ Perceptions of Instructional Rubrics in Neurological Physical Therapy and Their Effects on Students’ Engagement and Course Satisfaction
2021
One of the main challenges faced by physical therapy (PT) students is to learn the practical skills involved in neurological physical therapy (PT). To help them to acquire these skills, a set of rubrics were designed for formative purposes. This paper presents the process followed in the creation of these rubrics and their application in the classroom, noting that students perceived them as valid, reliable, and highly useful for learning. The perception of the validity and usefulness of the rubrics has different closely related dimensions, showing homogeneous values across the students´ sociodemographic and educational variables, with the exception of dedication to studying, which showed a …