Search results for "Neurology"
showing 10 items of 11123 documents
Author response: Dopamine neurons drive fear extinction learning by signaling the omission of expected aversive outcomes
2018
Barrel Cortex Function Special Issue Editorial
2018
Overview of the History of the Cranial Nerves: From Galen to the 21st Century
2018
Throughout history the description and classification of the cranial nerves has been linked to the development and characteristics of anatomy and the role that it played as a tool in providing rationality to medicine, together with social, cultural, religious, and philosophical factors. Anatomists were interested in the cranial nerves, but they disagreed on their number and their paths. We can divide the history of the cranial nerves into three different periods: the first, early or macroscopic period; the second or microscopic period; and the third period or ontogenesis and genoarchitecture. The main aim of this article is to show how the description and knowledge of the cranial nerves wer…
Building Robustness into Translational Research
2020
AbstractNonclinical studies form the basis for the decision whether to take a therapeutic candidate into the clinic. These studies need to exhibit translational robustness for both ethical and economic reasons. Key findings confirmed in multiple species have a greater chance to also occur in humans. Given the heterogeneity of patient populations, preclinical studies or at least programs comprising multiple studies need to reflect such heterogeneity, e.g., regarding strains, sex, age, and comorbidities of experimental animals. However, introducing such heterogeneity requires larger studies/programs to maintain statistical power in the face of greater variability. In addition to classic sourc…
L’emploi de méthodes mathématiques pour détecter la présence de potentiels évoqués dans le coma : un aide ou un fardeau ?
2016
Un des defis majeurs auxquels sont confrontes les services de reanimation est de pouvoir predire precisement et precocement vers quel etat evoluera la conscience des patients dans le coma pour anoxie cerebrale. Afin d’obtenir des indices directs sur l’etat cerebral fonctionnel, l’emploi des potentiels evoques est recommande, et notamment l’enregistrement de la negativite de discordance (MMN). La MMN est une onde cerebrale apparaissant entre 100 et 200 ms apres l’apparition d’un nouveau stimulus dans une sequence de stimuli identique et sa presence est un signe fort de recuperation. Le standard dans la determination de la presence d’une onde MMN en pratique clinique est l’analyse visuelle pa…
La alteración de la mielina en la enfermedad de Alexander
2018
Resumen: Introducción: La enfermedad de Alexander (AxD) es una leucodistrofia. Su base patológica, junto a la pérdida de mielina, es la aparición de los cuerpos de Rosenthal, que son inclusiones citoplasmáticas en células astrocitarias. Mutaciones en el gen que codifica la GFAP se han identificado como una base genética para AxD. Sin embargo, no se conoce el mecanismo por el cual estas variantes producen la enfermedad. Desarrollo: La hipótesis más extendida es que AxD se desarrolla por un mecanismo por ganancia de función debido al incremento de GFAP. Sin embargo, este mecanismo no explica la pérdida mielínica, dado que los modelos experimentales que expresan GFAP normal o mutada no generan…
Reply from Mari Carmen Gomez-Cabrera and Jose Viña
2017
Il neonato con gli occhi socchiusi. La displasia ectodermica legata al gene TP63
2021
An Italian female newborn presented with cleft palate, erythroderma, desquamations, skin erosions, ankyloblepharon filiforme adnatum, broad nasal root, short philtrum, thin vermillion border, maxillary hypoplasia, microstomia, microglossia, cupped ears, hypoplasia of the distal phalange of left index, widely spaced nipples and polythelia. The hallmarks of ankyloblepharon-ectodermal dysplasia-clefting syndrome (or Hay-Wells syndrome) as well as persistent scalp erosions led to exclude more frequent skin disorders like congenital ichthyosiform erythroderma or epidermolysis bullosa and to diagnose Hay-Wells syndrome by genetic analysis. Target sequencing of the tumour protein p63 (TP63) gene r…
Dénutrition protéino-énergétique extrême : un concept mal connu en EHPAD
2017
Resume Il existe une forme particuliere de denutrition proteino-energetique (DPE) en geriatrie : la denutrition proteino-energetique extreme (DPEE). Certaines personnes entrent en etablissement d’hebergement pour personnes âgees dependantes (EHPAD) en situation de DPEE, c’est-a-dire avec un indice de masse corporelle (IMC) inferieur a 18,5 kg/m 2 . Par sa similitude avec le syndrome de renutrition inapproprie (SRI) ou refeeding syndrome , la DPEE n’est pas toujours identifiee comme une situation a risque. Or, une approche nutritionnelle ordinaire peut avoir des consequences deleteres. Nous presentons une mise au point bibliographique sur les risques de renutrition inadapte de la DPEE de la …
Extensive osteonecrosis of the maxilla caused by bisphosphonates: Report of a rare case
2019
Bisphosphonates are drugs indicated for the treatment of bone metabolic diseases or malignant hypercalcemia. They are generally well-tolerated drugs, however, recent reports have described osteonecrosis of the jaw bones as a potentially serious complication related to the long-term use of these drugs. We report a case of severe osteonecrosis in a 52-years-old white woman that was taking bisphosphonates (zoledronic acid and alendronate) for the management of osteoporosis. Following a long exposure to these drugs and after being subjected to multiples exodontias, developed bisphosphonate-related osteonecrosis of the jaw compromising the whole maxilla and that extended toward the base of skull…