Search results for "Neuron"

Influencia de la estimulación eléctrica del Núcleo Incertus sobre la actividad del circuito hipocampo-amígdala- prefrontal

2023

El núcleo incertus (NI), sensible al estrés y parte del sistema reticular activador ascendente, proyecta a las principales estructuras implicadas en la generación y modulación del ritmo theta hipocámpico, por lo que ha sido relacionado con la respuesta al estrés y procesos cognitivos. El hipocampo, implicado en el aprendizaje y la memoria, presenta un gradiente dorsoventral conectivo y funcional. La región dorsal participa en la navegación espacial y las porciones ventral e intermedia se han asociado con respuestas emocionales y con el valor motivacional. Estudios previos han demostrado el papel regulador del NI sobre la actividad theta de hipocampo dorsal, pero se desconoce su papel sobre …

Bases physiologiques de la satiété et de la digestion

2015

Neuronal Growth and Behavioral Alterations in Mice Deficient for the Psychiatric Disease-Associated Negr1 Gene

2018

Neuronal growth regulator 1 (NEGR1), a member of the immunoglobulin superfamily cell adhesion molecule subgroup IgLON, has been implicated in neuronal growth and connectivity. In addition, genetic variants in or near the NEGR1 locus have been associated with obesity and more recently with learning difficulties, intellectual disability and psychiatric disorders. However, experimental evidence is lacking to support a possible link between NEGR1, neuronal growth and behavioral abnormalities. Initial expression analysis of NEGR1 mRNA in C57Bl/6 wildtype (WT) mice by in situ hybridization demonstrated marked expression in the entorhinal cortex (EC) and dentate granule cells. In co-cultures of co…

Voluntary Imitation in Alzheimer’s Disease Patients

2016

International audience; Although Alzheimer's disease (AD) primarily manifests as cognitive deficits, the implicit sensorimotor processes that underlie social interactions, such as automatic imitation, seem to be preserved in mild and moderate stages of the disease, as is the ability to communicate with other persons. Nevertheless, when AD patients face more challenging tasks, which do not rely on automatic processes but on explicit voluntary mechanisms and require the patient to pay attention to external events, the cognitive deficits resulting from the disease might negatively affect patients' behavior. The aim of the present study was to investigate whether voluntary motor imitation, i.e.…

Behavioral Restriction Determines Left Attentional Bias: Preliminary Evidences From COVID-19 Lockdown

2021

International audience; During the COVID-19 lockdown, individuals were forced to remain at home, hence severely limiting the interaction within environmental stimuli, reducing the cognitive load placed on spatial competences. The effects of the behavioral restriction on cognition have been little examined. The present study is aimed at analyzing the effects of lockdown on executive function prominently involved in adapting behavior to new environmental demands. We analyze non-verbal fluency abilities, as indirectly providing a measure of cognitive flexibility to react to spatial changes. Sixteen students (mean age 20.75; SD 1.34), evaluated before the start of the lockdown (T1) in a battery…

Neuronal Growth and Behavioral Alterations in Mice Deficient for the Psychiatric Disease-Associated

2017

Neuronal growth regulator 1 (NEGR1), a member of the immunoglobulin superfamily cell adhesion molecule subgroup IgLON, has been implicated in neuronal growth and connectivity. In addition, genetic variants in or near the NEGR1 locus have been associated with obesity and more recently with learning difficulties, intellectual disability and psychiatric disorders. However, experimental evidence is lacking to support a possible link between NEGR1, neuronal growth and behavioral abnormalities. Initial expression analysis of NEGR1 mRNA in C57Bl/6 wildtype (WT) mice by in situ hybridization demonstrated marked expression in the entorhinal cortex (EC) and dentate granule cells. In co-cultures of co…

Psychologie cognitive

2007

International audience; Les ouvrages de la collection Lexifac Psychologie exposent, sous forme de fiches, les thèmes majeurs figurant aux programmes des premiers cycles universitaires. Leur présentation claire et structurée vise un triple objectif : fournir une synthèse complète du cours, faisant ressortir les notions essentielles et leur articulation ; permettre une préparation efficace aux examens en donnant aux étudiants les moyens de rassembler leurs connaissances ; favoriser une consultation rapide sur un point précis. La psychologie cognitive est étudiée à travers deux tomes : le premier porte sur l'historique, les concepts fondamentaux et les thèmes essentiels (langage, mémoire, rais…

Perception of quality and complexity in wine and their links to varietal typicality: An investigation involving Pinot noir wine and professional tast…

2020

International audience; Quality and complexity are abstract terms employed frequently to describe a wine's overall attributes. In the present study, we investigated: (i) attributes driving wine professionals' judgments of quality and complexity in Pinot noir wines; (ii) the relation between these two abstract concepts; and (iii) association of each concept with varietal typicality. Twenty-two wine professionals evaluated 18 New Zealand Pinot noir wines in both clear and opaque glassware via two sensory tasks, a descriptive rating task and an 8-attribute, perceived complexity questionnaire. Sensory data were associated with wine UV-spectrophotometry colour measures to aid interpretation of t…

Fabry Disease With Concomitant Lewy Body Disease

2019

AbstractAlthough Gaucher disease can be accompanied by Lewy pathology (LP) and extrapyramidal symptoms, it is unknown if LP exists in Fabry disease (FD), another progressive multisystem lysosomal storage disorder. We aimed to elucidate the distribution patterns of FD-related inclusions and LP in the brain of a 58-year-old cognitively unimpaired male FD patient suffering from predominant hypokinesia. Immunohistochemistry (CD77, α-synuclein, collagen IV) and neuropathological staging were performed on 100-µm sections. Tissue from the enteric or peripheral nervous system was unavailable. As controls, a second cognitively unimpaired 50-year-old male FD patient without LP or motor symptoms and 3…

Computing temporal sequences associated with dynamic patterns on the C. elegans connectome

2021

AbstractUnderstanding how the structural connectivity of a network constrains the dynamics it is able to support is a very active and open area of research. We simulated the plausible dynamics resulting from the known C. elegans connectome using a recent model and theoretical analysis that computes the dynamics of neurobiological networks by focusing on how local interactions among connected neurons give rise to the global dynamics in an emergent way, independent of the biophysical or molecular details of the cells themselves. We studied the dynamics which resulted from stimulating a chemosensory neuron (ASEL) in a known feeding circuit, both in isolation and embedded in the full connectome…