Search results for "Nippostrongylus"
showing 5 items of 5 documents
First survey on zoonotic helminthosis in urban brown rats (Rattus norvegicus) in Spain and associated public health considerations.
2018
Abstract The brown rat, Rattus norvegicus, with a worldwide distribution, is the most commensal species among synanthropic rodents, since its main habitat, in urban as well as in rural areas, is always linked to humans. Therefore, people living in close proximity to rodent populations can be exposed to infection. Whereas bacteria and viruses are the best known rat-associated zoonoses in urban environments, the role of brown rats as reservoirs for helminth parasites and the associated risk for humans are less well known. Specifically, this role has not been analyzed in Spain to date. A total of 100 R. norvegicus trapped in the sewage system (n = 85), and parks (n = 15) of Barcelona was exami…
Influenza A virus infection inhibits the efficient recruitment of Th2 cells into the airways and the development of airway eosinophilia.
2003
Abstract Most infections with respiratory viruses induce Th1 responses characterized by the generation of Th1 and CD8+ T cells secreting IFN-γ, which in turn have been shown to inhibit the development of Th2 cells. Therefore, it could be expected that respiratory viral infections mediate protection against asthma. However, the opposite seems to be true, because viral infections are often associated with the exacerbation of asthma. For this reason, we investigated what effect an influenza A (flu) virus infection has on the development of asthma. We found that flu infection 1, 3, 6, or 9 wk before allergen airway challenge resulted in a strong suppression of allergen-induced airway eosinophil…
Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring
2019
Mothers transfer immune cells via breastfeeding to provide offspring with long-term protection from parasitic infection.
Inhibition of Lymphocyte Proliferation during Parasitic Infection with Nippostrongylus Brasiliensis
1979
It is now well established that parasitic infections can lead to the production of high titers of IgE anti parasitic antibodies in experimental animals and in man (1,2). One of the best studied experimental systems involves the ability of the nematode parasite Nippostrongylus brasiliensis (N.B.) to stimulate a high titer reaginic antibody response to worm antigens in the rat. These studies were extended by the reports of Orr and Blair that parasitic infections can cause non specific proliferation of IgE antibody response against antigens unrelated to those of the parasite (3). The amplification of an already existing IgE antibody response can be induced before infection by inoculating the a…
IL-27 enhances the lymphocyte mediated innate resistance to primary hookworm infection in the lungs
2020
AbstractInterleukin-27 (IL-27) is a heterodimeric cytokine of the IL-12 family, formed by non-covalent association of the promiscuous EBI3 subunit and selective p28 subunit. IL-27 is produced by mononuclear phagocytes and unfolds pleiotropic immune-modulatory functions through high affinity ligation to IL-27 receptor alpha (IL-27RA). While IL-27 is known to contribute to immunity and to end inflammation following numerous types of infections, its relevance for host defense against multicellular parasites is still poorly defined. Here, we investigated the role of IL-27 during infection with the soil-transmitted hookworm, Nippostrongylus brasiliensis, in its early intrapulmonary life cycle. I…