6533b83afe1ef96bd12a702f

RESEARCH PRODUCT

Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring

Dunja MrjdenValérie F. J. QuesniauxWilliam G. C. HorsnellWilliam G. C. HorsnellWilliam G. C. HorsnellMatthew DarbyFrank BrombacherFrank BrombacherFrank BrombacherBenjamin G DewalsDelphine SeddaKatherine A. SmithKatherine A. SmithMarion RolotDonald D. NyangahuKai-michael ToellnerClaire MackowiakBernhard RyffelAlisha ChettyHeather B. JaspanHeather B. JaspanAri WaismanAdam F. Cunningham

subject

Long lastingCD4-Positive T-LymphocytesMaleCellular immunityOffspring[SDV]Life Sciences [q-bio]animal diseasesImmunologyAntibodies Helminthchemical and pharmacologic phenomenaReceptors Cell SurfaceBiology03 medical and health sciences0302 clinical medicineImmune systemTh2 CellsNursingImmunityPregnancymedicineHelminthsAnimalsLactationImprinting (psychology)Research Articles030304 developmental biologyStrongylida Infections0303 health sciencesPregnancyB-LymphocytesImmunity CellularMice Inbred BALB CMultidisciplinarySciAdv r-articlesbiochemical phenomena metabolism and nutritionmedicine.disease3. Good healthAnimals SucklingMice Inbred C57BLbacteriaFemaleNippostrongylusImmunity Maternally-Acquired030215 immunologyResearch Article

description

Mothers transfer immune cells via breastfeeding to provide offspring with long-term protection from parasitic infection.

yearjournalcountryeditionlanguage
2019-05-01Science Advances
10.1126/sciadv.aav3058http://europepmc.org/articles/PMC6587632