Search results for "Nitrogen Oxides"

showing 9 items of 29 documents

Restricting Magnetic Interaction Pathways in Polyoxometalate Salts of Cationic Nitronyl Nitroxide Free Radicals

2004

Abstract : Salts 1 and 2 that combine the [W 6 O 19 ] 2- Lindqvist anion with the cationic nitronyl nitroxide (NN) free radicals p -MepyNN + and n Bu 3 NCH 2 NN + , respectively, have been synthesized and their structural and magnetic properties have been studied. Keywords: Nitroxide radicals, polyoxometalates, magnetism. Introduction Ferromagnetism based on purely organic materials has raised a lot of interest during the last decade [1]. Most of the studies have been performed with nitronyl nitroxide (NN) radicals due to their persistence, stability and ease of functionalization [2]. Bulk ferromagnetism in these compounds arises from ferromagnetic interactions between open-shell molecules …

Nitroxide mediated radical polymerizationFree RadicalsMagnetismPharmaceutical ScienceCrystallography X-RayPhotochemistryCrystal engineeringArticleNitroxide radicalsAnalytical Chemistrylcsh:QD241-441Magneticslcsh:Organic chemistryCationsDrug DiscoveryAntiferromagnetismMoleculepolyoxometalatesPhysical and Theoretical Chemistrymagnetism.ChemistryOrganic ChemistryIntermolecular forceTemperatureTungsten CompoundsCrystallographyFerromagnetismChemistry (miscellaneous)PolyoxometalateMolecular MedicineNitrogen OxidesDimerizationMolecules
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Heparin–polynitroxides: Synthesis and preliminary evaluation as cardiovascular EPR/MR imaging probes and extracellular space-targeted antioxidants

2011

We report here the synthesis of heparin-polynitroxide derivatives (HPNs) in which nitroxide moieties are linked either to uronic acid or glycosamine residues of the heparin macromolecule. HPNs have low anticoagulant activity, possess superoxide scavenging properties, bind to the vascular endothelium/extra-cellular matrix and can be detected by EPR and MRI techniques. As the vascular wall-targeted redox-active paramagnetic compounds, HPNs may have both diagnostic (molecular MRI) and therapeutic (ecSOD mimics) applications.

Nitroxide mediated radical polymerizationmedicine.drug_mechanism_of_actionFactor Xa InhibitorUronic acidAntioxidantslaw.inventionchemistry.chemical_compoundSuperoxideslawDrug DiscoverymedicineExtracellularHumansElectron paramagnetic resonancePharmacologyHeparinSuperoxideOrganic ChemistryElectron Spin Resonance SpectroscopyAnticoagulantsHexosaminesGeneral MedicineHeparinMagnetic Resonance ImagingExtracellular MatrixUronic AcidschemistryBiochemistryMolecular ProbesFactor XaNitrogen OxidesPartial Thromboplastin TimeEndothelium VascularFactor Xa Inhibitorsmedicine.drugMacromoleculeEuropean Journal of Medicinal Chemistry
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Air Pollution Exposure During Pregnancy and Symptoms of Attention Deficit and Hyperactivity Disorder in Children in Europe

2018

Background: Exposure to air pollution during pregnancy may increase attention-deficit/hyperactivity disorder (ADHD) symptoms in children, but findings have been inconsistent. We aimed to study this association in a collaborative study of eight European population-based birth/child cohorts, including 29,127 mother-child pairs. Methods: Air pollution concentrations (nitrogen dioxide [NO2] and particulate matter [PM]) were estimated at the birth address by land-use regression models based on monitoring campaigns performed between 2008 and 2011. We extrapolated concentrations back in time to exact pregnancy periods. Teachers or parents assessed ADHD symptoms at 3-10 years of age. We classified …

Pediatricsmedicine.medical_specialtyEpidemiologyNitrogen DioxideEnvironmental pollution010501 environmental sciences01 natural sciencesOdds03 medical and health sciences0302 clinical medicinePregnancyAir PollutionmedicineHumanslongitudinal studies030212 general & internal medicineChildProspective cohort study0105 earth and related environmental scienceschild developmentparticulate matterInhalation ExposurePregnancybusiness.industryattention deficit disorder with hyperactivityOdds ratiomedicine.diseaseChild developmentConfidence intervalprospective studies3. Good healthEuropemeta-analysisnitrogen oxidesChild PreschoolPrenatal Exposure Delayed EffectsMeta-analysisFemaleenvironmental pollutionAttention Deficit Disorder With Hyperactivity ; Child Development ; Environmental Pollution ; Longitudinal Studies ; Meta-analysis ; Nitrogen Oxides ; Particulate Matter ; Prospective Studiesbusiness
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A model for evaluating the environmental and functional benefits of “innovative” roundabouts

2015

This study looks at the singling out of a multi-parameter criterion for choosing conventional or innovative roundabout layouts, by taking functional, environmental and economic aspects into consideration. The performances of three conventional roundabouts (with different lane number at entries and through the ring), turbo-roundabouts and roundabouts with right-turn bypass lane on all the arms (flower roundabouts) have been compared in terms of vehicle delays and pollutant (carbon dioxide, nitrogen oxides, particle pollution (PM10 and PM2.5)) emissions. By means of closed-form capacity models and with the help of COPERT IV© software, several traffic simulations have been carried out, referre…

PollutantEngineeringSettore ING-IND/11 - Fisica Tecnica AmbientalePollutant emissionsbusiness.industryRoundaboutTransportationenvitonmentTransport engineeringeconomyDemand curveRoundaboutSettore ICAR/04 - Strade Ferrovie Ed AeroportibusinessNitrogen oxidesGeneral Environmental ScienceCivil and Structural EngineeringTransportation Research Part D: Transport and Environment
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A potential solution to avoid overdose of mixed drugs in the event of Covid-19: Nanomedicine at the heart of the Covid-19 pandemic.

2021

Since 2020, the world is facing the first global pandemic of 21st century. Among all the solutions proposed to treat this new strain of coronavirus, named SARS-CoV-2, the vaccine seems a promising way but the delays are too long to be implemented quickly. In the emergency, a dual therapy has shown its effectiveness but has also provoked a set of debates around the dangerousness of a particular molecule, hydroxychloroquine. In particular, the doses to be delivered, according to the studies, were well beyond the acceptable doses to support the treatment without side effects. We propose here to use all the advantages of nanovectorization to address this question of concentration. Using quantum…

Protein Conformation alpha-HelicalComputer science02 engineering and technologyAzithromycinDrug Delivery SystemsPandemicMaterials ChemistryDrug Dosage CalculationsSpectroscopymedia_common0303 health sciencesEvent (computing)021001 nanoscience & nanotechnologyComputer Graphics and Computer-Aided DesignMolecular Docking SimulationNanomedicineRisk analysis (engineering)Spike Glycoprotein CoronavirusDensity functional theory calculationsNanomedicineThermodynamicsNitrogen OxidesAngiotensin-Converting Enzyme 20210 nano-technologyHydroxychloroquineProtein BindingDrugBoron CompoundsCoronavirus disease 2019 (COVID-19)media_common.quotation_subjectSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Molecular Dynamics SimulationAntiviral AgentsArticle03 medical and health sciencesHumansProtein Interaction Domains and MotifsDual therapyPhysical and Theoretical Chemistry030304 developmental biologyDrug transportBinding SitesSARS-CoV-2Molecular dynamics simulationsCOVID-19NanostructuresCOVID-19 Drug TreatmentKineticsQuantum TheoryProtein Conformation beta-StrandNanovectorizationJournal of molecular graphicsmodelling
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Residential Exposure to Outdoor Air Pollution during Pregnancy and Anthropometric Measures at Birth in a Multicenter Cohort in Spain

2011

Background: A growing body of research suggests that prenatal exposure to air pollution may be harmful to fetal development. We assessed the association between exposure to air pollution during pregnancy and anthropometric measures at birth in four areas within the Spanish Children’s Health and Environment (INMA) mother and child cohort study. Methods: Exposure to ambient nitrogen dioxide (NO2) and benzene was estimated for the residence of each woman (n = 2,337) for each trimester and for the entire pregnancy. Outcomes included birth weight, length, and head circumference. The association between residential outdoor air pollution exposure and birth outcomes was assessed with linear regress…

Questionnaires:Health Care::Environment and Public Health::Public Health::Environmental Pollution::Environmental Exposure::Environmental Monitoring [Medical Subject Headings]Fetus -- CreixementPediatricsHealth Toxicology and MutagenesisEspañaair pollution:Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Size::Body Weight [Medical Subject Headings]:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]Cohort StudiesbenzenebirthRecién NacidoPregnancyResidence CharacteristicsSurveys and Questionnaires:Chemicals and Drugs::Chemical Actions and Uses::Toxic Actions::Environmental Pollutants::Air Pollutants [Medical Subject Headings]:Health Care::Environment and Public Health::Public Health::Environmental Pollution::Environmental Exposure::Maternal Exposure [Medical Subject Headings]Birth WeightBody SizeMedicineProspective StudiesProspective cohort studyTamaño Corporal:Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction::Pregnancy [Medical Subject Headings]:Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Data Collection::Questionnaires [Medical Subject Headings]Vehicle Emissions:Geographicals::Geographic Locations::Europe::Spain [Medical Subject Headings]Dióxido de NitrógenoPeso al NacerAir PollutantsInhalation ExposureanthropometryAdultoDistribución Espacial de la Población:Chemicals and Drugs::Complex Mixtures::Vehicle Emissions [Medical Subject Headings]Adulto JovenEstudios ProspectivosAire -- Contaminació -- Efectes fisiològics -- EpidemiologiaExposición MaternaHumanos:Health Care::Environment and Public Health::Public Health::Environmental Pollution::Environmental Exposure::Inhalation Exposure [Medical Subject Headings]Maternal ExposureFemeninaInfant Small for Gestational AgeCohort:Named Groups::Persons::Age Groups::Infant::Infant Newborn::Infant Low Birth Weight::Infant Small for Gestational Age [Medical Subject Headings]:Chemicals and Drugs::Inorganic Chemicals::Nitrogen Compounds::Nitrogen Oxides [Medical Subject Headings]Emisiones de VehículosFemalepregnancyEnvironmental MonitoringCohort studyAdultmedicine.medical_specialty:Named Groups::Persons::Age Groups::Adult::Young Adult [Medical Subject Headings]nitrogen dioxideEmbarazoBirth weightMonitoreo del AmbienteExposición por Inhalación:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Body Constitution::Body Weights and Measures::Body Size [Medical Subject Headings]:Named Groups::Persons::Age Groups::Infant::Infant Newborn [Medical Subject Headings]Young AdultRecién Nacido Pequeño para la Edad Gestacional:Named Groups::Persons::Age Groups::Adult [Medical Subject Headings]HumansPregnancybusiness.industryResearchBencenoInfant NewbornPublic Health Environmental and Occupational Healthbirth weightAnthropometrymedicine.disease:Health Care::Environment and Public Health::Public Health::Epidemiologic Measurements::Demography::Residence Characteristics [Medical Subject Headings]Confidence interval:Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons Cyclic::Hydrocarbons Aromatic::Benzene [Medical Subject Headings]:Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Prospective Studies [Medical Subject Headings]:Check Tags::Female [Medical Subject Headings]Spain:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies [Medical Subject Headings]Contaminantes del AireSmall for gestational ageEstudios de CohortesbusinessDemographyEnvironmental Health Perspectives
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The organic air pollutant cumene hydroperoxide interferes with NOantioxidant role in rehydrating lichen

2013

Organic pollutants effects on lichens have not been addressed. Rehydration is critical for lichens, a burst of free radicals involving NO occurs. Repeated dehydrations with organic pollutants could increase oxidative damage. Our aim is to learn the effects of cumene hydroperoxide (CP) during lichen rehydration using Ramalina farinacea (L.) Ach., its photobiont Trebouxia spp. and Asterochloris erici. Confocal imaging shows intracellular ROS and NO production within myco and phycobionts, being the chloroplast the main source of free radicals. CP increases ROS, NO and lipid peroxidation and reduces chlorophyll autofluorescence, although photosynthesis remains unaffected. Concomitant NO inhibit…

TrebouxiaChlorophyllAntioxidantLichensHealth Toxicology and Mutagenesismedicine.medical_treatmentBOTANICAToxicologymedicine.disease_causePhotosynthesisRamalina farinaceaLipid peroxidationchemistry.chemical_compoundBotanymedicineBenzene DerivativesDesiccationPhotosynthesisVolatile organic pollutantsBIOLOGIA VEGETALAir PollutantsbiologyDehydrationROSNitric oxideGeneral Medicinebiology.organism_classificationPollutionOxidative StressBiochemistrychemistryCumene hydroperoxideChlorophyllTrebouxiaNitrogen OxidesOxidation-ReductionOxidative stress
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Heparin–polynitroxide derivatives: a platform for new diagnostic and therapeutic agents in cardiovascular disease?

2013

Vascular wall extracellular oxidative stress Cardiovascular disease (CVD; mainly atherosclerosis, hypertension and diabetes mellitus) remains a major cause of death in western society [1]. Despite substantial progress achieved, the diagnosis of CVD often comes too late, when the disease has already advanced to therapeutically incurable stages. The development of efficient diagnostic probes allowing early non-invasive diagnostics, as well as drugs which can prevent or reverse CVD and/or its complications (e.g., myocardium infarctus and stroke) are highly desired tasks of the modern cardiovascular medicinal chemistry.

Vascular wallmedicine.medical_specialtyPathologyDiseasemedicine.disease_causeCardiovascular SystemDiabetes mellitusDrug DiscoverymedicineAnimalsHumanscardiovascular diseasesIntensive care medicineStrokeCause of deathPharmacologyHeparinbusiness.industryAnticoagulantsHeparinmedicine.diseaseMr imagingOxidative StressCardiovascular DiseasesMolecular MedicineNitrogen OxidesbusinessOxidative stressmedicine.drugFuture Medicinal Chemistry
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NO formation tendency characterization for solid fuels in fluidized beds

2013

Abstract Usually the standard fuel analysis is not enough to allow for accurate NO emission predictions in large scale fluidized bed combustion. This paper presents NO formation tendency characterization results from novel laboratory measurements in a small-scale fluidized bed combustor. With the special two-stage oxidation method it is possible to eliminate the observed problems of unstable test conditions during rapid pyrolysis of high-volatile fuels in batch combustion. Experimental results of the conversion of fuel nitrogen to NO are presented for wide range of fuels, ranging from coal-type fuels to peat, biomasses and wastes. A NO formation tendency database is formed based on the resu…

Waste managementbusiness.industryGeneral Chemical EngineeringOrganic ChemistryEnergy Engineering and Power TechnologyCombustionSolid fuelFuel mass fractionnitrogen oxidesFuel Technologyfluidized bed combustionFluidized bedEnvironmental scienceCoalcharacterizationFluidized bed combustionCharbusinessta116Chemical looping combustionsolid fuelfuel nitrogenFuel
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