6533b824fe1ef96bd128024e
RESEARCH PRODUCT
Heparin–polynitroxide derivatives: a platform for new diagnostic and therapeutic agents in cardiovascular disease?
Vasily D. SenAndrei L. Kleschyovsubject
Vascular wallmedicine.medical_specialtyPathologyDiseasemedicine.disease_causeCardiovascular SystemDiabetes mellitusDrug DiscoverymedicineAnimalsHumanscardiovascular diseasesIntensive care medicineStrokeCause of deathPharmacologyHeparinbusiness.industryAnticoagulantsHeparinmedicine.diseaseMr imagingOxidative StressCardiovascular DiseasesMolecular MedicineNitrogen OxidesbusinessOxidative stressmedicine.drugdescription
Vascular wall extracellular oxidative stress Cardiovascular disease (CVD; mainly atherosclerosis, hypertension and diabetes mellitus) remains a major cause of death in western society [1]. Despite substantial progress achieved, the diagnosis of CVD often comes too late, when the disease has already advanced to therapeutically incurable stages. The development of efficient diagnostic probes allowing early non-invasive diagnostics, as well as drugs which can prevent or reverse CVD and/or its complications (e.g., myocardium infarctus and stroke) are highly desired tasks of the modern cardiovascular medicinal chemistry.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-03-01 | Future Medicinal Chemistry |