Search results for "Node"

Oral lesions and immune status of HIV infected adults from eastern Nepal

2013

Objective: To document the prevalence, age and gender distribution of oral lesions in HIV infected adults and the influence of highly active antiretroviral therapy and correlate them to the immune status of the patients. Materials and Methods: Oral lesions were diagnosed by a detailed physical examination by trained and calibrated examiners according to the case definitions established by the Oral HIV/AIDS research alliance. Demographic details, risk behavior patterns and oral symptoms and habits were collected by a questionnaire. Results: 81 patients; 54 men and 27 women aged between 20 ' 55 years participated in the study. A total of 49 patients; 60.5% had some oral lesion when examined. …

Recent advances on HIV DNA vaccines development: Stepwise improvements to clinical trials.

2019

According to WHO (World Health Organization) reports, more than 770,000 people died from HIV and almost 1.7 million people becoming newly infected in the worldwide in 2018. Therefore, many attempts should be done to produce a forceful vaccine to control the AIDS. DNA-based vaccines have been investigated for HIV vaccination by researches during the recent 20 years. The DNA vaccines are novel approach for induction of both type of immune responses (cellular and humoral) in the host cells and have many advantages including high stability, fast and easy of fabrication and absence of severe side effects when compared with other vaccination methods. Recent studies have been focused on vaccine de…

Phosphoproteinphosphatase activity in sea urchin embryos

1964

Si e studiata l'attivita fosfoproteinfosfatasica in omogenati totali di uova ed embrioni diParacentrotus lividus e diArbacia lixula. La reazione ha un optimum a pH acido, e stimolata da K+ e Na+ ed e inibita da Ca++ e Mg++. L'attivita enzimatica aumenta tra la fecondazione e lo stadio a 64 blastomeri; in seguito rimane costante fino a blastula con mesenchima; quindi generalmente decresce.

Ganodermycin, a novel inhibitor of CXCL10 expression from Ganoderma applanatum

2011

CXCL10 (inducible protein-10) is a highly inducible chemoattractant, which contributes to the recruitment of inflammatory cells, such as macrophages and T-lymphocytes, and thereby has important roles in chronic inflammatory conditions. In a search for new inhibitors of CXCL10 expression in MonoMac6 cells, a novel compound, designated as Ganodermycin, was isolated from fermentations of the basidiomycete Ganoderma applanatum. The structure was determined by a combination of spectroscopic techniques. Ganodermycin inhibited the lipopolysaccharide (LPS)/interferon (IFN)-γ-induced CXCL10 promoter activity in transiently transfected MonoMac6 cells in a dose-dependent manner with IC(50) values of 1…

Some observations on the metabolism of S35-methionine during development of the sea urchin eggs

1958

Si e studiato il metabolismo della metionina-S35 nella frazione non-proteica (TCA-solubile) nel corso dello sviluppo diParacentrotus lividus.

Incorporation of S35-Methionine in the microsomes and soluble proteins during the early development of the sea urchin egg

1960

Nelle uova diParacentrotus lividus gia pochi minuti dopo la fecondazione si inizia una attiva incorporazione di metionina-S35 nei microsomi e nelle proteine solubili. Si avanza l'ipotesi che cio possa indicare l'iniziarsi molto precoce della sintesi di una o piu proteine.

Pyrrolo[1,2-f]phenanthridines and related non-rigid analogues as antiviral agents.

2002

Abstract The pyrrolo[1,2- f ]phenanthridines 8 – 22 and the corresponding non-rigid analogues 23 – 41 were synthesised and their ability to inhibit the replication of HIV-1 was tested. Only the polycyclic derivatives 10 , 11 , and 13 showed a weak anti -HIV activity, whereas several pyrrolo-phenanthridines ( 8 , 10 , 16 – 18 ) were found to stimulate the multiplication of MT-4 cells at low concentrations. Derivative 10 demonstrated to possess the unique property of stimulating the multiplication of lymphocytes joined to HIV inhibition.

Control of HIV-infection with Visits Scheduled Every Four or Every Six Months. A Comparative Randomized Study

2011

A model for the cortical reaction of fertilization in the sea-urchin egg.

1953

Da una soluzione di lipovitellina (la lipoproteina del tuorlo dell'uovo di pollo) trattata con spermi vivi diArbacia lixula si ha liberazione di fosfolipidi. Questo esperimento e considerato un modello della reazione corticale di fecondazione dell'uovo di riccio di mare.

Modelling phase transition kinetics of chenodeoxycholic acid with the Runge–Kutta method

2009

Abstract The phase transition kinetics of two chenodeoxycholic acid polymorphic modifications— form I (stable at high temperature), form III (stable at low temperature) and the amorphous phase has been examined under various conditions of temperature and relative humidity. Form III conversion to form I was examined at high temperature conditions and was found to be non-spontaneous, requiring seed crystals for initiation. The formation kinetic model of form I was created incorporating the three-dimensional seed crystal growth, the phase transition rate proportion to the surface area of form I crystals, and the influence of the amorphous phase surface area changes with an empirical stage poin…