Search results for "Node"
showing 10 items of 1701 documents
Pharmacological Properties and use of Ganoderma Lucidum in modern medicine
2023
Currently, lignicolous fungi, commonly referred to as polypores, belonging to the division of Basidiomycota (basidiomycetes), are of great interest. Ganoderma lucidum is one of the representatives. They grow and develop in the wood of trees and shrubs, both living and dead ones. These fungi belong to the world’s most valued and sought-after medicinal plants, used as dietary supplements and applied in medicine. Fungal extracts can be used both for the purposes of prevention and treatment of the acute and chronic diseases. Clinical studies have confirmed the unique characteristics of parasitic medicinal fungi: wide possibilities of application, a high supportive and enhancing role taking into…
Electrochemical oxidation of tetramethoxy precursor as a key step for the synthesis of coenzyme Q10
2007
The feasibility of electrosynthesis of coenzyme Q10 (1) by electrooxidation of tetramethoxy precursor (2) has been investigated at carbon, Pt and BDD anodes in a divided cell. The process strongly depends on the applied potential, anode material and water content of the solvent. At carbon anodes in CH3CN/CH2Cl2 + 0.15 M Bu4NBF4 at proper operative conditions high faradic efficiency (>60%) and excellent selectivity (95–97%) of the target product were obtained. Keywords: Electrosynthesis, Coenzyme Q10, Anodic oxidation
Cholesterol Dependence of Collagen and Echovirus 1 Trafficking along the Novel α2β1 Integrin Internalization Pathway
2013
We have previously shown that soluble collagen and a human pathogen, echovirus 1 (EV1) cluster α2β1 integrin on the plasma membrane and cause their internalization into cytoplasmic endosomes. Here we show that cholesterol plays a major role not only in the uptake of α2β1 integrin and its ligands but also in the formation of α2 integrin-specific multivesicular bodies (α2-MVBs) and virus infection. EV1 infection and α2β1 integrin internalization were totally halted by low amounts of the cholesterol-aggregating drugs filipin or nystatin. Inhibition of cholesterol synthesis and accumulation of lanosterol after ketoconazole treatment inhibited uptake of collagen, virus and clustered integrin, an…
Preclinical immunomodulation by the probiotic Bifidobacterium breve M-16V in early life
2016
This study aimed to investigate the effect of supplementation with the probiotic Bifidobacterium breve M-16V on the maturation of the intestinal and circulating immune system during suckling. In order to achieve this purpose, neonatal Lewis rats were supplemented with the probiotic strain from the 6th to the 18th day of life. The animals were weighed during the study, and faecal samples were obtained and evaluated daily. On day 19, rats were euthanized and intestinal wash samples, mesenteric lymph node (MLN) cells, splenocytes and intraepithelial lymphocytes (IEL) were obtained. The probiotic supplementation in early life did not modify the growth curve and did not enhance the systemic immu…
Increased gene expression of a cytokine-related molecule and profilin after activation of Suberites domuncula cells with xenogeneic sponge molecule(s)
2000
Porifera (sponges) constitute the lowest metazoan phylum, Experiments examined whether sponges can recognize self/nonself molecules. Cells from the marine sponge Suberites domuncula were incubated with membranes from either S. domuncula or another marine sponge, Geodia cydonium, as well as with recombinant alpha-integrin from G. cydonium. The cells responded immediately with a rise of intracellular Ca2+ ([Ca-i(2+)]) if they were treated with membranes from G. cydonium but not after treatment by those from S. domuncula. This change of [Ca-i(2+)] was also recorded with G. cydonium alpha-integrin. In parallel, the expression of two genes was strongly upregulated; one codes for a cytokine-relat…
An advanced and distributed control architecture based on intelligent agents and neural networks
2004
A new layered architecture for the implementation of intelligent distributed control systems is proposed. The proposed architecture distinguishes four layers in a distributed control system. Upper layer consists of a digital control layer, where high level decisions are taken. This level is implemented by means of intelligent agents that carry out the discrete control functions, system supervision as well as diagnosis and fault tolerance. Third layer deals with numeric values, performs analog operations and implement analog control loops. It is also in carry of the conversion from numerical variables values to evaluated expressions. This layer has been implemented by means of neural network…
2020
The growth of cloud-based services is mainly supported by the core networking infrastructures of large-scale data centers, while the scalability of these services is influenced by the performance and dependability characteristics of data centers. Hence, the data center network must be agile and reconfigurable in order to respond quickly to the ever-changing application demands and service requirements. The network must also be able to interconnect the big number of nodes, and provide an efficient and fault-tolerant routing service to upper-layer applications. In response to these challenges, the research community began exploring novel interconnect topologies, namely: Flecube, DCell, Ficonn…
Cytokine production pathway in the elderly.
1996
It is well known that aging is associated with various alterations in lymphoid cell functions, particularly with a progressive decline in immune responsiveness to exogenous antigens and increasing incidence of autoimmune phenomena. Many studies have been focused on the mechanisms of the immunologic features of aging. this review describes our results of studies performed to determine the influence of age on the capacity to produce interleukin-2 (IL-2), interferon-gamma (IFN-gamma), interleukin-4 (IL-4), interleukin-t (IL-5), interleukin-6 (IL-6) and tumor necrosis factor (TNF). Mitogen-stimulated cultures of mononuclear cells (MNC) from human beings were assessed for cytokine-producing capa…
Interleukin 4 suppresses primary interferon gamma response by T cells immunized in vivo and cultured in vitro with interleukin 2.
1996
This paper describes a novel primary in vivo/in vitro culture system which allows analysis of the effect of IL-4 added to culture 1 day after immunization on the production of IFN-gamma. Mice are immunized epicutaneously with picryl chloride (TNP) and draining lymph node cells were harvested 1 day later. These cells (1 day lymph node cells), when cultured in vitro for 3 days in the presence of IL-2, either continuously or as a pulse, give an IFN-gamma response on reexposure to antigen 3 days later. This production of IFN-gamma is both antigen-specific and genetically (MHC)-restricted and is due to both CD8+ and CD4+ T cells. However, if 1 day lymph node cells are cultured with both IL-2 and…