Search results for "Norepinephrine"

Die Beziehung zwischen der Guanethidin-Konzentration im Rattenherzen und dem Noradrenalingehalt

1962

Guanethidine was intravenously injected into rats and was subsequently determined in the hearts by extracting the tissue with trichloroacetic acid, purifying the extracts on cation exchange columns and by paper chromatography, and coupling the guanethidine with ninhydrin in alkaline solution before fluorimetric estimation. The concentration in the heart reached a maximum of 9 μg/g within 15 min of injecting 15 mg/kg, and was still 6.2 and 5.7 μg/g after 1 and 3 hours, respectively. Guanethidine caused a decrease of the heart noradrenaline concentration, measured fluorimetrically, by 56% in 3 hours and by 93% in 14 hours. The adrenaline concentration was likewise decreased. A metabolite with…

Die Wirkung von Harmalin auf die Konzentration von Noradrenalin und Adrenalin im Herzen

1959

A single injection of harmaline increases the noradrenaline and adrenaline concentration in the rat heart. The maximum effect is obtained after about 40 min.

DMPP and the adrenergic nerve terminal: mechanisms of noradrenaline release from vesicular and extravesicular compartments.

1977

DMPP (1,1-dimethyl-4-phenylpiperazine) in various concentrations between 1.6×10−6 M and 6.2×10−5 M was infused into isolated rabbit hearts to study the neuronal release and uptake of noradrenaline.

Die Wirkung von Pharmaka auf die Elimination von Noradrenalin aus der Perfusionsfl�ssigkeit und die Noradrenalinaufnahme in das isolierte Herz

1964

Die Noradrenalin-Abgabe aus dem isolierten Kaninchenherzen bei sympathischer Nervenreizung und ihre pharmakologische Beeinflussung

1962

Effects on Arterial Blood Pressure of the Methanol and Dichloromethanol Extracts from Schinus molle L. in Rats

1996

The effects on arterial blood pressure of the methanol and dichloromethanol extracts from Schinus molle L. were analysed in urethane anaesthetized rats. In normotensive rats, the mean arterial blood pressure was significantly reduced by the i.v. administration of both extracts. The dichloromethanol extract inhibited the effects of noradrenaline on arterial blood pressure in the anaesthetized rat and it reduced the maximal contractile effect (Emax) induced by noradrenaline on rat vas deferens in the organ bath. However, the methanol extract did not modify the effects of noradrenaline in the evaluated tests.

Noradrenalin- und Adrenalingehalt des Rattenherzens bei experimenteller Niereninsuffizienz

1960

Cardiovascular effects of the methanol and dichloromethanol extracts fromTeucrium cartaginenses L.

1998

Methanol and dichloromethanol extracts of the leaves and stems of Teucrium cartaginensesL. have been tested for their effects on resting arterial blood pressure, heart rate and noradrenaline induced hypertension. Both extracts administered i.v. to urethane anaesthetized normotensive rats reduced mean arterial blood pressure and heart valve, while only the dichloromethanol extract prevented noradrenaline induced hypertension. © 1998 John Wiley & Sons, Ltd.

In vivo investigations on microcirculatory disturbances induced by crenated erythrocytes following norepinephrine application

1974

Using a special apparatus for high resolution cinephotomicrography, which allows simultaneous observation and recording of microcirculatory changes, alterations in blood flow patterns and in red cell shape during norepinephrine acting have been studied. Under physiological conditions, and during slowing of capillary blood flow due to gradual removing of 20–25% of the circulating blood volume, the normal red cells are extremely deformable while passing through mesenteric capillaries. After application of norepinephrine a general arteriolar constrictive response in the bowel wall occurs, causing a further slowing of the capillary blood flow in the mesentery. Under these circumstances the eryt…

Activation of alpha-1A adrenoceptors mobilizes calcium from the intracellular stores in myocytes from rat portal vein.

1994

International audience; Intracellular free Ca++ concentration ([Ca++]i) was monitored using the fluorescence from the dye fura-2-acetoxymethylester in single myocytes from rat portal vein. In the presence of oxodipine (a L-type Ca++ channel inhibitor), norepinephrine (10 microM) evoked transient increases in [Ca++]i which were related to release of Ca++ from intracellular stores. The alpha-1 adrenoceptors mediating intracellular Ca++ release and inositol phosphate accumulation were identified by using subtype-selective agonists and antagonists. Pretreatment with chloroethylclonidine had little effect on the norepinephrine-induced increase in [Ca++]i and inositol phosphate accumulation. In c…