Search results for "Normal"
showing 10 items of 2571 documents
Response Assessment to Cancer Therapy
2021
Cancer generically refers to a group of diseases showing an uncontrolled division of abnormal cells potentially having the ability to invade, through the blood and lymph systems, nearby tissues or spread to other parts of the body.
Cost-effectiveness analysis of the first-line EGFR-TKIs in patients with advanced EGFR-mutated non-small-cell lung cancer.
2021
To evaluate the cost-effectiveness of first-line treatments, such as erlotinib, gefitinib, afatinib, dacomitinib, and osimertinib, for patients diagnosed with stage IIIB/IV NSCLC harboring EGFR mutations.A partitioned survival model was developed to estimate quality-adjusted life-year (QALY) and incremental cost-effectiveness ratio (ICER) from the perspective of the Spanish National Health System. Two Bayesian NMAs were performed independently, by using the polynomial fraction method to fit Kaplan-Meier curves for overall survival and progression-free survival. Deterministic and probabilistic sensitivity analyses were performed to evaluate the uncertainty.The ICER was calculated for the fou…
Triple Negative Myelofibrosis and Myelodysplastic Syndrome with Fibrosis: Clinico-Biological Characterization and Correlation with Gene Mutations
2018
Abstract Introduction: Triple negative primary myelofibrosis (TN-PMF) and myelodysplastic syndromes with fibrosis (F-MDS) are rare entities, often difficult to distinguish each other. Currently, no specific molecular markers allowing a precise differential diagnosis are available. In this sense, next generation techniques (NGS) might be useful to distinguish between both entities and to refine prognosis. Methods: Thirty-nine patients with TN-PMF (n=16) or F-MDS (n=23) were analyzed, Targeted NGS was performed in 28 cases (10 TN-PMF and 18 F-MDS) using the Sophia Genetics Myeloid Tumor Solution Panel including the following genes: ABL1, ASXL1, BRAF, CALR, CBL,CEBPA, CSF3R,CSNK1A1,DNMT3A, ETV…
Evaluation of atezolizumab immunogenicity: Efficacy and safety (Part 2).
2022
Abstract Antibody therapeutics can be associated with unwanted immune responses resulting in the development of anti‐drug antibodies (ADA). Optimal methods to evaluate the potential effects of ADA on clinical outcomes in oncology are not well established. In this study, we assessed efficacy and safety, based on ADA status, in patients from over 10 clinical trials that evaluated the immune checkpoint inhibitor atezolizumab as a single agent or as combination therapy for several types of advanced cancers. ADA can only be observed post randomization, and imbalances in baseline prognostic factors can confound the interpretation of ADA impact. We applied methodology to account for the confoundin…
Polarization modulation instability in a Manakov fiber system
2015
International audience; The Manakov model is the simplest multicomponent model of nonlinear wave theory: It describes elementary stable soliton propagation and multisoliton solutions, and it applies to nonlinear optics, hydrodynamics, and Bose-Einstein condensates. It is also of fundamental interest as an asymptotic model in the context of the widely used wavelength-division-multiplexed optical fiber transmission systems. However, although its physical relevance was confirmed by the experimental observation of Manakov (vector) solitons in a planar waveguide in 1996, there have in fact been no quantitative experiments confirming its validity for nonlinear dynamics other than soliton formatio…
Intraspecific Differences in Spectral Reflectance Curves as Indicators of Reduced Vitality in High-Arctic Plants
2017
Remote sensing is a suitable candidate for monitoring rapid changes in Polar regions, offering high-resolution spectral, spatial and radiometric data. This paper focuses on the spectral properties of dominant plant species acquired during the first week of August 2015. Twenty-eight plots were selected, which could easily be identified in the field as well as on RapidEye satellite imagery. Spectral measurements of individual species were acquired, and heavy metal contamination stress factors were measured contemporaneously. As a result, a unique spectral library of dominant plant species, heavy metal concentrations and damage ratios were achieved with an indication that species-specific chan…
Scene-based spectral calibration assessment of high spectral resolution imaging spectrometers
2009
An accurate knowledge of the spectral calibration of imaging spectrometers is required for optimum data processing and interpretation. The scene-based spectral characterization of imaging spectrometers is frequently necessary to update or replace the pre-flight laboratory-based spectral characterization supplied by the data provider. An automatic method for the estimation of spectral calibration parameters (channel position and bandwidth) at atmospheric absorption regions from high spectral resolution imaging spectrometers (spectral sampling interval below 5 nm) is presented in this contribution. The method has been tested on two commercial instruments with spectral sampling intervals below…
Oral, facial, digital, vertebral anomalies with psychomotor delay: a mild form of OFD type Gabrielli?
2002
A girl with oral, facial, and digital anomalies presented at birth with a large cleft palate filled by a nasopharyngeal mass and was found later to have several vertebral anomalies and mental retardation. A similar phenotype has been previously reported in a sporadic male patient [Gabrielli et al., 1994: Am J Med Genet 53:290-293], suggesting a new variant form of oral-facial-digital syndrome.
Foucault and deaf education in Finland
2016
The influence of Michel Foucault’s thinking in critical disability studies, and to social studies of deafness, can hardly be doubted. Foucault has offered valuable tools for the critical rethinking of deaf education and pedagogy with respect to normalization and disciplinary power, which are integrally related to the historical construction of deafness as deficiency and pathology by modern, medical, and psychological knowledge. This article explores the applicability and critical potential of the Foucauldian concepts of disciplinary power, surveillance, and normalization within the specific context of the history of deaf education in Finland. The article focuses on the modernization of the …
On the Convergence of Formal Integrals in Finite Time
1982
Consider a differential system: x = f (x) + e g(x), \(x \in {R^n}.\). Let h(x) = ho(x) + eh1 (x)... a “third” integral. For finite time t, I obtain an eo such that the series h(x) converges if e > eo. When t tends to infinite, eo tends to zero.